Chlorambucil Brand Name– Leukeran
What is Chlorambucil
Chlorambucil is an oral alkylating agent. Chlorambucil is approved for use as palliative treatment of chronic lymphocytic leukemia, Hodgkin lymphoma, and certain non-Hodgkin’s lymphomas including lymphosarcoma and giant follicular lymphoma.
It is a stable derivative of mechlorethamine and exhibits less antineoplastic activity than mechlorethamine but also less toxicity.
Indications
- Behcet’s syndrome
- chronic lymphocytic leukemia (CLL)
- Churg-Strauss syndrome
- dermatomyositis
- Hodgkin lymphoma
- immune thrombocytopenic purpura (ITP)
- lupus nephritis
- macroglobulinemia
- nephrotic syndrome
- non-Hodgkin’s lymphoma (NHL)
- pneumonitis
- polyarteritis nodosa
- polymyositis
- rheumatoid arthritis
- systemic lupus erythematosus (SLE)
- uveitis
- Wegener’s granulomatosis
For the treatment of chronic lymphocytic leukemia (CLL)
for the palliative treatment of CLL
Side Effects
- agitation
- amenorrhea
- anemia
- angioedema
- ataxia
- azoospermia
- bone marrow suppression
- confusion
- cystitis
- diarrhea
- elevated hepatic enzymes
- erythema multiforme
- fever
- gonadal suppression
- hallucinations
- infertility
- jaundice
- leukopenia
- lymphopenia
- myoclonia
- nausea
- neutropenia
- new primary malignancy
- oral ulceration
- pancytopenia
- paresis
- peripheral neuropathy
- pneumonitis
- pulmonary fibrosis
- rash
- seizures
- Stevens-Johnson syndrome
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- tremor
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- head trauma
- hepatic disease
- infertility
- leukopenia
- neutropenia
- new primary malignancy
- pregnancy
- radiation therapy
- seizure disorder
- serious rash
- thrombocytopenia
- vaccination
Interactions
- Abciximab
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Alteplase
- Amlodipine; Celecoxib
- Amobarbital
- Anagrelide
- Anticoagulants
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Dipyridamole
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Carbamazepine
- Celecoxib
- Ciclesonide
- Cilostazol
- Clopidogrel
- Clozapine
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Dabigatran
- Daclizumab
- Dalteparin
- Danaparoid
- Deflazacort
- Desirudin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dipyridamole
- Echinacea
- Edoxaban
- Enoxaparin
- Eptifibatide
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mephobarbital
- Methohexital
- Methylprednisolone
- Mometasone
- Mycophenolate
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Penicillamine
- Pentobarbital
- Pentosan
- Phenobarbital
- Piroxicam
- Platelet Inhibitors
- Prasugrel
- Prednisolone
- Prednisone
- Primidone
- Reteplase, r-PA
- Rivaroxaban
- Rofecoxib
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Secobarbital
- Sirolimus
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Streptokinase
- Sulindac
- Tacrolimus
- Tbo-Filgrastim
- Tenecteplase
- Thiopental
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Tolmetin
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Urokinase
- Valdecoxib
- Varicella-Zoster Virus Vaccine, Live
- Vorapaxar
- Warfarin
- Yellow Fever Vaccine, Live
