Chlorcyclizine

Chlorcyclizine Brand Name– AHIST

What is Chlorcyclizine

Chlorcyclizine is an oral sedating, phenylpiperazine antihistamine (H1-blocker) that is structurally related to cyclizine, hydroxyzine, and meclizine.

Chlorcyclizine is effective in treating symptoms due to hay fever and other upper respiratory allergies.

It has also been used to relieve urticaria, pruritus, and emesis.

Indications

  1. allergic rhinitis
  2. ocular pruritus
  3. rhinorrhea
  4. sneezing

For the treatment of symptoms due to hay fever or allergic rhinitis, such as rhinorrhea, sneezing, throat, nasal or ocular pruritus, or watery eyes

Side Effects

  1. abdominal pain
  2. asthenia
  3. blurred vision
  4. bronchial secretions
  5. coma
  6. confusion
  7. constipation
  8. contact dermatitis
  9. diarrhea
  10. dizziness
  11. drowsiness
  12. dysarthria
  13. dyskinesia
  14. dystonic reaction
  15. euphoria
  16. excitability
  17. fatigue
  18. hallucinations
  19. headache
  20. hypotension
  21. impaired cognition
  22. insomnia
  23. mydriasis
  24. nausea
  25. palpitations
  26. pruritus
  27. psychosis
  28. rash
  29. restlessness
  30. seizures
  31. sinus tachycardia
  32. tardive dyskinesia
  33. tremor
  34. urinary retention
  35. urticaria
  36. vomiting
  37. weakness
  38. xerophthalmia
  39. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticholinergic medications
  • asthma
  • bladder obstruction
  • breast-feeding
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • driving or operating machinery
  • ethanol intoxication
  • geriatric
  • ileus
  • infants
  • neonates
  • pregnancy
  • prostatic hypertrophy
  • urinary retention

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Belladonna; Opium
  • Benzodiazepines
  • Benzphetamine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorzoxazone
  • Clobazam
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Daratumumab; Hyaluronidase
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dronabinol
  • Droperidol
  • Entacapone
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Ibuprofen; Oxycodone
  • Isocarboxazid
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lithium
  • Loperamide
  • Loperamide; Simethicone
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Metoclopramide
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Olanzapine
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Phenelzine
  • Pimozide
  • Pitolisant
  • Pramipexole
  • Pregabalin
  • Procarbazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Selegiline
  • Sincalide
  • Sodium Iodide
  • Solifenacin
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tasimelteon
  • Thalidomide
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trimethobenzamide
  • Trospium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
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