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Carbinoxamine Hydrocodone Pseudoephedrine Brand Names
Histex HC | Mintex HC | Tri-Vent HC
What is Carbinoxamine Hydrocodone Pseudoephedrine
NOTE: These products are discontinued in the U.S.
Carbinoxamine hydrocodone pseudoephedrine are used together for symptomatic relief of cough, rhinorrhea, and nasal congestion associated with allergies or upper respiratory infections.
Carbinoxamine is an oral sedating antihistamine (H1-blocker) of the ethanolamine class that dries the nasal and sinus passages secondary to its anticholinergic activity. Hydrocodone, similar to codeine, is an opiate used for cough suppression.
The antitussive and sedative properties of hydrocodone are greater than those of codeine.
Pseudoephedrine is a sympathomimetic that stimulates alpha1-adrenergic receptors in vascular smooth muscle, which results in vasoconstriction and shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency. Thus, decreased nasal congestion occurs.
Carbinoxamine; hydrocodone; pseudoephedrine formulations were prescription only products.
Carbinoxamine was developed and marketed prior to the modern FDA drug-approval process.
As part of an FDA initiative to ensure that all prescription and non-prescription medications are FDA-approved, manufacturers of non-approved carbinoxamine-containing products must submit an application showing safety and efficacy to continue distribution and sales.
Indications
- allergic rhinitis
- common cold
- cough
- nasal congestion
- rhinorrhea
For symptomatic relief of cough, nasal congestion, and rhinorrhea associated with the common cold, allergic rhinitis, or other upper respiratory conditions
Side Effects
- abdominal pain
- angina
- anorexia
- anxiety
- arrhythmia exacerbation
- ataxia
- blurred vision
- confusion
- constipation
- diarrhea
- diplopia
- dizziness
- drowsiness
- dyspepsia
- dysphoria
- dysuria
- emotional lability
- euphoria
- excitability
- hallucinations
- headache
- hypertension
- hypertensive crisis
- hyperthermia
- impaired cognition
- increased intracranial pressure
- insomnia
- irritability
- lethargy
- mydriasis
- myocardial infarction
- nausea
- palpitations
- photophobia
- photosensitivity
- premature ventricular contractions (PVCs)
- pruritus
- psychological dependence
- psychosis
- rash
- respiratory depression
- restlessness
- seizures
- sinus tachycardia
- stroke
- supraventricular tachycardia (SVT)
- tremor
- urinary retention
- urticaria
- visual impairment
- vomiting
- weakness
- wheezing
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- acute abdomen
- acute myocardial infarction
- angina
- anticholinergic medications
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- constipation
- contact lenses
- coronary artery disease
- depression
- diabetes mellitus
- diarrhea
- driving or operating machinery
- emphysema
- geriatric
- GI obstruction
- head trauma
- heart failure
- hepatic disease
- hypertension
- hyperthyroidism
- ileus
- increased intracranial pressure
- infants
- labor
- MAOI therapy
- myocardial infarction
- neonates
- opiate agonist hypersensitivity
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- prostatic hypertrophy
- renal failure
- renal impairment
- status asthmaticus
- substance abuse
- sunlight (UV) exposure
- tachycardia
- tobacco smoking
- ulcerative colitis
- urinary retention
Interactions
- Abiraterone
- Acarbose
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Acetazolamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Albiglutide
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Almotriptan
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
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- Alpha-glucosidase Inhibitors
- Alprazolam
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Alvimopan
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- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
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- Ciprofloxacin
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- Clarithromycin
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- Codeine; Promethazine
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- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dicyclomine
- Digitoxin
- Digoxin
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- Dihydroergotamine
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- Donepezil
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- Dyphylline; Guaifenesin
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- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
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- Enalapril, Enalaprilat
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- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
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- Erythromycin
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- Flutamide
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- Fluvoxamine
- Formoterol
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- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
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- Fospropofol
- Fostamatinib
- Frovatriptan
- Furosemide
- Gabapentin
- Galantamine
- General anesthetics
- Ginger, Zingiber officinale
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- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Granisetron
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guanabenz
- Guanfacine
- Halogenated Anesthetics
- Haloperidol
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- Hydrochlorothiazide, HCTZ; Lisinopril
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- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
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- Tizanidine
- Tolcapone
- Tolterodine
- Topiramate
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Triprolidine
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vasodilators
- Vasopressors
- Vemurafenib
- Venlafaxine
- Verapamil
- Vigabatrin
- Vilazodone
- Voriconazole
- Vortioxetine
- Voxelotor
- Yohimbine
- Zafirlukast
- Zaleplon
- Ziconotide
- Ziprasidone
- Zolmitriptan
- Zolpidem
