Amobarbital

Amobarbital Brand Name– Amytal

What is Amobarbital

Amobarbital sodium is a parenteral barbiturate. Single ingredient oral amobarbital is no longer commercially available in the US. Amobarbital is longer acting than either pentobarbital or secobarbital but shorter acting than phenobarbital.

Amobarbital has been used clinically for the short-term treatment of insomnia, to relieve preoperative anxiety and produce sedation, and to control seizures occurring with status epilepticus or with acute seizure episodes from toxins, meningitis, or eclampsia.

Amobarbital is a pre-1938 drug and was approved by the FDA in 1938, it is seldom used today.

Indications

• insomnia
• procedural sedation
• tonic-clonic seizures

Side Effects

1. agitation
2. angioedema
3. anxiety
4. apnea
5. ataxia
6. bradycardia
7. confusion
8. constipation
9. depression
10. dizziness
11. drowsiness
12. exfoliative dermatitis
13. hallucinations
14. headache
15. hyperkinesis
16. hypotension
17. hypoventilation
18. injection site reaction
19. insomnia
20. irritability
21. laryngospasm
22. lethargy
23. miosis
24. mydriasis
25. nausea
26. nightmares
27. nystagmus
28. physiological dependence
29. psychomotor impairment
30. ptosis
31. rash
32. respiratory depression
33. syncope
34. vertigo
35. vomiting
36. withdrawal

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• abrupt discontinuation
• adrenal insufficiency
• agranulocytosis
• alcoholism
• anticoagulant therapy
• barbiturate hypersensitivity
• breast-feeding
• carbamazepine hypersensitivity
• children
• chronic obstructive pulmonary disease (COPD)
• CNS depression
• coadministration with other CNS depressants
• complex sleep-related behaviors
• depression
• driving or operating machinery
• ethanol ingestion
• exfoliative dermatitis
• extravasation
• geriatric
• hepatic disease
• hepatic encephalopathy
• hydantoin hypersensitivity
• hypotension
• infants
• intraarterial administration
• labor
• neonates
• obstetric delivery
• pain
• porphyria
• pregnancy
• premature neonates
• pulmonary disease
• renal failure
• renal impairment
• requires a specialized care setting
• respiratory depression
• respiratory insufficiency
• sleep apnea
• subcutaneous administration
• substance abuse
• suicidal ideation
• tissue necrosis

Interactions

• Abemaciclib
• Acebutolol
• Acetaminophen
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alprazolam
• Altretamine
• Amiloride
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• Aminosalicylate sodium, Aminosalicylic acid
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• Amlodipine; Celecoxib
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• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
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• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorthalidone
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• Choline Salicylate; Magnesium Salicylate
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• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
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• Dextromethorphan; Quinidine
• Diazepam
• Diazoxide
• Diclofenac
• Diclofenac; Misoprostol
• Dicyclomine
• Dienogest; Estradiol valerate
• Diethylstilbestrol, DES
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
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• Donepezil
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• Doxazosin
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• Doxorubicin
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• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
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• Empagliflozin; Linagliptin; Metformin
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• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Entacapone
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• Epinephrine
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• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
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• Ethosuximide
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• food
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• Green Tea
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• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanfacine
• Haloperidol
• Hemin
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• Hydantoins
• Hydralazine
• Hydralazine; Hydrochlorothiazide, HCTZ
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• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
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• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
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