Chlorambucil

Chlorambucil Brand Name– Leukeran

What is Chlorambucil

Chlorambucil is an oral alkylating agent. Chlorambucil is approved for use as palliative treatment of chronic lymphocytic leukemia, Hodgkin lymphoma, and certain non-Hodgkin’s lymphomas including lymphosarcoma and giant follicular lymphoma.

It is a stable derivative of mechlorethamine and exhibits less antineoplastic activity than mechlorethamine but also less toxicity.

Indications

  1. Behcet’s syndrome
  2. chronic lymphocytic leukemia (CLL)
  3. Churg-Strauss syndrome
  4. dermatomyositis
  5. Hodgkin lymphoma
  6. immune thrombocytopenic purpura (ITP)
  7. lupus nephritis
  8. macroglobulinemia
  9. nephrotic syndrome
  10. non-Hodgkin’s lymphoma (NHL)
  11. pneumonitis
  12. polyarteritis nodosa
  13. polymyositis
  14. rheumatoid arthritis
  15. systemic lupus erythematosus (SLE)
  16. uveitis
  17. Wegener’s granulomatosis

For the treatment of chronic lymphocytic leukemia (CLL)

for the palliative treatment of CLL

Side Effects

  1. agitation
  2. amenorrhea
  3. anemia
  4. angioedema
  5. ataxia
  6. azoospermia
  7. bone marrow suppression
  8. confusion
  9. cystitis
  10. diarrhea
  11. elevated hepatic enzymes
  12. erythema multiforme
  13. fever
  14. gonadal suppression
  15. hallucinations
  16. infertility
  17. jaundice
  18. leukopenia
  19. lymphopenia
  20. myoclonia
  21. nausea
  22. neutropenia
  23. new primary malignancy
  24. oral ulceration
  25. pancytopenia
  26. paresis
  27. peripheral neuropathy
  28. pneumonitis
  29. pulmonary fibrosis
  30. rash
  31. seizures
  32. Stevens-Johnson syndrome
  33. teratogenesis
  34. thrombocytopenia
  35. toxic epidermal necrolysis
  36. tremor
  37. urticaria
  38. vomiting

Monitoring Parameters

  • CBC with differential
  • LFTs

Contraindications

  • anemia
  • bone marrow suppression
  • breast-feeding
  • head trauma
  • hepatic disease
  • infertility
  • leukopenia
  • neutropenia
  • new primary malignancy
  • pregnancy
  • radiation therapy
  • seizure disorder
  • serious rash
  • thrombocytopenia
  • vaccination

Interactions

  • Abciximab
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Alteplase
  • Amlodipine; Celecoxib
  • Amobarbital
  • Anagrelide
  • Anticoagulants
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Argatroban
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Dipyridamole
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Budesonide
  • Budesonide; Formoterol
  • Butabarbital
  • Carbamazepine
  • Celecoxib
  • Ciclesonide
  • Cilostazol
  • Clopidogrel
  • Clozapine
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Dabigatran
  • Daclizumab
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desirudin
  • Dexamethasone
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dipyridamole
  • Echinacea
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Febuxostat
  • Fenoprofen
  • Filgrastim, G-CSF
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fondaparinux
  • Formoterol; Mometasone
  • Heparin
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indomethacin
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lepirudin
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Mephobarbital
  • Methohexital
  • Methylprednisolone
  • Mometasone
  • Mycophenolate
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nonsteroidal antiinflammatory drugs
  • Oxaprozin
  • Palifermin
  • Penicillamine
  • Pentobarbital
  • Pentosan
  • Phenobarbital
  • Piroxicam
  • Platelet Inhibitors
  • Prasugrel
  • Prednisolone
  • Prednisone
  • Primidone
  • Reteplase, r-PA
  • Rivaroxaban
  • Rofecoxib
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Secobarbital
  • Sirolimus
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Streptokinase
  • Sulindac
  • Tacrolimus
  • Tbo-Filgrastim
  • Tenecteplase
  • Thiopental
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Tolmetin
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Typhoid Vaccine
  • Urokinase
  • Valdecoxib
  • Varicella-Zoster Virus Vaccine, Live
  • Vorapaxar
  • Warfarin
  • Yellow Fever Vaccine, Live
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