Bacillus Calmette Guerin Vaccine BCG

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Bacillus Calmette Guerin Vaccine BCG Brand Name– BCG VACCINE

What is Bacillus Calmette Guerin Vaccine BCG

Bacillus Calmette Guerin Vaccine BCG is a live, attenuated strain of Mycobacterium bovis used as a vaccine for tuberculosis prevention.

The vaccine is not for the treatment of active tuberculosis. In developing countries where tuberculosis is epidemic and short-term prophylaxis with anti-tuberculosis agents is not possible,

BCG vaccination is routinely used to attempt to control tuberculosis. The primary prevention and control strategy in the U.S. is transmission risk minimization by early identification and treatment of patients with active disease.

The use of BCG vaccination in the U.S. should be limited to select individuals in whom other tuberculosis control measures cannot be used or have been ineffective.

Vaccination of health care workers is not a primary strategy because the efficacy of the vaccine in adults is uncertain, and other persons in the health care facility such as visitors and patients are unprotected. Health care providers are encouraged to discuss the need for vaccination of their patients with either local tuberculosis control program personnel or Centers for Disease Control personnel (404—639—8120).

The BCG vaccine has been used since 1921 in the U.S.; the only FDA approved product for tuberculosis prophylaxis is BCG Vaccine, USP (TICE® BCG strain). In 1998, the FDA required Organon to label the indications for TICE® BCG strain separately as two products, BCG Vaccine, USP, and BCG Live (intravesical).

Indications & Dosage

  • tuberculosis prophylaxis

For tuberculosis prophylaxis in patients who have not been previously infected with Mycobacterium tuberculosis but who are at high risk of exposure

Side Effects

  1. anorexia
  2. arthralgia
  3. erythema
  4. erythema multiforme
  5. erythema nodosum
  6. fever
  7. infection
  8. injection site reaction
  9. lupus-like symptoms
  10. lymphadenopathy
  11. myalgia
  12. rash
  13. skin ulcer
  14. urticaria

Monitoring Parameters

  • LFTs

Contraindications

  • accidental exposure
  • acquired immunodeficiency syndrome (AIDS)
  • bone marrow suppression
  • breast-feeding
  • chemotherapy
  • corticosteroid therapy
  • diabetes mellitus
  • geriatric
  • history of angioedema
  • human immunodeficiency virus (HIV) infection
  • immunosuppression
  • infection
  • intravenous administration
  • mycobacterial infection
  • polysorbate 80 hypersensitivity
  • pregnancy
  • radiation therapy
  • renal failure
  • severe combined immunodeficiency (SCID)
  • subcutaneous administration
  • tuberculosis

Interactions

  • Abatacept
  • Adalimumab
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Alkylating agents
  • Alpha interferons
  • Altretamine
  • Amikacin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Anakinra
  • Anthracyclines
  • Antimetabolites
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Axicabtagene Ciloleucel
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Belatacept
  • Belimumab
  • Bexarotene
  • Blinatumomab
  • Brodalumab
  • Busulfan
  • Canakinumab
  • Capreomycin
  • Carmustine, BCNU
  • Certolizumab pegol
  • Chlorambucil
  • Ciprofloxacin
  • Cisplatin
  • Clarithromycin
  • Clofarabine
  • Clozapine
  • Cortisone
  • Cyclophosphamide
  • Cyclosporine
  • Cytarabine, ARA-C
  • Dacarbazine, DTIC
  • Daclizumab
  • Deflazacort
  • Dexamethasone
  • Digoxin
  • Docetaxel
  • Doxycycline
  • Dupilumab
  • Efalizumab
  • Emapalumab
  • Estramustine
  • Etanercept
  • Ethambutol
  • Ethionamide
  • Everolimus
  • Fingolimod
  • Floxuridine
  • Fludrocortisone
  • Fluorouracil, 5-FU
  • Folate analogs
  • Gentamicin
  • Golimumab
  • Guselkumab
  • Hydrocortisone
  • Hydroxocobalamin
  • Ifosfamide
  • Imatinib
  • Infliximab
  • Interferon Gamma-1b
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ixabepilone
  • Ixekizumab
  • Kanamycin
  • Leflunomide
  • Lenalidomide
  • Lomustine, CCNU
  • Mechlorethamine, Nitrogen Mustard
  • Melphalan
  • Methylprednisolone
  • Mitoxantrone
  • Muromonab-CD3
  • Mycophenolate
  • Natalizumab
  • Nelarabine
  • Nilotinib
  • Obinutuzumab
  • Ocrelizumab
  • Ofatumumab
  • Ofloxacin
  • Omeprazole; Amoxicillin; Rifabutin
  • Paclitaxel
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Purine analogs
  • Rifabutin
  • Rifampin
  • Rilonacept
  • Risankizumab
  • Rituximab
  • Rituximab; Hyaluronidase
  • Sarilumab
  • Secukinumab
  • Siltuximab
  • Siponimod
  • Sirolimus
  • Streptomycin
  • Streptozocin
  • Tacrolimus
  • Temozolomide
  • Temsirolimus
  • Teriflunomide
  • Thiotepa
  • Tildrakizumab
  • Tisagenlecleucel
  • Tocilizumab
  • Tofacitinib
  • Tositumomab
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Ustekinumab
  • Vedolizumab
  • Venetoclax
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine

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