Chloral Hydrate

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Chloral Hydrate Brand Names

Aquachoral Supprettes | Somnote

What is Chloral Hydrate

Chloral hydrate is an orally or rectally administered sedative/hypnotic. It is used primarily as an alternative to benzodiazepines in the short-term treatment of insomnia.

Tolerance to the hypnotic effects limits its effectiveness for periods longer than 2 weeks.

Chloral hydrate also is used to promote conscious sedation during pediatric dental procedures, preoperatively to relieve anxiety and to induce sedation, and postoperatively as an adjunct to analgesics or opiates.

Chloral hydrate has been used as a routine sedative; however, its use has declined as a result of the development of safer and more effective agents.

In use for many years, chloral hydrate was approved by the FDA in 1938.

Indications

  1. insomnia
  2. procedural sedation
  3. sedation maintenance

Side Effects

  1. angioedema
  2. apnea
  3. asthenia
  4. ataxia
  5. atopic dermatitis
  6. bradycardia
  7. bullous rash
  8. complex sleep-related behaviors
  9. confusion
  10. delirium
  11. depression
  12. diarrhea
  13. dizziness
  14. drowsiness
  15. dysgeusia
  16. erythema multiforme
  17. fever
  18. gastritis
  19. headache
  20. hypotension
  21. hypoxia
  22. impaired cognition
  23. jaundice
  24. lethargy
  25. memory impairment
  26. nausea
  27. physiological dependence
  28. proteinuria
  29. psychological dependence
  30. purpura
  31. rash
  32. respiratory depression
  33. somnambulism
  34. suicidal ideation
  35. tolerance
  36. urticaria
  37. vertigo
  38. vomiting
  39. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • breast-feeding
  • cardiac disease
  • colitis
  • complex sleep-related behaviors
  • depression
  • driving or operating machinery
  • esophagitis
  • gastritis
  • geriatric
  • hepatic disease
  • infants
  • mannitol hypersensitivity
  • neonates
  • paraben hypersensitivity
  • peptic ulcer disease
  • porphyria
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • substance abuse
  • suicidal ideation

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aldesleukin, IL-2
  • Alfentanil
  • Amoxapine
  • Apomorphine
  • Apraclonidine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benztropine
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorzoxazone
  • Clobazam
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Cyclobenzaprine
  • Dantrolene
  • Deutetrabenazine
  • Dexmedetomidine
  • Dicyclomine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disulfiram
  • Dronabinol
  • Esketamine
  • Ethanol
  • Ezogabine
  • Fentanyl
  • Furosemide
  • Gabapentin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Isocarboxazid
  • Lasmiditan
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lithium
  • Lofexidine
  • Lumateperone
  • Maprotiline
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Metaxalone
  • Methadone
  • Methocarbamol
  • Methscopolamine
  • Metoclopramide
  • Mirtazapine
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nalbuphine
  • Orphenadrine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Papaverine
  • Perampanel
  • Phenelzine
  • Phenothiazines
  • Phentermine; Topiramate
  • Pramipexole
  • Pregabalin
  • Propoxyphene
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Ropinirole
  • Rotigotine
  • Safinamide
  • Scopolamine
  • Selegiline
  • Sodium Oxybate
  • Sufentanil
  • Suvorexant
  • Tapentadol
  • Tetrabenazine
  • Thalidomide
  • Tizanidine
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Valerian, Valeriana officinalis
  • Vigabatrin
  • Vilazodone
  • Warfarin
  • Ziconotide

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