Bacitracin

Bacitracin Brand Names

AK-Tracin | BaciiM | Baci-Rx | Ocu-Tracin

What is Bacitracin

Bacitracin is an ophthalmic, parenteral, and topical polypeptide antibiotic indicated for superficial ocular infections involving the conjunctiva and/or cornea, infants with pneumonia and empyema due to susceptible staphylococci, and infection prevention in minor cuts, scrapes, or burns, respectively.

It is active mainly against gram-positive bacteria.

In January 2020, the FDA requested the voluntary withdrawal of bacitracin for injection from the market because other effective FDA-approved treatments are available that do not have the same serious risks, including nephrotoxicity, anaphylactic reactions, and the need for repeated intramuscular injections.

Indications

  1. Actinomyces israelii
  2. bacterial conjunctivitis
  3. blepharitis
  4. blepharoconjunctivitis
  5. burns
  6. Clostridium difficile
  7. Corynebacterium sp.
  8. Fusobacterium sp.
  9. keratitis
  10. keratoconjunctivitis
  11. Neisseria gonorrhoeae
  12. Neisseria meningitidis
  13. ophthalmic infection
  14. pleural empyema
  15. pneumonia
  16. skin abrasion
  17. skin and skin structure infections
  18. Staphylococcus aureus (MSSA)
  19. Streptococcus sp.
  20. Treponema pallidum
  21. Treponema vincenti
  22. vancomycin-resistant enterococci (VRE)

Side Effects

  1. anaphylactic shock
  2. anaphylactoid reactions
  3. azotemia
  4. blurred vision
  5. cylindruria
  6. eosinophilia
  7. fever
  8. hematuria
  9. injection site reaction
  10. myasthenia
  11. nausea
  12. nephrotoxicity
  13. oliguria
  14. proteinuria
  15. pruritus
  16. rash
  17. renal failure (unspecified)
  18. renal tubular necrosis
  19. respiratory arrest
  20. respiratory depression
  21. superinfection
  22. urticaria
  23. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • children
  • colitis
  • contact lenses
  • diarrhea
  • fungal infection
  • GI disease
  • infants
  • inflammatory bowel disease
  • myasthenia gravis
  • neomycin hypersensitivity
  • nephrotoxicity
  • neuromuscular disease
  • ocular exposure
  • oliguria
  • pregnancy
  • pseudomembranous colitis
  • pulmonary disease
  • renal failure
  • renal impairment
  • surgery
  • ulcerative colitis

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Amikacin
  • Aminosalicylate sodium, Aminosalicylic acid
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Baclofen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bumetanide
  • Capreomycin
  • Capsaicin; Metaxalone
  • Carisoprodol
  • Chlorzoxazone
  • Choline Salicylate; Magnesium Salicylate
  • Cidofovir
  • Cisplatin
  • Colistimethate, Colistin, Polymyxin E
  • Cyclobenzaprine
  • Cyclosporine
  • Dantrolene
  • Diazepam
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Ethacrynic Acid
  • Foscarnet
  • Furosemide
  • Gallium Ga 68 Dotatate
  • Ganciclovir
  • General anesthetics
  • Gentamicin
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Immune Globulin IV, IVIG, IGIV
  • Inotersen
  • Kanamycin
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Loop diuretics
  • Magnesium Salicylate
  • Mannitol
  • Metaxalone
  • Methohexital
  • Neomycin
  • Neuromuscular blockers
  • Nonsteroidal antiinflammatory drugs
  • OnabotulinumtoxinA
  • Oral Contraceptives
  • Orphenadrine
  • Paromomycin
  • Pentamidine
  • Polymyxin B
  • Polymyxins
  • Pyridostigmine
  • RimabotulinumtoxinB
  • Salicylates
  • Salsalate
  • Skeletal Muscle Relaxants
  • Streptomycin
  • Tacrolimus
  • Telavancin
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Thiopental
  • Tizanidine
  • Tobramycin
  • Torsemide
  • Valganciclovir
  • Vancomycin
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