Amoxapine

What is Amoxapine

Amoxapine is an antidepressant of the dibenzoxazepine class. It is a cyclic antidepressant chemically distinct from other cyclic compounds for depression, such as tricyclic antidepressants (TCAs), but possesses some pharmacologic actions that are similar to TCAs, including norepinephrine reuptake inhibition.

Amoxapine differs from other conventional antidepressants in that it also has dopamine antagonist properties, and, it appears to have a low propensity for serotonergic effects.

Amoxapine is indicated for the treatment of major depression in adults, including depression with psychotic features, concurrent anxiety, or agitation.

Due to the availability of antidepressants with a more acceptable tolerability and safety profile, amoxapine is generally not considered a first-line treatment option.

Product labels for all antidepressants contain a warning related to an increased risk of suicidality in children, adolescents, and young adults during the initial stages of therapy with an antidepressant, whether treating depression or other psychiatric conditions.

Therefore, the necessity of pharmacologic therapy should be carefully considered in these populations, taking into account the risks of treatment versus clinical need.

Indications

  • depression

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. alopecia
  5. anorexia
  6. anxiety
  7. appetite stimulation
  8. asthenia
  9. ataxia
  10. atrial fibrillation
  11. AV block
  12. blurred vision
  13. breast enlargement
  14. confusion
  15. constipation
  16. cycloplegia
  17. depression
  18. diarrhea
  19. dizziness
  20. drowsiness
  21. dysgeusia
  22. edema
  23. EEG changes
  24. ejaculation dysfunction
  25. eosinophilia
  26. fatigue
  27. fever
  28. flatulence
  29. galactorrhea
  30. hallucinations
  31. headache
  32. hepatitis
  33. hyperhidrosis
  34. hyperprolactinemia
  35. hypertension
  36. hyperthermia
  37. hypotension
  38. ileus
  39. impotence (erectile dysfunction)
  40. increased urinary frequency
  41. insomnia
  42. jaundice
  43. lacrimation
  44. leukopenia
  45. libido decrease
  46. libido increase
  47. mania
  48. menstrual irregularity
  49. mydriasis
  50. myocardial infarction
  51. nasal congestion
  52. nausea
  53. neuroleptic malignant syndrome
  54. nightmares
  55. ocular hypertension
  56. orthostatic hypotension
  57. palpitations
  58. pancreatitis
  59. paresthesias
  60. parotitis
  61. petechiae
  62. photosensitivity
  63. pruritus
  64. purpura
  65. rash
  66. restlessness
  67. seizures
  68. SIADH
  69. sinus tachycardia
  70. stroke
  71. suicidal ideation
  72. syncope
  73. tardive dyskinesia
  74. testicular swelling
  75. thrombocytopenia
  76. tinnitus
  77. tremor
  78. urinary retention
  79. urticaria
  80. vasculitis
  81. visual impairment
  82. vomiting
  83. weight gain
  84. weight loss
  85. xerostomia

Monitoring Parameters

  • ECG
  • LFTs
  • serum amoxapine concentrations
  • thyroid function tests (TFTs)

Contraindications

  • abrupt discontinuation
  • acute myocardial infarction
  • agranulocytosis
  • alcoholism
  • anticholinergic medications
  • asthma
  • bipolar disorder
  • breast-feeding
  • carbamazepine hypersensitivity
  • cardiac arrhythmias
  • cardiac disease
  • children
  • closed-angle glaucoma
  • diabetes mellitus
  • driving or operating machinery
  • electroconvulsive therapy (ECT)
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI disease
  • hematological disease
  • hepatic disease
  • hyperthermia
  • hyperthyroidism
  • hypothyroidism
  • ileus
  • increased intraocular pressure
  • MAOI therapy
  • Parkinson’s disease
  • pregnancy
  • prostatic hypertrophy
  • radiographic contrast administration
  • respiratory depression
  • schizophrenia
  • seizure disorder
  • seizures
  • suicidal ideation
  • sunlight (UV) exposure
  • surgery
  • tachycardia
  • tardive dyskinesia
  • thrombocytopenia
  • tricyclic antidepressant hypersensitivity
  • urinary retention

Interactions

  • Abiraterone
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Alosetron
  • Alprazolam
  • Amantadine
  • Ambenonium Chloride
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Celecoxib
  • Amobarbital
  • Amphetamine; Dextroamphetamine Salts
  • Amprenavir
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Aripiprazole
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brexpiprazole
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Celecoxib
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cholinergic agonists
  • Cimetidine
  • Cinacalcet
  • Clemastine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Dacomitinib
  • Dantrolene
  • Darifenacin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Disulfiram
  • Dobutamine
  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Edrophonium
  • Ephedrine
  • Epinephrine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethotoin
  • Everolimus
  • Fedratinib
  • Felbamate
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Flecainide
  • Flumazenil
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fosphenytoin
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Givosiran
  • Goserelin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Guselkumab
  • Haloperidol
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Imatinib
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Isocarboxazid
  • Isoproterenol
  • Isosulfan Blue
  • Labetalol
  • Lasmiditan
  • Lemborexant
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levocetirizine
  • Levodopa
  • Levorphanol
  • Linezolid
  • Lofexidine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mesoridazine
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyldopa
  • Methylene Blue
  • Methylphenidate
  • Metoclopramide
  • Midazolam
  • Midodrine
  • Minocycline
  • Mirabegron
  • Mirtazapine
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Naproxen; Pseudoephedrine
  • Neostigmine
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Orphenadrine
  • Osilodrostat
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Physostigmine
  • Pimozide
  • Pramipexole
  • Pregabalin
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propoxyphene
  • Pseudoephedrine
  • Pyridostigmine
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Risperidone
  • Ritodrine
  • Ritonavir
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Secobarbital
  • Sedating H1-blockers
  • Selegiline
  • Sertraline
  • Solifenacin
  • St. John’s Wort, Hypericum perforatum
  • Succinimides
  • Sufentanil
  • Tacrine
  • Tapentadol
  • Temazepam
  • Terbinafine
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Thyroid hormones
  • Tipranavir
  • Tolterodine
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Triprolidine
  • Triptorelin
  • Trospium
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top