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Aspirin Butalbital Caffeine Codeine Brand Names- Ascomp | Fiorinal with Codeine
What is Aspirin Butalbital Caffeine Codeine
Aspirin butalbital caffeine codeine are used together in an oral preparation to treat occasional tension headaches, migraines, and mild to moderate pain, especially when antianxiety or relaxant effects are needed.
Treatment of multiple recurrent headaches with this combination has not been well studied; long-term use is not recommended.
According to published guidelines for the acute management of migraine, the use of butalbital-containing analgesics should be limited and carefully monitored due to concerns of overuse, medication-overuse headache, and withdrawal.
Aspirin is a salicylate analgesic with similar analgesic potency to NSAIDs. Butalbital is a short-to-intermediate acting barbiturate that is used in this combination for its sedative and relaxant effects.
Caffeine is found in many analgesic formulations and may be beneficial in some vascular headaches such as tension and cluster headaches and migraines. Codeine is an oral semisynthetic opiate agonist derived from the opioid alkaloid, thebaine.
Codeine is a prodrug that is hepatically metabolized to morphine. Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.
Codeine use is contraindicated in pediatric patients younger than 12 years.
The American Academy of Pediatrics (AAP) recommends against the use of codeine and codeine-containing products in all pediatric patients for any indication.
Indications
- headache
- migraine
- mild pain
- moderate pain
For the treatment of occasional tension headache, occasional migraine† or co-existing migraine† and tension-type headaches
Side Effects
- abdominal pain
- adrenocortical insufficiency
- agitation
- amenorrhea
- anaphylactic shock
- anemia
- anorexia
- anxiety
- appetite stimulation
- chest pain (unspecified)
- constipation
- depression
- diarrhea
- diuresis
- dizziness
- drowsiness
- dysuria
- edema
- epistaxis
- erythema
- erythema multiforme
- esophagitis
- exfoliative dermatitis
- fatigue
- fever
- flushing
- gonadal suppression
- hallucinations
- headache
- hemolytic anemia
- hepatitis
- hiccups
- hyperactivity
- hyperglycemia
- hyperhidrosis
- hypersalivation
- hyponatremia
- hypotension
- impotence (erectile dysfunction)
- infertility
- insomnia
- lethargy
- libido decrease
- miosis
- musculoskeletal pain
- nasal congestion
- nausea
- neonatal opioid withdrawal syndrome
- nephrotoxicity
- palpitations
- peptic ulcer
- physiological dependence
- prolonged bleeding time
- pruritus
- psychological dependence
- psychosis
- pyrosis (heartburn)
- rash
- respiratory arrest
- respiratory depression
- Reye’s syndrome
- serotonin syndrome
- SIADH
- sinus tachycardia
- syncope
- tinnitus
- toxic epidermal necrolysis
- urticaria
- vertigo
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acute bronchospasm
- acute myocardial infarction
- adenoidectomy
- adrenal insufficiency
- agranulocytosis
- alcoholism
- anemia
- angina
- angioedema
- anticoagulant therapy
- ascites
- Asian patients
- asthma
- barbiturate hypersensitivity
- Black patients
- bladder obstruction
- bone marrow suppression
- breast-feeding
- carbamazepine hypersensitivity
- cardiac arrhythmias
- cardiac disease
- Caucasian patients
- children
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coagulopathy
- constipation
- dehydration
- depression
- diabetes mellitus
- driving or operating machinery
- endocarditis
- esophagitis
- ethanol ingestion
- ethanol intoxication
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- gout
- head trauma
- heart failure
- hematological disease
- hemolytic anemia
- hemophilia
- hepatic disease
- hepatic encephalopathy
- hepatitis
- Hispanic patients
- hydantoin hypersensitivity
- hypertension
- hypoprothrombinemia
- hypotension
- hypothyroidism
- hypovolemia
- ileus
- immunosuppression
- increased intracranial pressure
- infants
- infection
- inflammatory bowel disease
- influenza
- intracranial bleeding
- intramuscular injections
- labor
- MAOI therapy
- mental status changes
- myxedema
- nasal polyps
- neonatal opioid withdrawal syndrome
- neonates
- neuromuscular disease
- neutropenia
- NSAID hypersensitivity
- obesity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- osteomalacia
- osteoporosis
- pain
- peptic ulcer disease
- pericarditis
- porphyria
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- respiratory depression
- respiratory infection
- Reye’s syndrome
- salicylate hypersensitivity
- seizure disorder
- seizures
- sleep apnea
- sodium restriction
- status asthmaticus
- status epilepticus
- substance abuse
- suicidal ideation
- surgery
- systemic lupus erythematosus (SLE)
- tartrazine dye hypersensitivity
- thrombocytopenia
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- thyroid disease
- tobacco smoking
- tonsillectomy
- urethral stricture
- urinary retention
- urticaria
- varicella
- viral infection
- vitamin K deficiency
- von Willebrand’s disease
Interactions
- Abciximab
- Abemaciclib
- Abiraterone
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Acidifying Agents
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Adenosine
- Ado-Trastuzumab emtansine
- Albuterol
- Albuterol; Ipratropium
- Aldesleukin, IL-2
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Almotriptan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Altretamine
- Alvimopan
- Amantadine
- Amide local anesthetics
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Ampicillin
- Ampicillin; Sulbactam
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- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Ascorbic Acid, Vitamin C
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol; Chlorthalidone
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Avatrombopag
- Axitinib
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Bacitracin
- Baclofen
- Barbiturates
- Bedaquiline
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendamustine
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzonatate
- Benzphetamine
- Benztropine
- Beta-agonists
- Beta-blockers
- Bethanechol
- Betrixaban
- Bexarotene
- Bicalutamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bisphosphonates
- Bortezomib
- Bosentan
- Brexpiprazole
- Brigatinib
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brivaracetam
- Bromocriptine
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Calcifediol
- Calcitriol
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capmatinib
- Capreomycin
- Capsaicin; Metaxalone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbenicillin
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cardiac glycosides
- Cariprazine
- Carisoprodol
- Cefixime
- Cefotetan
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine
- Cetirizine; Pseudoephedrine
- Cevimeline
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlorambucil
- Chloramphenicol
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cilostazol
- Cimetidine
- Cinacalcet
- Ciprofloxacin
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Citric Acid; Sodium Citrate
- Clarithromycin
- Clemastine
- Clobazam
- Clomipramine
- Clonazepam
- Clonidine
- Clopidogrel
- Clorazepate
- Clozapine
- Cobicistat
- Cobimetinib
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Collagenase
- COMT inhibitors
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Corticosteroids
- Crizotinib
- Crofelemer
- Cyclizine
- Cyclobenzaprine
- Cyclophosphamide
- Cyclosporine
- Cyproheptadine
- Dabigatran
- Dabrafenib
- Dacomitinib
- Dalfopristin; Quinupristin
- Dalteparin
- Danazol
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Daratumumab; Hyaluronidase
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Defibrotide
- Deflazacort
- Delavirdine
- Desflurane
- Desipramine
- Desloratadine; Pseudoephedrine
- Desmopressin
- Desvenlafaxine
- Deutetrabenazine
- Dexamethasone
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dexpanthenol
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dicloxacillin
- Dienogest; Estradiol valerate
- Diethylpropion
- Diethylstilbestrol, DES
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Disopyramide
- Disulfiram
- Dobutamine
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Dopamine
- Doravirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Doxepin
- Doxercalciferol
- Doxorubicin
- Doxycycline
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Duloxetine
- Dyphylline
- Dyphylline; Guaifenesin
- Echinacea
- Edoxaban
- Efalizumab
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Eliglustat
- Eltrombopag
- Eluxadoline
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encorafenib
- Enflurane
- Enoxaparin
- Entacapone
- Entrectinib
- Enzalutamide
- Ephedrine
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Erdafitinib
- Erlotinib
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Eslicarbazepine
- Esomeprazole
- Esomeprazole; Naproxen
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Estropipate
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
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- Fedratinib
- Felodipine
- Fenoprofen
- Fentanyl
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
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- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- food
- Formoterol
- Formoterol; Mometasone
- Fosamprenavir
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
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- Fostamatinib
- Frovatriptan
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- Galantamine
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- Garlic, Allium sativum
- General anesthetics
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- Glimepiride; Pioglitazone
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- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- Granisetron
- grapefruit juice
- Green Tea
- Griseofulvin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Hemin
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
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- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
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- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
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- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
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- Iloperidone
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- Isoflurane
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- Ketamine
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- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Lincosamides
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lofexidine
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorazepam
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Low Molecular Weight Heparins
- Loxapine
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Lurbinectedin
- Macimorelin
- Magnesium Salicylate
- Magnesium Salts
- Mannitol
- Maprotiline
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Mebendazole
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Melatonin
- Meloxicam
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mestranol; Norethindrone
- Metaproterenol
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methamphetamine
- Methazolamide
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methotrexate
- Methscopolamine
- Methsuximide
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Methylprednisolone
- Methylsulfonylmethane, MSM
- Metoclopramide
- Metolazone
- Metronidazole
- Metyrapone
- Metyrosine
- Mexiletine
- Midazolam
- Midodrine
- Mifepristone
- Milnacipran
- Minocycline
- Mirabegron
- Mirtazapine
- Mitotane
- Modafinil
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Muromonab-CD3
- Mycophenolate
- Nabilone
- Nabumetone
- Nafcillin
- Nalbuphine
- Naloxone
- Naltrexone
- Nanoparticle Albumin-Bound Paclitaxel
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nateglinide
- Nefazodone
- Nelfinavir
- Neratinib
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nintedanib
- Nisoldipine
- Nitazoxanide
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Nortriptyline
- Obeticholic Acid
- Octreotide
- Olanzapine
- Olaparib
- Olodaterol
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Oxacillin
- Oxaprozin
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paclitaxel
- Palbociclib
- Paliperidone
- Palonosetron
- Panobinostat
- Papaverine
- Paroxetine
- Peginterferon Alfa-2b
- Pegvisomant
- Pemigatinib
- Pemoline
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pentosan
- Pentoxifylline
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Phosphorated Carbohydrate Solution
- Phosphorus
- Photosensitizing agents (topical)
- Pimavanserin
- Pimozide
- Pioglitazone
- Piperacillin
- Piperacillin; Tazobactam
- Pirbuterol
- Piroxicam
- Pneumococcal Vaccine, Polyvalent
- Polymyxins
- Pomalidomide
- Posaconazole
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Potassium-sparing diuretics
- Pralidoxime
- Pramipexole
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prasugrel
- Prednisolone
- Prednisone
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procarbazine
- Prochlorperazine
- Progestins
- Promethazine
- Propafenone
- Propofol
- Protriptyline
- Pseudoephedrine
- Psyllium
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Rabeprazole
- Racepinephrine
- Ramelteon
- Ramipril
- Ranolazine
- Rasagiline
- Red Yeast Rice
- Regadenoson
- Remifentanil
- Repaglinide
- Reserpine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rilpivirine
- Riluzole
- Rimegepant
- Risperidone
- Ritodrine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Rizatriptan
- Roflumilast
- Rolapitant
- Romidepsin
- Ropinirole
- Ropivacaine
- Rosiglitazone
- Rotigotine
- Rucaparib
- Safinamide
- Salicylates
- Salicylic Acid
- Salmeterol
- Salsalate
- Saquinavir
- Saxagliptin
- Scopolamine
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Selumetinib
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sitagliptin
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Lactate
- Sodium Oxybate
- Sodium Thiosulfate; Salicylic Acid
- Solifenacin
- Solriamfetol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sufentanil
- Sulfinpyrazone
- Sulfonamides
- Sulfonylureas
- Sulindac
- Sumatriptan
- Sunitinib
- Suvorexant
- Tacrolimus
- Tapentadol
- Tasimelteon
- Tazemetostat
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Terbutaline
- Teriflunomide
- Tetrabenazine
- Tetracaine
- Thalidomide
- Theophylline, Aminophylline
- Thiabendazole
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thrombin Inhibitors
- Thrombolytic Agents
- Thyroid hormones
- Ticagrelor
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Ticlopidine
- Tinzaparin
- Tiotropium; Olodaterol
- Tipranavir
- Tirofiban
- Tizanidine
- tobacco
- Tolazamide
- Tolbutamide
- Tolcapone
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Triamcinolone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trimetrexate
- Trimipramine
- Triprolidine
- Tromethamine
- Trospium
- Tucatinib
- Ubrogepant
- Ulipristal
- Umeclidinium; Vilanterol
- Valbenazine
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Vilazodone
- Vincristine
- Vincristine Liposomal
- Vorapaxar
- Voriconazole
- Vortioxetine
- Voxelotor
- Warfarin
- Yohimbine
- Zafirlukast
- Zaleplon
- Zanubrutinib
- Ziconotide
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zolpidem
- Zonisamide
