Chlorpheniramine Dihydrocodeine Pseudoephedrine Brand Names
ColdCough | DiHydro CP | Hydro-Tussin DHC | Pancof | Uni-Cof
What is Chlorpheniramine Dihydrocodeine Pseudoephedrine
NOTE: These products are discontinued in the U.S.
Chlorpheniramine dihydrocodeine pseudoephedrine are used together in an oral preparation to relieve cough, congestion, and other symptoms due to colds, acute respiratory infections, acute and chronic bronchitis, and allergies.
Chlorpheniramine is an antihistamine agent similar to diphenhydramine, but is less sedating.
Dihydrocodeine is an opiate antitussive used for cough suppression. It is structurally related to codeine, however, its antitussive and sedative properties are greater than codeine.
Pseudoephedrine is a sympathomimetic agent that relieves nasal and sinus congestion.
Chlorpheniramine dihydrocodeine pseudoephedrine formulations are available by prescription-only for adults and pediatric patients 6 years of age and older.
Indications
- allergic rhinitis
- bronchitis
- common cold
- cough
- nasal congestion
For the temporary relief of cough and nasal congestion associated with upper respiratory tract infections (i.e., bronchitis, common cold) and allergies (i.e., allergic rhinitis)
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angina
- anorexia
- anxiety
- aplastic anemia
- arrhythmia exacerbation
- ataxia
- blurred vision
- colitis
- confusion
- constipation
- contact dermatitis
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dysuria
- erythema
- fatigue
- flushing
- hallucinations
- headache
- impaired cognition
- insomnia
- interstitial nephritis
- irritability
- miosis
- myocardial infarction
- nausea
- ocular hypertension
- orthostatic hypotension
- palpitations
- photophobia
- physiological dependence
- premature ventricular contractions (PVCs)
- pruritus
- psychological dependence
- psychosis
- rash
- renal failure (unspecified)
- respiratory depression
- restlessness
- rhabdomyolysis
- seizures
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- thrombocytopenia
- urinary retention
- vomiting
- weakness
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- angina
- asthma
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- contact lenses
- coronary artery disease
- diabetes mellitus
- diarrhea
- driving or operating machinery
- emphysema
- geriatric
- GI obstruction
- head trauma
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intracranial pressure
- infants
- labor
- MAOI therapy
- neonates
- opiate agonist hypersensitivity
- peptic ulcer disease
- pregnancy
- prostatic hypertrophy
- renal impairment
- respiratory depression
- respiratory infection
- respiratory insufficiency
- sleep apnea
- substance abuse
- tachycardia
- tobacco smoking
- ulcerative colitis
- urinary retention
Interactions
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
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- Triprolidine
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vasodilators
- Vasopressors
- Vemurafenib
- Venlafaxine
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Vortioxetine
- Yohimbine
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
