Carbinoxamine Dextromethorphan Pseudoephedrine

Carbinoxamine Dextromethorphan Pseudoephedrine Brand Names

Andehist DM | Andehist DM NR | Balamine DM | Carb PSE 12 DM | Carbaxefed DM RF

What is Carbinoxamine Dextromethorphan Pseudoephedrine

NOTE: These products are discontinued in the U.S.

Carbinoxamine dextromethorphan pseudoephedrine are used together in an oral preparation to treat upper respiratory congestion and to relieve coughing associated with allergy or the common cold.

Carbinoxamine is a sedating antihistamine (H1-blocker) of the ethanolamine class. It dries the nasal and sinus passages secondary to its anticholinergic activity.

Dextromethorphan is a centrally acting cough suppressant used to inhibit dry, nonproductive coughs.

Pseudoephedrine is a sympathomimetic agent that relieves nasal and sinus congestion and produces little or no rebound congestion, unlike topically applied sympathomimetics.

Carbinoxamine-containing products were marketed prior to the modern FDA drug-approval process. As part of an FDA initiative to ensure that all prescription and non-prescription medications are FDA-approved, manufacturers of non-approved carbinoxamine products (single and multi-ingredient) must submit an application showing safety and efficacy to continue distribution and sales.

Due to reports of death among young children and infants; these products are contraindicated in pediatric patients less than 2 years of age.

Indications

1. allergic rhinitis
2. common cold
3. cough
4. nasal congestion

For relief of cough and upper respiratory symptoms, including nasal congestion, due to allergic rhinitis or the common cold

Side Effects

1. angina
2. anorexia
3. ataxia
4. blurred vision
5. confusion
6. diarrhea
7. diplopia
8. dizziness
9. drowsiness
10. dysarthria
11. dyspepsia
12. dysuria
13. fatigue
14. hallucinations
15. headache
16. hypertension
17. insomnia
18. irritability
19. myocardial infarction
20. nausea
21. pallor
22. palpitations
23. polyuria
24. premature ventricular contractions (PVCs)
25. psychosis
26. rash
27. respiratory depression
28. restlessness
29. seizures
30. serotonin syndrome
31. sinus tachycardia
32. stroke
33. tremor
34. urticaria
35. vomiting
36. weakness
37. xerophthalmia
38. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• angina
• asthma
• bladder obstruction
• breast-feeding
• bronchitis
• cardiac disease
• cardiomyopathy
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• geriatric
• GI obstruction
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intraocular pressure
• infants
• MAOI therapy
• myocardial infarction
• neonates
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• status asthmaticus
• tobacco smoking
• urinary retention

Interactions

• Abiraterone
• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambenonium Chloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Amiodarone
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Arformoterol
• Aripiprazole
• Artemether; Lumefantrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzphetamine
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Cardiac glycosides
• Carisoprodol
• Carteolol
• Carvedilol
• Celecoxib
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cinacalcet
• Citalopram
• Clevidipine
• Clobazam
• Clonidine
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Cyclobenzaprine
• Dacomitinib
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Darifenacin
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Delavirdine
• Desloratadine
• Desloratadine; Pseudoephedrine
• Desvenlafaxine
• Dexmedetomidine
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Dronabinol
• Dronedarone
• Droperidol
• Droxidopa
• Dulaglutide
• Duloxetine
• Dyphylline
• Dyphylline; Guaifenesin
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Entacapone
• Ephedrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esmolol
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Exenatide
• Ezogabine
• Fedratinib
• Felodipine
• Fentanyl
• Flibanserin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Furosemide
• Gabapentin
• Galantamine
• Ginger, Zingiber officinale
• Givosiran
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• grapefruit juice
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Iloperidone
• Iloprost
• Imatinib
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Isocarboxazid
• Isradipine
• Ketamine
• Labetalol
• Lasmiditan
• Lemborexant
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Loratadine
• Loratadine; Pseudoephedrine
• Lorcaserin
• Loxapine
• Lumateperone
• Lurasidone
• Macitentan
• Magnesium Salts
• Maprotiline
• Mecamylamine
• Meclizine
• Meglitinides
• Melatonin
• Memantine
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaproterenol
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methazolamide
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midodrine
• Miglitol
• Milnacipran
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nalbuphine
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Norepinephrine
• Olanzapine
• Opiate Agonists
• Oritavancin
• Orphenadrine
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Panobinostat
• Paroxetine
• Pazopanib
• Peginterferon Alfa-2b
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine
• Phenylephrine; Promethazine
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Pregabalin
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propofol
• Propoxyphene
• Propranolol
• Quetiapine
• Quinapril
• Quinine
• Racepinephrine
• Ramelteon
• Ramipril
• Rasagiline
• Remifentanil
• Reserpine
• Riociguat
• Risperidone
• Rituximab; Hyaluronidase
• Rivastigmine
• Rolapitant
• Ropinirole
• Rosiglitazone
• Safinamide
• Salmeterol
• Secobarbital
• Selegiline
• Selexipag
• Semaglutide
• Serotonin-Receptor Agonists
• Sertraline
• SGLT2 Inhibitors
• Sibutramine
• Sincalide
• Sodium Iodide
• Solifenacin
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Sufentanil
• Sulfonylureas
• Suvorexant
• Tacrine
• Tasimelteon
• Tedizolid
• Terbinafine
• Terbutaline
• Thalidomide
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Thyroid hormones
• Timolol
• Tizanidine
• Tocilizumab
• Tolcapone
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trospium
• Umeclidinium; Vilanterol
• Vasodilators
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• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Vortioxetine
• Yohimbine
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• Ziprasidone
• Zolpidem