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What is Tenofovir Alafenamide
Tenofovir alafenamide is a hepatitis B virus (HBV) nucleoside analog reverse transcriptase inhibitor.
It is indicated for the treatment of chronic HBV infection in adults with compensated liver disease.
Similar to tenofovir disoproxil fumarate, the FDA-approved package labeling for tenofovir alafenamide contains a Black Box Warning regarding the potential for acute exacerbations of hepatitis B in patients following treatment discontinuation.
Avoid the use of tenofovir alafenamide in patients with an estimated creatinine clearance of less than 15 mL/min who are NOT receiving chronic hemodialysis.
For patients on hemodialysis, no dosage adjustment is needed and the drug should be administered after completion of the hemodialysis treatment on dialysis days.
Brand Name
Vemlidy
Indications
- hepatitis B infection
- hepatitis B virus
Side Effects
- abdominal pain
- angioedema
- arthralgia
- back pain
- bone fractures
- bone pain
- cough
- diarrhea
- dyspepsia
- elevated hepatic enzymes
- Fanconi syndrome
- fatigue
- flatulence
- glycosuria
- headache
- hepatic decompensation
- hepatic failure
- hepatitis B exacerbation
- hepatomegaly
- hyperamylasemia
- hypercholesterolemia
- hypophosphatemia
- lactic acidosis
- myalgia
- nausea
- osteopenia
- osteoporosis
- pancreatitis
- rash
- renal failure (unspecified)
- steatosis
- urticaria
- vomiting
- weakness
- weight gain
Monitoring Parameters
- hepatitis B serology
- LFTs
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine
- serum lipid profile
- serum phosphate
- urinalysis
Contraindications
- alcoholism
- Black patients
- breast-feeding
- children
- females
- hepatic disease
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatomegaly
- hepatotoxicity or lactic acidosis
- Hispanic patients
- hypercholesterolemia
- hyperlipidemia
- hypertriglyceridemia
- hypophosphatemia
- infants
- neonates
- obesity
- osteomalacia
- osteoporosis
- pancreatitis
- pregnancy
- renal disease
- renal failure
Interactions
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adefovir
- Alogliptin; Metformin
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Bacitracin
- Barium Sulfate
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Brigatinib
- Cabozantinib
- Canagliflozin; Metformin
- Capmatinib
- Carbamazepine
- Carboplatin
- Carvedilol
- Celecoxib
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisplatin
- Clarithromycin
- Cobicistat
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Daclatasvir
- Dapagliflozin; Metformin
- Darolutamide
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole; Naproxen
- Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestimate
- Etodolac
- Famotidine; Ibuprofen
- Felodipine
- Fenoprofen
- Flibanserin
- Flurbiprofen
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Gadobutrol
- Gadoversetamide
- Ganciclovir
- Gentamicin
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ivacaftor
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Magnesium Salicylate
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Mifepristone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nitisinone
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Obeticholic Acid
- Omeprazole; Amoxicillin; Rifabutin
- Orlistat
- Osimertinib
- Oxaliplatin
- Oxaprozin
- Oxcarbazepine
- Pamidronate
- Paromomycin
- Phenobarbital
- Phenytoin
- Pirfenidone
- Piroxicam
- Plazomicin
- Polymyxin B
- Polymyxins
- Posaconazole
- Primidone
- Probenecid
- Ranolazine
- Regorafenib
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rivaroxaban
- Rofecoxib
- Rolapitant
- Salicylates
- Salsalate
- Sapropterin
- Simeprevir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sulindac
- Tacrolimus
- Tafamidis
- Tedizolid
- Telithromycin
- Temsirolimus
- Testosterone
- Tezacaftor; Ivacaftor
- Ticagrelor
- Tipranavir
- Tobramycin
- Tolmetin
- Tolvaptan
- Trandolapril; Verapamil
- Trospium
- Tucatinib
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Vemurafenib
- Verapamil
- Zoledronic Acid
- Zonisamide