Aspirin Caffeine Dihydrocodeine Brand Name– Synalgos-DC
What is Aspirin Caffeine Dihydrocodeine
Aspirin caffeine dihydrocodeine are used together in an oral preparation to treat moderate to severe pain.
Aspirin is a non-narcotic analgesic for pain and headache relief. Caffeine is found in many analgesic formulations and may be beneficial in some vascular headaches.
Dihydrocodeine is an opiate analgesic that is structurally related to morphine.
The combination of aspirin and dihydrocodeine produces a greater analgesic effect than that produced by aspirin alone or by higher doses of opiates.
Also, the combination might cause fewer adverse reactions than equianalgesic doses of either agent alone.
The FDA approved the aspirin caffeine dihydrocodeine combination in July 1958.
Indications
- arthralgia
- bone pain
- dental pain
- dysmenorrhea
- headache
- moderate pain
- myalgia
- severe pain
For the treatment of moderate pain to severe pain (i.e. headache, myalgia, back pain, bone pain, dental pain, dysmenorrhea, or arthralgia)
Side Effects
- abdominal pain
- acneiform rash
- acute generalized exanthematous pustulosis (AGEP)
- adrenocortical insufficiency
- agitation
- agranulocytosis
- amenorrhea
- anaphylactoid reactions
- angioedema
- anxiety
- aplastic anemia
- azotemia
- bronchospasm
- cerebral edema
- coma
- confusion
- constipation
- dehydration
- delirium
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dyspepsia
- dysphagia
- elevated hepatic enzymes
- epistaxis
- erythema nodosum
- esophageal stricture
- esophageal ulceration
- esophagitis
- excitability
- fatigue
- gastritis
- GI bleeding
- GI perforation
- gonadal suppression
- hallucinations
- headache
- hearing loss
- hematoma
- hemolysis
- hemolytic anemia
- hepatic encephalopathy
- hepatic necrosis
- hyperbilirubinemia
- hypercalciuria
- hyperglycemia
- hypernatremia
- hyperuricemia
- hyperventilation
- hypoglycemia
- hypokalemia
- hyponatremia
- impotence (erectile dysfunction)
- infertility
- insomnia
- interstitial nephritis
- irritability
- jaundice
- laryngeal edema
- lethargy
- leukocytosis
- leukopenia
- libido decrease
- maculopapular rash
- metabolic acidosis
- miosis
- nausea
- neonatal opioid withdrawal syndrome
- odynophagia
- orthostatic hypotension
- palpitations
- pancytopenia
- physiological dependence
- platelet dysfunction
- polyuria
- prolonged bleeding time
- proteinuria
- pruritus
- psychological dependence
- pulmonary edema
- purpura
- pyrosis (heartburn)
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- respiratory arrest
- respiratory depression
- Reye’s syndrome
- rhinitis
- seizures
- serotonin syndrome
- SIADH
- sinus tachycardia
- Stevens-Johnson syndrome
- thrombocytopenia
- tinnitus
- tolerance
- toxic epidermal necrolysis
- tremor
- urticaria
- visual impairment
- vomiting
- wheezing
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- accidental exposure
- acid/base imbalance
- acute bronchospasm
- acute myocardial infarction
- adenoidectomy
- adrenal insufficiency
- agranulocytosis
- alcoholism
- anemia
- angina
- angioedema
- anticoagulant therapy
- ascites
- Asian patients
- asthma
- biliary cirrhosis
- biliary obstruction
- biliary tract disease
- Black patients
- bladder obstruction
- bleeding
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- Caucasian patients
- children
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- coadministration with other CNS depressants
- coagulopathy
- coma
- constipation
- cor pulmonale
- dehydration
- depression
- diabetes mellitus
- diarrhea
- driving or operating machinery
- esophagitis
- ethanol intoxication
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- gout
- head trauma
- heart failure
- hemophilia
- hepatic disease
- hepatitis
- Hispanic patients
- hypertension
- hyperuricemia
- hypoprothrombinemia
- hypotension
- hypothyroidism
- hypovolemia
- hypoxemia
- ileus
- immunosuppression
- increased intracranial pressure
- infants
- inflammatory bowel disease
- influenza
- intracranial mass
- intramuscular injections
- labor
- MAOI therapy
- mental status changes
- metabolic acidosis
- metabolic alkalosis
- myxedema
- nasal polyps
- neonatal opioid withdrawal syndrome
- neonates
- neuromuscular disease
- neutropenia
- NSAID hypersensitivity
- obesity
- obstetric delivery
- oliguria
- opiate agonist hypersensitivity
- opioid-naive patients
- pancreatitis
- peptic ulcer disease
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- renal disease
- renal failure
- renal impairment
- respiratory acidosis
- respiratory alkalosis
- respiratory depression
- respiratory infection
- salicylate hypersensitivity
- seizure disorder
- seizures
- shock
- sleep apnea
- status asthmaticus
- substance abuse
- suicidal ideation
- surgery
- systemic lupus erythematosus (SLE)
- thrombocytopenia
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- tobacco smoking
- tonsillectomy
- ulcerative colitis
- urethral stricture
- urinary retention
- urinary tract obstruction
- urticaria
- varicella
- viral infection
- vitamin K deficiency
- von Willebrand’s disease
Drug Interactions
- Abciximab
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- Mirtazapine
- Mitotane
- Modafinil
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Muromonab-CD3
- Mycophenolate
- Nabilone
- Nabumetone
- Nafcillin
- Nalbuphine
- Naloxone
- Naltrexone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nateglinide
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicardipine
- Nilotinib
- Nitazoxanide
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Nortriptyline
- Obeticholic Acid
- Octreotide
- Olanzapine
- Olodaterol
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oritavancin
- Orphenadrine
- Osilodrostat
- Oxacillin
- Oxaprozin
- Oxazepam
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Palbociclib
- Paliperidone
- Palonosetron
- Panobinostat
- Papaverine
- Paroxetine
- Pazopanib
- Peginterferon Alfa-2b
- Pegvisomant
- Pemoline
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pentosan
- Pentoxifylline
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Phosphorated Carbohydrate Solution
- Phosphorus
- Photosensitizing agents (topical)
- Pimozide
- Pioglitazone
- Piperacillin
- Piperacillin; Tazobactam
- Pirbuterol
- Piroxicam
- Pneumococcal Vaccine, Polyvalent
- Polymyxins
- Posaconazole
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Pramipexole
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prasugrel
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procaine
- Procarbazine
- Prochlorperazine
- Promethazine
- Propafenone
- Propantheline
- Propofol
- Protriptyline
- Pseudoephedrine
- Psyllium
- Quazepam
- Quetiapine
- Quinapril
- Quinidine
- Quinine
- Racepinephrine
- Ramelteon
- Ramipril
- Ranolazine
- Rasagiline
- Regadenoson
- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifamycins
- Rifapentine
- Rifaximin
- Risperidone
- Ritodrine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Rizatriptan
- Rolapitant
- Ropinirole
- Ropivacaine
- Rosiglitazone
- Rotigotine
- Rucaparib
- Safinamide
- Salicylic Acid
- Salmeterol
- Saquinavir
- Saxagliptin
- Scopolamine
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Selpercatinib
- Serotonin norepinephrine reuptake inhibitors
- Serotonin-Receptor Agonists
- Serotonin-Receptor Antagonists
- Sertraline
- Sevoflurane
- Sibutramine
- Sildenafil
- Simvastatin; Sitagliptin
- Sitagliptin
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Lactate
- Sodium Oxybate
- Sodium Thiosulfate; Salicylic Acid
- Solifenacin
- Solriamfetol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptogramins
- Sulfinpyrazone
- Sulfonamides
- Sulfonylureas
- Sulindac
- Sumatriptan
- Suvorexant
- Tacrolimus
- Tapentadol
- Tasimelteon
- Telavancin
- Telithromycin
- Telotristat Ethyl
- Temazepam
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Terbutaline
- Teriflunomide
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Theophylline, Aminophylline
- Thiabendazole
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thioridazine
- Thiothixene
- Thrombin Inhibitors
- Thrombolytic Agents
- Ticagrelor
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Ticlopidine
- Tinzaparin
- Tiotropium; Olodaterol
- Tipranavir
- Tirofiban
- Tizanidine
- tobacco
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimipramine
- Triprolidine
- Tromethamine
- Trospium
- Tucatinib
- Umeclidinium; Vilanterol
- Valerian, Valeriana officinalis
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Venlafaxine
- Verapamil
- Verteporfin
- Vigabatrin
- Vilazodone
- Vorapaxar
- Voriconazole
- Vortioxetine
- Warfarin
- Yohimbine
- Zafirlukast
- Zaleplon
- Ziconotide
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zolpidem