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Acetaminophen Aspirin Caffeine Brand Names
Bayer Migraine Formula | Excedrin Extra Strength | Excedrin Extra Strength Express | Excedrin Menstrual Complete | Excedrin Migraine | Genaced | Goody’s Extra Strength | Goody’s Extra Strength (Cool Orange) | Goody’s Extra Strength Headache | Goody’s Extra Strength Headache Powder (Mixed Fruit Blast ) | Pain Reliever Plus | Pamprin | Vanquish
What is Acetaminophen Aspirin Caffeine
Acetaminophen Aspirin Caffeine is an oral combination preparation used for the temporary relief of pain of headache (including migraine), sinusitis (e.g., sinus congestion), common cold (e.g., nasal congestion), myalgia, dysmenorrhea, dental pain (e.g., toothache), and minor arthritis pain. Acetaminophen and aspirin are analgesics.
Caffeine is included in many nonprescription products to enhance analgesic efficacy. Although some data indicate that caffeine may increase bioavailability of certain analgesics, caffeine does not have intrinsic analgesic properties.
Excedrin(R) Extra Strength was the first OTC product to be FDA approved for the treatment of migraines. Excedrin(R) Migraine was marketed as a result of this approval and contains the same amounts of active ingredients as Excedrin(R) Extra Strength.
Indications
- arthralgia
- dental pain
- dysmenorrhea
- fever
- headache
- migraine
- mild pain
- moderate pain
- myalgia
For the temporary relief of mild pain to moderate pain associated with arthralgia, dental pain, dysmenorrhea, headache, myalgia, and/or premenstrual or menstrual cramps
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- aplastic anemia
- bleeding
- bronchospasm
- contact dermatitis
- diarrhea
- dizziness
- dyspepsia
- dysphagia
- edema
- elevated hepatic enzymes
- encephalopathy
- erythema
- erythema nodosum
- esophagitis
- exfoliative dermatitis
- fever
- GI bleeding
- GI perforation
- headache
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hepatitis
- hyperuricemia
- hypoprothrombinemia
- insomnia
- interstitial nephritis
- jaundice
- laryngeal edema
- lethargy
- leukocytosis
- leukopenia
- maculopapular rash
- methemoglobinemia
- nausea
- neutropenia
- odynophagia
- palpitations
- pancreatitis
- pancytopenia
- platelet dysfunction
- polyuria
- prolonged bleeding time
- proteinuria
- pruritus
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- Reye’s syndrome
- rhinitis
- sinus tachycardia
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytosis
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vomiting
- withdrawal
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum salicylate concentrations
Contraindications
- acetaminophen hypersensitivity
- acute bronchospasm
- alcoholism
- anemia
- anxiety
- asthma
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- coagulopathy
- diabetes mellitus
- G6PD deficiency
- geriatric
- hepatic disease
- hepatitis
- hypertension
- hypoprothrombinemia
- immunosuppression
- influenza
- insomnia
- intramuscular injections
- labor
- myocardial infarction
- nasal polyps
- neutropenia
- NSAID hypersensitivity
- obstetric delivery
- panic disorder
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- salicylate hypersensitivity
- surgery
- systemic lupus erythematosus (SLE)
- thrombocytopenia
- thyroid disease
- varicella
- viral infection
- vitamin K deficiency
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Abciximab
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Acetohexamide
- Acidifying Agents
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Adenosine
- Ado-Trastuzumab emtansine
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alkalinizing Agents
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alpha-glucosidase Inhibitors
- Amantadine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Ampicillin
- Ampicillin; Sulbactam
- Anagrelide
- Angiotensin-converting enzyme inhibitors
- Antacids
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Aprepitant, Fosaprepitant
- Ardeparin
- Arformoterol
- Armodafinil
- Articaine; Epinephrine
- Ascorbic Acid, Vitamin C
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azilsartan; Chlorthalidone
- Bacitracin
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzphetamine
- Beta-agonists
- Beta-blockers
- Betrixaban
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bisphosphonates
- Boceprevir
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Busulfan
- Butabarbital
- Caffeine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capmatinib
- Capreomycin
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbenicillin
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cefixime
- Cefotetan
- Celecoxib
- Cetirizine; Pseudoephedrine
- Charcoal
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cilostazol
- Cimetidine
- Ciprofloxacin
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Citric Acid; Sodium Citrate
- Clomipramine
- Clopidogrel
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Collagenase
- Corticosteroids
- Cyclosporine
- Dabigatran
- Dalteparin
- Danazol
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Daratumumab; Hyaluronidase
- Darifenacin
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Defibrotide
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Dicloxacillin
- Diethylpropion
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Disulfiram
- Dobutamine
- Dopamine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Dyphylline
- Dyphylline; Guaifenesin
- Echinacea
- Edoxaban
- Efalizumab
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Ephedrine
- Epinephrine
- Epoprostenol
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esomeprazole; Naproxen
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etodolac
- Exenatide
- Famotidine; Ibuprofen
- Fenoprofen
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Furosemide
- Gallium Ga 68 Dotatate
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Givosiran
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- grapefruit juice
- Green Tea
- Griseofulvin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Heparin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibritumomab Tiuxetan
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloprost
- Imatinib
- Immune Globulin IV, IVIG, IGIV
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indomethacin
- Inotersen
- Insulin Glargine; Lixisenatide
- Insulins
- Intravenous Lipid Emulsions
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lamotrigine
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lesinurad
- Lesinurad; Allopurinol
- Levalbuterol
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lixisenatide
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Low Molecular Weight Heparins
- Macimorelin
- Magnesium Salicylate
- Mannitol
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Melatonin
- Meloxicam
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Metaproterenol
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methazolamide
- Methohexital
- Methotrexate
- Methyclothiazide
- Methylphenidate
- Methylsulfonylmethane, MSM
- Metoclopramide
- Metolazone
- Metyrapone
- Mexiletine
- Midodrine
- Mipomersen
- Mitotane
- Modafinil
- Moexipril
- Monoamine oxidase inhibitors
- Muromonab-CD3
- Mycophenolate
- Nabumetone
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nitazoxanide
- Nitroglycerin
- Non-Ionic Contrast Media
- Norepinephrine
- Obeticholic Acid
- Olodaterol
- Omacetaxine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxacillin
- Oxaprozin
- Oxybutynin
- Paroxetine
- Peginterferon Alfa-2b
- Pemoline
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Pentobarbital
- Pentosan
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Phosphorated Carbohydrate Solution
- Phosphorus
- Photosensitizing agents (topical)
- Pioglitazone
- Piperacillin
- Piperacillin; Tazobactam
- Pirbuterol
- Piroxicam
- Pneumococcal Vaccine, Polyvalent
- Polymyxins
- Posaconazole
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Pramlintide
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Prasugrel
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procarbazine
- Pseudoephedrine
- Psyllium
- Quinapril
- Racepinephrine
- Ramelteon
- Ramipril
- Rasagiline
- Regadenoson
- Repaglinide
- Rifabutin
- Rifampin
- Ritodrine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Ropivacaine
- Rosiglitazone
- Rucaparib
- Salicylic Acid
- Salmeterol
- Salsalate
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Sibutramine
- Simvastatin; Sitagliptin
- Sitagliptin
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Lactate
- Sodium Oxybate
- Sodium Thiosulfate; Salicylic Acid
- Solifenacin
- Solriamfetol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sulfinpyrazone
- Sulfonamides
- Sulfonylureas
- Sulindac
- Suvorexant
- Tacrolimus
- Tasimelteon
- Telaprevir
- Telavancin
- Telotristat Ethyl
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Terbutaline
- Teriflunomide
- Tetracaine
- Theophylline, Aminophylline
- Thiabendazole
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thrombin Inhibitors
- Thrombolytic Agents
- Ticagrelor
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Ticlopidine
- Tinzaparin
- Tiotropium; Olodaterol
- Tipranavir
- Tirofiban
- Tizanidine
- tobacco
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamterene
- Trimetrexate
- Tromethamine
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Vemurafenib
- Verapamil
- Verteporfin
- Vilazodone
- Vorapaxar
- Vortioxetine
- Warfarin
- Yohimbine
- Zafirlukast
- Zaleplon
- Zidovudine, ZDV
- Zileuton
- Zolmitriptan
- Zolpidem