Anidulafungin

Anidulafungin Brand Name– Eraxis

What is Anidulafungin

Anidulafungin, Eraxis™, is an intravenous echinocandin antifungal agent and is derived from echinocandin B0, a fermentation product of Aspergillus nidulans. Anidulafungin is active in vitro against Candida albicansC. glabrataC. parapsilosis, and C. tropicalis and has been used investigationally in combination with liposomal amphotericin B for the treatment of invasive aspergillosis.

Anidulafungin was approved for the treatment of candidemia and other Candida infections (intra-abdominal, peritonitis) and esophageal candidiasis in February 2006.

Indications

  1. Aspergillus flavus
  2. Aspergillus fumigatus
  3. Aspergillus niger
  4. Aspergillus sp.
  5. Aspergillus terreus
  6. bone and joint infections
  7. Candida albicans
  8. Candida glabrata
  9. Candida guilliermondii
  10. Candida krusei
  11. Candida lusitaniae
  12. Candida parapsilosis
  13. Candida tropicalis
  14. candidemia
  15. candidiasis
  16. candidiasis prophylaxis
  17. endocarditis
  18. esophageal candidiasis
  19. infectious arthritis
  20. intraabdominal abscess
  21. intraabdominal infections
  22. oropharyngeal candidiasis (thrush)
  23. osteomyelitis
  24. peritonitis
  25. pneumonia

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anemia
  5. angioedema
  6. arrhythmia exacerbation
  7. atrial fibrillation
  8. back pain
  9. blurred vision
  10. bronchospasm
  11. bundle-branch block
  12. candidiasis
  13. chest pain (unspecified)
  14. cholestasis
  15. coagulopathy
  16. confusion
  17. constipation
  18. cough
  19. dehydration
  20. depression
  21. diarrhea
  22. dizziness
  23. dyspepsia
  24. dyspnea
  25. elevated hepatic enzymes
  26. erythema
  27. fever
  28. flushing
  29. headache
  30. hepatic failure
  31. hepatic necrosis
  32. hepatitis
  33. hyperamylasemia
  34. hyperbilirubinemia
  35. hyperglycemia
  36. hyperhidrosis
  37. hyperkalemia
  38. hypertension
  39. hypoglycemia
  40. hypokalemia
  41. hypomagnesemia
  42. hypotension
  43. infection
  44. infusion-related reactions
  45. insomnia
  46. leukocytosis
  47. nausea
  48. ocular pain
  49. peripheral edema
  50. phlebitis
  51. pleural effusion
  52. pruritus
  53. QT prolongation
  54. rash
  55. seizures
  56. skin ulcer
  57. thrombocytopenia
  58. thrombocytosis
  59. thrombosis
  60. urticaria
  61. visual impairment
  62. vomiting

Monitoring Parameters

  • LFTs

Contraindications

  • breast-feeding
  • children
  • hepatic disease
  • infants
  • pregnancy

Interactions

  • Dichlorphenamide
  • Saccharomyces boulardii
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