Cefixime Brand Name– Suprax
What is Cefixime
Cefixime is a third-generation cephalosporin available in an oral formulation. In general, third-generation cephalosporins are more active against gram-negative species than are the earlier generations of cephalosporins.
Like ceftriaxone and cefotaxime, cefixime has enhanced antibacterial activity and increased stability against many of the beta-lactamases.
Cefixime is commonly used in the treatment of otitis media, respiratory tract infections, and urinary tract infections caused by susceptible organisms.
Cefixime was approved by the FDA in April 1989.
In July 2002, Wyeth Pharmaceuticals discontinued the manufacture of cefixime (Suprax) in the US.
The patent for cefixime expired on November 10, 2002. Wyeth continued to sell cefixime until March 31, 2003.
Lupin pharmaceutical company received FDA approval in February 2004 to market Suprax tablets and oral suspension. A chewable tablet was approved in June 2004.
Indications
- bronchitis
- cervicitis
- Citrobacter amalonaticus
- Citrobacter diversus
- community-acquired pneumonia
- Escherichia coli
- febrile neutropenia
- gonorrhea
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Moraxella catarrhalis
- Neisseria gonorrhoeae
- otitis media
- Pasteurella multocida
- pharyngitis
- pneumonia
- Proteus mirabilis
- Proteus vulgaris
- Providencia sp.
- pyelonephritis
- Salmonella sp.
- Serratia marcescens
- Shigella sp.
- sinusitis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- tonsillitis
- typhoid fever
- urethritis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- aplastic anemia
- arthralgia
- azotemia
- bleeding
- candidiasis
- cholestasis
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- flatulence
- headache
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hypoprothrombinemia
- jaundice
- leukopenia
- maculopapular rash
- nausea
- neutropenia
- pancytopenia
- pruritus
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- dialysis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- neonates
- penicillin hypersensitivity
- phenylketonuria
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- sexually transmitted disease
- ulcerative colitis
- vitamin K deficiency
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Aminosalicylate sodium, Aminosalicylic acid
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Carbamazepine
- Choline Salicylate; Magnesium Salicylate
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Magnesium Salicylate
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Salicylates
- Salsalate
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
