Carbinoxamine Pseudoephedrine

Carbinoxamine Pseudoephedrine Brand Names

Andehist | Andehist NR | Carbaxefed RF | Carbic D | Carbofed | Carboxine 12 D | Carboxine PSE | Carboxine-D | Cardec | Cardec S | Cardec TR | Coldec | Coldec D | Coldec DS | Coldec TR | Cordron D | Cordron D NR | Cordron-12 D | Cydec | Hydro-Tussin CBX | Mintex PSE | Palgic D | Pediatex 12 D | Pediatex D | Pediatex-JR | Pseudo Carb | Rondamine | Rondamine TR | Rondec | Rondec TR | Sildec

What is Carbinoxamine Pseudoephedrine

NOTE: These products are discontinued in the U.S

Carbinoxamine and pseudoephedrine are used together in an oral preparation for symptomatic relief of seasonal and perennial allergic rhinitis and vasomotor rhinitis.

Carbinoxamine is a sedating antihistamine (H1-blocker) of the ethanolamine class. It dries the nasal and sinus passages secondary to its anticholinergic activity.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha1-adrenergic receptors in vascular smooth muscle. This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency. Carbinoxamine has been available since before 1938, prior to the modern FDA drug-approval process.

As part of an FDA initiative to ensure that all prescription and non-prescription medications are FDA-approved, manufacturers of non-approved carbinoxamine products (single and multi-ingredient) must submit an application showing safety and efficacy to continue distribution and sales.

Due to deaths reported in very young children and infants, these products are contraindicated in pediatric patients 2 years of age and younger.

What are the indications

1. allergic rhinitis
2. nasal congestion
3. vasomotor rhinitis

What are the side Effects

1. angina
2. anorexia
3. ataxia
4. diarrhea
5. diplopia
6. dizziness
7. drowsiness
8. dyspepsia
9. dysuria
10. hallucinations
11. headache
12. hypertension
13. hypertensive crisis
14. insomnia
15. myocardial infarction
16. nausea
17. pallor
18. palpitations
19. polyuria
20. premature ventricular contractions (PVCs)
21. psychosis
22. restlessness
23. seizures
24. sinus tachycardia
25. stroke
26. tremor
27. vomiting
28. weakness
29. xerophthalmia
30. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

What are the contraindications

• acute myocardial infarction
• angina
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intraocular pressure
• infants
• MAOI therapy
• neonates
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• status asthmaticus
• tachycardia
• tobacco smoking
• urinary retention

What are the drug to drug interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambenonium Chloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Arformoterol
• Aripiprazole
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzodiazepines
• Benzphetamine
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carisoprodol
• Carteolol
• Carvedilol
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Clevidipine
• Clobazam
• Clonidine
• Clozapine
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Cyclobenzaprine
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Desloratadine
• Desloratadine; Pseudoephedrine
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Dronabinol
• Droperidol
• Droxidopa
• Dulaglutide
• Dyphylline
• Dyphylline; Guaifenesin
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Entacapone
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esmolol
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Exenatide
• Ezogabine
• Felodipine
• Fentanyl
• Flibanserin
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Furosemide
• Gabapentin
• Galantamine
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Ibuprofen; Oxycodone
• Iloperidone
• Iloprost
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Isocarboxazid
• Isradipine
• Ketamine
• Labetalol
• Lasmiditan
• Lemborexant
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levomethadyl
• Levorphanol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine
• Loratadine; Pseudoephedrine
• Loxapine
• Lumateperone
• Lurasidone
• Macitentan
• Magnesium Salts
• Maprotiline
• Mecamylamine
• Meclizine
• Meglitinides
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaproterenol
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methocarbamol
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylergonovine
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midodrine
• Miglitol
• Minocycline
• Mirtazapine
• Mitotane
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nalbuphine
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Norepinephrine
• Olanzapine
• Opiate Agonists
• Orphenadrine
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Paroxetine
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine
• Phenylephrine; Promethazine
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Pregabalin
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Propranolol
• Quetiapine
• Quinapril
• Racepinephrine
• Ramelteon
• Ramipril
• Rasagiline
• Remifentanil
• Reserpine
• Riociguat
• Risperidone
• Rituximab; Hyaluronidase
• Rivastigmine
• Ropinirole
• Rosiglitazone
• Safinamide
• Salmeterol
• Secobarbital
• Selegiline
• Selexipag
• Semaglutide
• SGLT2 Inhibitors
• Sibutramine
• Sincalide
• Sodium Iodide
• Solifenacin
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Suvorexant
• Tacrine
• Tasimelteon
• Terbutaline
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Timolol
• Tizanidine
• Tolcapone
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trospium
• Umeclidinium; Vilanterol
• Vasodilators
• Vasopressors
• Verapamil
• Vigabatrin
• Vilazodone
• Yohimbine
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem