Cefiderocol Brand Name– FETROJA
What is Cefiderocol
Cefiderocol is a parenteral siderophore cephalosporin antibacterial indicated for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis, in adults who have limited or no treatment options.
Approval of cefiderocol for this indication is based on limited clinical safety and efficacy data. In a multinational, randomized, open-label trial in critically-ill patients with carbapenem-resistant gram-negative bacterial infections, an increase in all-cause mortality was observed in patients receiving cefiderocol compared to those receiving best available therapy.
Patients with nosocomial pneumonia, bloodstream infections, sepsis, or cUTIs were included in the trial. The increase in all-cause mortality occurred in patients treated for nosocomial pneumonia, bloodstream infections, or sepsis.
Generally, death occurred in patients with infections caused by gram-negative organisms and was the result of worsening or complications of infection or underlying comorbidities.
The cause of the increase in mortality has not been established. Safety and efficacy of cefiderocol has not been established for the treatment of nosocomial pneumonia, bloodstream infections, or sepsis.
Cefiderocol functions as a siderophore and binds to extracellular free ferric iron. In addition to passive diffusion via porin channels, cefiderocol is actively transported across the outer cell membrane of bacteria into the periplasmic space using a siderophore iron uptake mechanism.
Indications
- Acinetobacter baumannii
- Citrobacter freundii
- Citrobacter koseri
- Enterobacter cloacae
- Escherichia coli
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Pseudomonas aeruginosa
- pyelonephritis
- Serratia marcescens
- Stenotrophomonas maltophilia
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- anaphylactoid reactions
- anorexia
- asterixis
- atrial fibrillation
- bradycardia
- candidiasis
- cholecystitis
- cholelithiasis
- coma
- constipation
- cough
- diarrhea
- dysgeusia
- dyspnea
- elevated hepatic enzymes
- encephalopathy
- erythema
- fever
- headache
- heart failure
- hypocalcemia
- hypokalemia
- injection site reaction
- insomnia
- maculopapular rash
- myoclonia
- nausea
- peripheral edema
- phlebitis
- pleural effusion
- pruritus
- pseudomembranous colitis
- rash
- restlessness
- seizures
- skin irritation
- stomatitis
- superinfection
- thrombocytosis
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- dialysis
- diarrhea
- geriatric
- hypoprothrombinemia
- laboratory test interference
- mortality
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- seizure disorder
- seizures
- vitamin K deficiency
Interactions
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
