Albiglutide Brand Name– Tanzeum
What is Albiglutide
Albiglutide is a synthetic glucagon-like peptide-1 receptor agonist (GLP-1 RA) and belongs to a class of antidiabetic agents called incretin mimetics. Incretins are endogenous compounds, including glucagon-like peptide-1 (GLP-1), that improve glycemic control once released into the circulation via the gut.
Albiglutide subcutaneous injection is given just once weekly and is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus (DM).
As with other agents in this class, albiglutide is not recommended as first-line therapy for patients who have inadequate glycemic control on diet and exercise because of the boxed warning regarding rodent C-cell tumor findings and the uncertain relevance to humans.
Indications
- type 2 diabetes mellitus
For the treatment of type 2 diabetes mellitus in combination with diet and exercise
Side Effects
- angioedema
- antibody formation
- arthralgia
- atrial fibrillation
- atrial flutter
- back pain
- constipation
- cough
- dehydration
- diarrhea
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- erythema
- gastroesophageal reflux
- hematoma
- hypoglycemia
- infection
- influenza
- injection site reaction
- nausea
- new primary malignancy
- pancreatitis
- pruritus
- rash
- renal failure (unspecified)
- sinusitis
- vomiting
Monitoring Parameters
- blood glucose
- glycosylated hemoglobin A1c (HbA1c)
Contraindications
- breast-feeding
- burns
- children
- colitis
- Crohn’s disease
- dehydration
- diabetic ketoacidosis
- diarrhea
- fever
- gastroparesis
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- GI perforation
- history of angioedema
- hypoglycemia
- ileus
- infants
- infection
- inflammatory bowel disease
- medullary thyroid carcinoma (MTC)
- multiple endocrine neoplasia syndrome type 2 (MEN 2)
- neonates
- pancreatitis
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- serious hypersensitivity reactions or anaphylaxis
- surgery
- thyroid C-cell tumors
- thyroid cancer
- thyroid disease
- tobacco smoking
- trauma
- type 1 diabetes mellitus
- ulcerative colitis
- vomiting
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetazolamide
- Aliskiren; Valsartan
- Aminosalicylate sodium, Aminosalicylic acid
- Amlodipine; Benazepril
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Androgens
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- atypical antipsychotic
- Azilsartan
- Azilsartan; Chlorthalidone
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Beta-blockers
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bortezomib
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
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- Chloroquine
- Chlorpromazine
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
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- Clonidine
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- Codeine; Promethazine
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
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- Diazoxide
- Dienogest; Estradiol valerate
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- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esterified Estrogens; Methyltestosterone
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Ethanol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etonogestrel
- Fibric acid derivatives
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluoxymesterone
- Fluphenazine
- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Garlic, Allium sativum
- Glecaprevir; Pibrentasvir
- Green Tea
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydroxychloroquine
- Hydroxyprogesterone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indapamide
- Indinavir
- Insulin Detemir
- Irbesartan
- Isocarboxazid
- Lanreotide
- Ledipasvir; Sofosbuvir
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- Linezolid
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- Lovastatin; Niacin
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- Meperidine; Promethazine
- Mesoridazine
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- Moexipril
- Monoamine oxidase inhibitors
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- Nebivolol; Valsartan
- Nelfinavir
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- Nicotine
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- Octreotide
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- Phenylephrine; Promethazine
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- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
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- Prochlorperazine
- Progesterone
- Progestins
- Promethazine
- Protease inhibitors
- Quinapril
- Quinolones
- Ramipril
- Reserpine
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- Saquinavir
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- Selegiline
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- Tipranavir
- tobacco
- Trandolapril
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- Tranylcypromine
- Triamterene
- Trifluoperazine
- Valsartan