Brompheniramine Hydrocodone Pseudoephedrine

Brompheniramine Hydrocodone Pseudoephedrine Brand Names

Anaplex HD | Bromcomp HC | Bromphenex HD | Bromplex HD | BroveX HC | Drocon CS | EndaCof-HC | M-End | SymTan A

What is Brompheniramine Hydrocodone Pseudoephedrine

NOTE: These products are discontinued in the U.S.

Brompheniramine hydrocodone pseudoephedrine are used together in an oral preparation to relieve cough and congestion and to facilitate bronchial and sinus drainage.

This combination is indicated for the relief of nasal congestion and dry, non-productive cough associated with the common cold, influenza, sinusitis, or bronchitis.

Brompheniramine is a first-generation sedating antihistamine (H1-blocker) of the propylamine class that dries nasal and sinus passages. Hydrocodone, similar to codeine, is an opiate antitussive used for cough suppression.

The antitussive and sedative properties of hydrocodone are greater than codeine. Hydrocodone also has analgesic properties, although it is not used for this purpose when combined with brompheniramine and pseudoephedrine.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle.

This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency leading to decreased congestion.

Indications

  1. common cold
  2. cough
  3. eustachian tube congestion
  4. nasal congestion

For the relief of cough and upper respiratory congestion (nasal congestion and eustachian tube congestion) due to the common cold and acute respiratory infections (e.g., influenza, sinusitis, and bronchitis)

Side Effects

  1. abdominal pain
  2. angina
  3. anorexia
  4. anxiety
  5. arrhythmia exacerbation
  6. blurred vision
  7. confusion
  8. constipation
  9. delirium
  10. diarrhea
  11. diplopia
  12. dizziness
  13. drowsiness
  14. dyskinesia
  15. dyspepsia
  16. dysphoria
  17. dysuria
  18. emotional lability
  19. euphoria
  20. excitability
  21. headache
  22. hypertension
  23. hypotension
  24. impaired cognition
  25. impotence (erectile dysfunction)
  26. insomnia
  27. irritability
  28. lethargy
  29. mydriasis
  30. myocardial infarction
  31. nausea
  32. palpitations
  33. photophobia
  34. premature ventricular contractions (PVCs)
  35. pruritus
  36. psychological dependence
  37. rash
  38. respiratory depression
  39. restlessness
  40. seizures
  41. sinus tachycardia
  42. stroke
  43. supraventricular tachycardia (SVT)
  44. tinnitus
  45. tolerance
  46. tremor
  47. urinary retention
  48. urticaria
  49. vertigo
  50. visual impairment
  51. vomiting
  52. weakness
  53. withdrawal
  54. xerophthalmia
  55. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • acute abdomen
  • acute myocardial infarction
  • angina
  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • diarrhea
  • driving or operating machinery
  • emphysema
  • geriatric
  • GI obstruction
  • head trauma
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • labor
  • MAOI therapy
  • neonates
  • opiate agonist hypersensitivity
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • seizure disorder
  • status asthmaticus
  • substance abuse
  • tachycardia
  • tobacco smoking
  • ulcerative colitis
  • urinary retention

Interactions

  • Abiraterone
  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
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  • Acetaminophen; Dichloralphenazone; Isometheptene
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  • Chlorpheniramine; Hydrocodone; Phenylephrine
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  • Chlorpromazine
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  • Polyethylene Glycol; Electrolytes
  • Polyethylene Glycol; Electrolytes; Ascorbic Acid
  • Polyethylene Glycol; Electrolytes; Bisacodyl
  • Posaconazole
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prasugrel
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procaine
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propofol
  • Propoxyphene
  • Propranolol
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Riociguat
  • Risperidone
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rizatriptan
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Safinamide
  • Salmeterol
  • Saquinavir
  • Scopolamine
  • Secobarbital
  • Selegiline
  • Selexipag
  • Selpercatinib
  • Semaglutide
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Iodide
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sorbitol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sufentanil
  • Sulfonylureas
  • Sumatriptan
  • Suvorexant
  • Tacrine
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Terbinafine
  • Terbutaline
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Ticagrelor
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolcapone
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Triprolidine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vasodilators
  • Vasopressors
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem