Aspirin Caffeine Dihydrocodeine

Aspirin Caffeine Dihydrocodeine Brand Name– Synalgos-DC

What is Aspirin Caffeine Dihydrocodeine

Aspirin caffeine dihydrocodeine are used together in an oral preparation to treat moderate to severe pain.

Aspirin is a non-narcotic analgesic for pain and headache relief. Caffeine is found in many analgesic formulations and may be beneficial in some vascular headaches.

Dihydrocodeine is an opiate analgesic that is structurally related to morphine.

The combination of aspirin and dihydrocodeine produces a greater analgesic effect than that produced by aspirin alone or by higher doses of opiates.

Also, the combination might cause fewer adverse reactions than equianalgesic doses of either agent alone.

The FDA approved the aspirin caffeine dihydrocodeine combination in July 1958.

Indications

  1. arthralgia
  2. bone pain
  3. dental pain
  4. dysmenorrhea
  5. headache
  6. moderate pain
  7. myalgia
  8. severe pain

For the treatment of moderate pain to severe pain (i.e. headache, myalgia, back pain, bone pain, dental pain, dysmenorrhea, or arthralgia)

Side Effects

  1. abdominal pain
  2. acneiform rash
  3. acute generalized exanthematous pustulosis (AGEP)
  4. adrenocortical insufficiency
  5. agitation
  6. agranulocytosis
  7. amenorrhea
  8. anaphylactoid reactions
  9. angioedema
  10. anxiety
  11. aplastic anemia
  12. azotemia
  13. bronchospasm
  14. cerebral edema
  15. coma
  16. confusion
  17. constipation
  18. dehydration
  19. delirium
  20. diaphoresis
  21. diarrhea
  22. disseminated intravascular coagulation (DIC)
  23. dizziness
  24. drowsiness
  25. dyspepsia
  26. dysphagia
  27. elevated hepatic enzymes
  28. epistaxis
  29. erythema nodosum
  30. esophageal stricture
  31. esophageal ulceration
  32. esophagitis
  33. excitability
  34. fatigue
  35. gastritis
  36. GI bleeding
  37. GI perforation
  38. gonadal suppression
  39. hallucinations
  40. headache
  41. hearing loss
  42. hematoma
  43. hemolysis
  44. hemolytic anemia
  45. hepatic encephalopathy
  46. hepatic necrosis
  47. hyperbilirubinemia
  48. hypercalciuria
  49. hyperglycemia
  50. hypernatremia
  51. hyperuricemia
  52. hyperventilation
  53. hypoglycemia
  54. hypokalemia
  55. hyponatremia
  56. impotence (erectile dysfunction)
  57. infertility
  58. insomnia
  59. interstitial nephritis
  60. irritability
  61. jaundice
  62. laryngeal edema
  63. lethargy
  64. leukocytosis
  65. leukopenia
  66. libido decrease
  67. maculopapular rash
  68. metabolic acidosis
  69. miosis
  70. nausea
  71. neonatal opioid withdrawal syndrome
  72. odynophagia
  73. orthostatic hypotension
  74. palpitations
  75. pancytopenia
  76. physiological dependence
  77. platelet dysfunction
  78. polyuria
  79. prolonged bleeding time
  80. proteinuria
  81. pruritus
  82. psychological dependence
  83. pulmonary edema
  84. purpura
  85. pyrosis (heartburn)
  86. renal failure (unspecified)
  87. renal papillary necrosis
  88. renal tubular necrosis
  89. respiratory arrest
  90. respiratory depression
  91. Reye’s syndrome
  92. rhinitis
  93. seizures
  94. serotonin syndrome
  95. SIADH
  96. sinus tachycardia
  97. Stevens-Johnson syndrome
  98. thrombocytopenia
  99. tinnitus
  100. tolerance
  101. toxic epidermal necrolysis
  102. tremor
  103. urticaria
  104. visual impairment
  105. vomiting
  106. wheezing
  107. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • accidental exposure
  • acid/base imbalance
  • acute bronchospasm
  • acute myocardial infarction
  • adenoidectomy
  • adrenal insufficiency
  • agranulocytosis
  • alcoholism
  • anemia
  • angina
  • angioedema
  • anticoagulant therapy
  • ascites
  • Asian patients
  • asthma
  • biliary cirrhosis
  • biliary obstruction
  • biliary tract disease
  • Black patients
  • bladder obstruction
  • bleeding
  • bone marrow suppression
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • Caucasian patients
  • children
  • chronic obstructive pulmonary disease (COPD)
  • CNS depression
  • coadministration with other CNS depressants
  • coagulopathy
  • coma
  • constipation
  • cor pulmonale
  • dehydration
  • depression
  • diabetes mellitus
  • diarrhea
  • driving or operating machinery
  • esophagitis
  • ethanol intoxication
  • G6PD deficiency
  • gastritis
  • geriatric
  • GI bleeding
  • GI disease
  • GI obstruction
  • gout
  • head trauma
  • heart failure
  • hemophilia
  • hepatic disease
  • hepatitis
  • Hispanic patients
  • hypertension
  • hyperuricemia
  • hypoprothrombinemia
  • hypotension
  • hypothyroidism
  • hypovolemia
  • hypoxemia
  • ileus
  • immunosuppression
  • increased intracranial pressure
  • infants
  • inflammatory bowel disease
  • influenza
  • intracranial mass
  • intramuscular injections
  • labor
  • MAOI therapy
  • mental status changes
  • metabolic acidosis
  • metabolic alkalosis
  • myxedema
  • nasal polyps
  • neonatal opioid withdrawal syndrome
  • neonates
  • neuromuscular disease
  • neutropenia
  • NSAID hypersensitivity
  • obesity
  • obstetric delivery
  • oliguria
  • opiate agonist hypersensitivity
  • opioid-naive patients
  • pancreatitis
  • peptic ulcer disease
  • potential for overdose or poisoning
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis
  • respiratory alkalosis
  • respiratory depression
  • respiratory infection
  • salicylate hypersensitivity
  • seizure disorder
  • seizures
  • shock
  • sleep apnea
  • status asthmaticus
  • substance abuse
  • suicidal ideation
  • surgery
  • systemic lupus erythematosus (SLE)
  • thrombocytopenia
  • thrombolytic therapy
  • thrombotic thrombocytopenic purpura (TTP)
  • tobacco smoking
  • tonsillectomy
  • ulcerative colitis
  • urethral stricture
  • urinary retention
  • urinary tract obstruction
  • urticaria
  • varicella
  • viral infection
  • vitamin K deficiency
  • von Willebrand’s disease

Drug Interactions

  • Abciximab
  • Abiraterone
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Acidifying Agents
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Adenosine
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  • Aldesleukin, IL-2
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  • Aliskiren; Hydrochlorothiazide, HCTZ
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  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
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  • Amoxicillin; Clavulanic Acid
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  • Amphetamine; Dextroamphetamine Salts
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  • Ascorbic Acid, Vitamin C
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Oxycodone
  • Atazanavir
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  • Atropine
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  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Bacitracin
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  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
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  • Beta-agonists
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  • Bethanechol
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  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
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  • Bupropion
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  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
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  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capmatinib
  • Capreomycin
  • Capsaicin; Metaxalone
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbenicillin
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Cefixime
  • Cefotetan
  • Celecoxib
  • Cenobamate
  • Ceritinib
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chloramphenicol
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroprocaine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cidofovir
  • Cilostazol
  • Cimetidine
  • Cinacalcet
  • Ciprofloxacin
  • Citalopram
  • Citric Acid; Potassium Citrate
  • Citric Acid; Potassium Citrate; Sodium Citrate
  • Citric Acid; Sodium Citrate
  • Clarithromycin
  • Clemastine
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonidine
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine; Probenecid
  • Colistimethate, Colistin, Polymyxin E
  • Collagenase
  • COMT inhibitors
  • Conivaptan
  • Corticosteroids
  • Crizotinib
  • Crofelemer
  • Cyclizine
  • Cyclobenzaprine
  • Cyclosporine
  • Cyproheptadine
  • Dabigatran
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  • Dacomitinib
  • Dalfopristin; Quinupristin
  • Dalteparin
  • Danazol
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Daratumumab; Hyaluronidase
  • Darifenacin
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  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Defibrotide
  • Delavirdine
  • Desflurane
  • Desipramine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dexpanthenol
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dichlorphenamide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dicloxacillin
  • Dicyclomine
  • Diethylpropion
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Disulfiram
  • Dobutamine
  • Dolasetron
  • Dopamine
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  • Doxylamine; Pyridoxine
  • Dronabinol
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  • Echinacea
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  • Elagolix
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  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encorafenib
  • Enflurane
  • Enoxaparin
  • Enzalutamide
  • Ephedrine
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eptifibatide
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Eslicarbazepine
  • Esomeprazole; Naproxen
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
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  • Ethinyl Estradiol; Desogestrel
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  • Ethinyl Estradiol; Etonogestrel
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  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
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  • Ethotoin
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  • Granisetron
  • grapefruit juice
  • Green Tea
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  • Guaifenesin; Hydrocodone; Pseudoephedrine
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  • Hydrocodone
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  • Indinavir
  • Indomethacin
  • Inotersen
  • Insulins
  • Intravenous Lipid Emulsions
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Isavuconazonium
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Istradefylline
  • Itraconazole
  • Ivacaftor
  • Ketamine
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole; Naproxen
  • Lapatinib
  • Larotrectinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lesinurad
  • Lesinurad; Allopurinol
  • Letermovir
  • Levalbuterol
  • Levobupivacaine
  • Levocetirizine
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linagliptin
  • Linagliptin; Metformin
  • Lincosamides
  • Linezolid
  • Lisdexamfetamine
  • Lisinopril
  • Lithium
  • Lofexidine
  • Loop diuretics
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Lorcaserin
  • Lorlatinib
  • Low Molecular Weight Heparins
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Salts
  • Mannitol
  • Maprotiline
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meglitinides
  • Melatonin
  • Meloxicam
  • Mepenzolate
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Meprobamate
  • Mestranol; Norethindrone
  • Metaproterenol
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methazolamide
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methohexital
  • Methotrexate
  • Methscopolamine
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylphenidate
  • Methylsulfonylmethane, MSM
  • Metoclopramide
  • Metolazone
  • Metyrapone
  • Metyrosine
  • Mexiletine
  • Midazolam
  • Midodrine
  • Mifepristone
  • Minocycline
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Modafinil
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Muromonab-CD3
  • Mycophenolate
  • Nabilone
  • Nabumetone
  • Nafcillin
  • Nalbuphine
  • Naloxone
  • Naltrexone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nateglinide
  • Nefazodone
  • Nelfinavir
  • Nesiritide, BNP
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Nicardipine
  • Nilotinib
  • Nitazoxanide
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Nortriptyline
  • Obeticholic Acid
  • Octreotide
  • Olanzapine
  • Olodaterol
  • Omacetaxine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Oxacillin
  • Oxaprozin
  • Oxazepam
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Palbociclib
  • Paliperidone
  • Palonosetron
  • Panobinostat
  • Papaverine
  • Paroxetine
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pegvisomant
  • Pemoline
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Pentosan
  • Pentoxifylline
  • Perampanel
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Photosensitizing agents (topical)
  • Pimozide
  • Pioglitazone
  • Piperacillin
  • Piperacillin; Tazobactam
  • Pirbuterol
  • Piroxicam
  • Pneumococcal Vaccine, Polyvalent
  • Polymyxins
  • Posaconazole
  • Potassium Bicarbonate
  • Potassium Chloride
  • Potassium Citrate
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Pramipexole
  • Pramlintide
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Prasugrel
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Probenecid
  • Procaine
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propofol
  • Protriptyline
  • Pseudoephedrine
  • Psyllium
  • Quazepam
  • Quetiapine
  • Quinapril
  • Quinidine
  • Quinine
  • Racepinephrine
  • Ramelteon
  • Ramipril
  • Ranolazine
  • Rasagiline
  • Regadenoson
  • Repaglinide
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rifaximin
  • Risperidone
  • Ritodrine
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivaroxaban
  • Rizatriptan
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rosiglitazone
  • Rotigotine
  • Rucaparib
  • Safinamide
  • Salicylic Acid
  • Salmeterol
  • Saquinavir
  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selective serotonin reuptake inhibitors
  • Selegiline
  • Selpercatinib
  • Serotonin norepinephrine reuptake inhibitors
  • Serotonin-Receptor Agonists
  • Serotonin-Receptor Antagonists
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sildenafil
  • Simvastatin; Sitagliptin
  • Sitagliptin
  • Skeletal Muscle Relaxants
  • Sodium Bicarbonate
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sodium Lactate
  • Sodium Oxybate
  • Sodium Thiosulfate; Salicylic Acid
  • Solifenacin
  • Solriamfetol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Streptogramins
  • Sulfinpyrazone
  • Sulfonamides
  • Sulfonylureas
  • Sulindac
  • Sumatriptan
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Tasimelteon
  • Telavancin
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Terbinafine
  • Terbutaline
  • Teriflunomide
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiabendazole
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thrombin Inhibitors
  • Thrombolytic Agents
  • Ticagrelor
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Ticlopidine
  • Tinzaparin
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tirofiban
  • Tizanidine
  • tobacco
  • Tolazamide
  • Tolbutamide
  • Tolmetin
  • Tolterodine
  • Topiramate
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Tromethamine
  • Trospium
  • Tucatinib
  • Umeclidinium; Vilanterol
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vancomycin
  • Varicella-Zoster Virus Vaccine, Live
  • Venlafaxine
  • Verapamil
  • Verteporfin
  • Vigabatrin
  • Vilazodone
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Ziconotide
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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