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Carbinoxamine Phenylephrine Brand Names
Aridex-D | Histamax D | Norel LA | X-Hist | XiraHist
What is Carbinoxamine Phenylephrine
Carbinoxamine and phenylephrine are used together for the symptomatic relief of upper respiratory symptoms such as nasal congestion, rhinorrhea, and sneezing associated with allergic rhinitis or the common cold.
Carbinoxamine is a first generation H1-antagonist of the ethanolamine class commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing. In general, antihistamines from the ethanolamine class produce more sedation and exhibit greater anticholinergic activity than antihistamines from other classes.
Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.
Phenylephrine appears to have a lower propensity to cause hypertension and potential sequelae (e.g., stroke, hypertensive crisis, intracranial bleeding) than ephedrine or phenylpropanolamine.
Carbinoxamine phenylephrine is available in extended-release tablets (e.g., Norel® LA), and pediatric oral liquid preparations (e.g., HistamaxD® drops, XiraHist™ pediatric drops).
Indications
- allergic rhinitis
- nasal congestion
- rhinorrhea
Side Effects
- abdominal pain
- angina
- anorexia
- anxiety
- arrhythmia exacerbation
- ataxia
- blurred vision
- bronchial secretions
- diarrhea
- diplopia
- dizziness
- drowsiness
- dyspepsia
- dysuria
- excitability
- hallucinations
- headache
- hypertension
- hypertensive crisis
- hyperthermia
- hypotension
- insomnia
- irritability
- mydriasis
- myocardial infarction
- nausea
- pallor
- palpitations
- photophobia
- photosensitivity
- polyuria
- premature ventricular contractions (PVCs)
- pruritus
- psychosis
- rash
- restlessness
- seizures
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- tremor
- urinary retention
- urticaria
- visual impairment
- vomiting
- weakness
- wheezing
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acute myocardial infarction
- aneurysm
- angina
- anticholinergic medications
- arteriosclerosis
- asthma
- atrial fibrillation
- atrial flutter
- AV block
- bladder obstruction
- bradycardia
- breast-feeding
- bundle-branch block
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- contact lenses
- coronary artery disease
- diabetes mellitus
- driving or operating machinery
- geriatric
- GI disease
- GI obstruction
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intraocular pressure
- infants
- intracranial bleeding
- labor
- MAOI therapy
- myocardial infarction
- neonates
- obstetric delivery
- organic brain syndrome
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- pyloric stenosis
- renal disease
- renal failure
- renal impairment
- status asthmaticus
- stroke
- tachycardia
- thyroid disease
- thyrotoxicosis
- ulcerative colitis
- urinary retention
- ventricular fibrillation
- ventricular tachycardia
Interactions
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-blockers
- Alpha-glucosidase Inhibitors
- Alprazolam
- Amantadine
- Ambenonium Chloride
- Ambrisentan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Apomorphine
- Arformoterol
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzphetamine
- Beta-blockers
- Betamethasone
- Betaxolol
- Bethanechol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Bretylium
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capsaicin; Metaxalone
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Carisoprodol
- Carteolol
- Carvedilol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Ciclesonide
- Clevidipine
- Clobazam
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- COMT inhibitors
- Corticosteroids
- Cortisone
- Cyclobenzaprine
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Deflazacort
- Desloratadine
- Desloratadine; Pseudoephedrine
- Desmopressin
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Diazepam
- Diethylpropion
- Digitoxin
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Dipeptidyl Peptidase-4 Inhibitors
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Dorzolamide; Timolol
- Doxazosin
- Dronabinol
- Droperidol
- Dulaglutide
- Dyphylline
- Dyphylline; Guaifenesin
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Ertugliflozin
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Esmolol
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Etomidate
- Exenatide
- Ezogabine
- Felodipine
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fludrocortisone
- Flunisolide
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol
- Formoterol; Mometasone
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Furosemide
- Gabapentin
- Galantamine
- Ginger, Zingiber officinale
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Halogenated Anesthetics
- Haloperidol
- Halothane
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Degludec; Liraglutide
- Insulin Glargine; Lixisenatide
- Insulins
- Iobenguane I 131
- Ionic Contrast Media
- Isocarboxazid
- Isoflurane
- Isradipine
- Ketamine
- Labetalol
- Lasmiditan
- Lemborexant
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levomethadyl
- Levorphanol
- Levothyroxine
- Levothyroxine; Liothyronine (Porcine)
- Levothyroxine; Liothyronine (Synthetic)
- Linagliptin; Metformin
- Linezolid
- Liothyronine
- Liraglutide
- Lithium
- Lixisenatide
- Loop diuretics
- Loratadine
- Loratadine; Pseudoephedrine
- Lorazepam
- Loxapine
- Lumateperone
- Lurasidone
- Macitentan
- Magnesium Salts
- Maprotiline
- Mecamylamine
- Meclizine
- Meglitinides
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Meprobamate
- Metaproterenol
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methocarbamol
- Methohexital
- Methyclothiazide
- Methyldopa
- Methylergonovine
- Methylphenidate
- Methylprednisolone
- Methysergide
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrapone
- Metyrosine
- Midazolam
- Midodrine
- Miglitol
- Minocycline
- Mirtazapine
- Mitotane
- Molindone
- Mometasone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nafarelin
- Nalbuphine
- Naproxen; Pseudoephedrine
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nicardipine
- Nicotine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitrates
- Non-Ionic Contrast Media
- Olanzapine
- Opiate Agonists
- Orphenadrine
- Oxazepam
- Oxycodone
- Oxymorphone
- Oxytocin
- Ozanimod
- Paliperidone
- Paroxetine
- Penbutolol
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine; Promethazine
- Phosphodiesterase inhibitors
- Pimozide
- Pindolol
- Pioglitazone
- Pirbuterol
- Pitolisant
- Potassium-sparing diuretics
- Pramipexole
- Pramlintide
- Prazosin
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Propranolol
- Pseudoephedrine
- Quazepam
- Quetiapine
- Racepinephrine
- Ramelteon
- Rasagiline
- Remifentanil
- Reserpine
- Riociguat
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Ropinirole
- Rosiglitazone
- Safinamide
- Salmeterol
- Secobarbital
- Selegiline
- Selexipag
- Semaglutide
- Sevoflurane
- SGLT2 Inhibitors
- Sibutramine
- Sildenafil
- Sincalide
- Sodium Iodide
- Solifenacin
- Solriamfetol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfonylureas
- Suvorexant
- Tacrine
- Tadalafil
- Tasimelteon
- Temazepam
- Terazosin
- Terbutaline
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thyroid hormones
- Timolol
- Tizanidine
- Tolcapone
- Torsemide
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trospium
- Umeclidinium; Vilanterol
- Vardenafil
- Vasodilators
- Verapamil
- Vigabatrin
- Vilazodone
- Yohimbine
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolpidem