Cefixime

Cefixime Brand Name– Suprax

What is Cefixime

Cefixime is a third-generation cephalosporin available in an oral formulation. In general, third-generation cephalosporins are more active against gram-negative species than are the earlier generations of cephalosporins.

Like ceftriaxone and cefotaxime, cefixime has enhanced antibacterial activity and increased stability against many of the beta-lactamases.

Cefixime is commonly used in the treatment of otitis media, respiratory tract infections, and urinary tract infections caused by susceptible organisms.

Cefixime was approved by the FDA in April 1989.

In July 2002, Wyeth Pharmaceuticals discontinued the manufacture of cefixime (Suprax) in the US.

The patent for cefixime expired on November 10, 2002. Wyeth continued to sell cefixime until March 31, 2003.

Lupin pharmaceutical company received FDA approval in February 2004 to market Suprax tablets and oral suspension. A chewable tablet was approved in June 2004.

Indications

  1. bronchitis
  2. cervicitis
  3. Citrobacter amalonaticus
  4. Citrobacter diversus
  5. community-acquired pneumonia
  6. Escherichia coli
  7. febrile neutropenia
  8. gonorrhea
  9. Haemophilus influenzae (beta-lactamase negative)
  10. Haemophilus influenzae (beta-lactamase positive)
  11. Haemophilus parainfluenzae
  12. Klebsiella oxytoca
  13. Klebsiella pneumoniae
  14. Moraxella catarrhalis
  15. Neisseria gonorrhoeae
  16. otitis media
  17. Pasteurella multocida
  18. pharyngitis
  19. pneumonia
  20. Proteus mirabilis
  21. Proteus vulgaris
  22. Providencia sp.
  23. pyelonephritis
  24. Salmonella sp.
  25. Serratia marcescens
  26. Shigella sp.
  27. sinusitis
  28. Streptococcus agalactiae (group B streptococci)
  29. Streptococcus pneumoniae
  30. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  31. tonsillitis
  32. typhoid fever
  33. urethritis
  34. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. angioedema
  6. aplastic anemia
  7. arthralgia
  8. azotemia
  9. bleeding
  10. candidiasis
  11. cholestasis
  12. diarrhea
  13. dizziness
  14. dyspepsia
  15. elevated hepatic enzymes
  16. eosinophilia
  17. erythema multiforme
  18. flatulence
  19. headache
  20. hemolytic anemia
  21. hepatitis
  22. hyperbilirubinemia
  23. hypoprothrombinemia
  24. jaundice
  25. leukopenia
  26. maculopapular rash
  27. nausea
  28. neutropenia
  29. pancytopenia
  30. pruritus
  31. pseudomembranous colitis
  32. rash
  33. renal failure (unspecified)
  34. seizures
  35. serum sickness
  36. Stevens-Johnson syndrome
  37. superinfection
  38. thrombocytopenia
  39. toxic epidermal necrolysis
  40. urticaria
  41. vaginitis
  42. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • phenylketonuria
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • sexually transmitted disease
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Aminosalicylate sodium, Aminosalicylic acid
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Carbamazepine
  • Choline Salicylate; Magnesium Salicylate
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Magnesium Salicylate
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Salicylates
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin
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