Angiotensin 2

Angiotensin 2 Brand Name– GIAPREZA

What is Angiotensin 2

Angiotensin 2 is a renin-angiotensin-aldosterone system (RAAS) peptide hormone vasoconstrictor indicated for hypotension in adults with septic or other distributive shock.

In the ATHOS-3 clinical trial, mean arterial blood pressure (MAP) increased from baseline by 10 mm Hg or more or to 75 mm Hg or more without an increase in the dosage of baseline vasopressor therapy in more patients receiving angiotensin II than those receiving placebo (69.9% vs. 23.4%, p less than 0.001).

A higher incidence of arterial and venous thrombosis and thromboembolic events was reported among patients receiving angiotensin 2 compared to placebo; concurrent venous thromboembolism (VTE) prophylaxis is necessary with angiotensin 2 therapy.

Indications

  • hypotension
  • septic shock

For the treatment of hypotension in patients with septic shock or other distributive shock

Side Effects

  • delirium
  • hyperglycemia
  • infection
  • metabolic acidosis
  • sinus tachycardia
  • thrombocytopenia
  • thrombosis

During the ATHOS-3 clinical trial, peripheral ischemia was reported in 4.3% of patients receiving angiotensin II compared to 2.5% of those receiving placebo.

Monitoring Parameters

  • blood pressure

Contraindications

  • breast-feeding
  • pregnancy
  • thrombosis

Interactions

  • Aliskiren; Valsartan
  • Amlodipine; Benazepril
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Irbesartan
  • Lisinopril
  • Losartan
  • Moexipril
  • Nebivolol; Valsartan
  • Olmesartan
  • Perindopril
  • Perindopril; Amlodipine
  • Quinapril
  • Ramipril
  • Sacubitril; Valsartan
  • Telmisartan
  • Trandolapril
  • Trandolapril; Verapamil
  • Valsartan
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