Chlorpheniramine Dihydrocodeine Pseudoephedrine

Chlorpheniramine Dihydrocodeine Pseudoephedrine Brand Names

ColdCough | DiHydro CP | Hydro-Tussin DHC | Pancof | Uni-Cof

What is Chlorpheniramine Dihydrocodeine Pseudoephedrine

NOTE: These products are discontinued in the U.S.

Chlorpheniramine dihydrocodeine pseudoephedrine are used together in an oral preparation to relieve cough, congestion, and other symptoms due to colds, acute respiratory infections, acute and chronic bronchitis, and allergies.

Chlorpheniramine is an antihistamine agent similar to diphenhydramine, but is less sedating.

Dihydrocodeine is an opiate antitussive used for cough suppression. It is structurally related to codeine, however, its antitussive and sedative properties are greater than codeine.

Pseudoephedrine is a sympathomimetic agent that relieves nasal and sinus congestion.

Chlorpheniramine dihydrocodeine pseudoephedrine formulations are available by prescription-only for adults and pediatric patients 6 years of age and older.

Indications

1. allergic rhinitis
2. bronchitis
3. common cold
4. cough
5. nasal congestion

For the temporary relief of cough and nasal congestion associated with upper respiratory tract infections (i.e., bronchitis, common cold) and allergies (i.e., allergic rhinitis)

Side Effects

1. abdominal pain
2. agranulocytosis
3. anaphylactoid reactions
4. angina
5. anorexia
6. anxiety
7. aplastic anemia
8. arrhythmia exacerbation
9. ataxia
10. blurred vision
11. colitis
12. confusion
13. constipation
14. contact dermatitis
15. diaphoresis
16. diarrhea
17. dizziness
18. drowsiness
19. dyspepsia
20. dysuria
21. erythema
22. fatigue
23. flushing
24. hallucinations
25. headache
26. impaired cognition
27. insomnia
28. interstitial nephritis
29. irritability
30. miosis
31. myocardial infarction
32. nausea
33. ocular hypertension
34. orthostatic hypotension
35. palpitations
36. photophobia
37. physiological dependence
38. premature ventricular contractions (PVCs)
39. pruritus
40. psychological dependence
41. psychosis
42. rash
43. renal failure (unspecified)
44. respiratory depression
45. restlessness
46. rhabdomyolysis
47. seizures
48. sinus tachycardia
49. stroke
50. supraventricular tachycardia (SVT)
51. thrombocytopenia
52. urinary retention
53. vomiting
54. weakness
55. xerophthalmia
56. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• angina
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• diarrhea
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• head trauma
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intracranial pressure
• infants
• labor
• MAOI therapy
• neonates
• opiate agonist hypersensitivity
• peptic ulcer disease
• pregnancy
• prostatic hypertrophy
• renal impairment
• respiratory depression
• respiratory infection
• respiratory insufficiency
• sleep apnea
• substance abuse
• tachycardia
• tobacco smoking
• ulcerative colitis
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
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• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
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• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
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• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Trimipramine
• Triprolidine
• Trospium
• Tucatinib
• Umeclidinium; Vilanterol
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vasodilators
• Vasopressors
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Yohimbine
• Zafirlukast
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem