Amlodipine and Atorvastatin

Amlodipine and Atorvastatin Brand Name– Caduet

What is Amlodipine and Atorvastatin

Amlodipine and atorvastatin (CADUET) is a combination product which may be substituted for its individually titrated components.

Amlodipine, a calcium-channel blocker and potent vasodilator, is used for the treatment of hypertension, chronic stable angina pectoris, and/or Prinzmetal’s variant angina.

Amlodipine has the longest half-life of the calcium-channel blocker group, thus allowing for once-daily dosing. Atorvastatin is an HMG-CoA reductase inhibitor which is primarily used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia.

Atorvastatin may also be used in the treatment of homozygous familial hypercholesterolemia.

CADUET was approved by the FDA on January 30, 2004.

Indications

  1. angina
  2. hypercholesterolemia
  3. hyperlipoproteinemia
  4. hypertension
  5. hypertriglyceridemia
  6. myocardial infarction prophylaxis
  7. stroke prophylaxis
  8. variant angina

NOTE: Patients receiving amlodipine; atorvastatin therapy should also be placed on a standard cholesterol-lowering diet, and this diet should be continued throughout therapy. Serum lipoprotein concentrations should be determined periodically and dosage adjusted according to individual response and established NCEP treatment guidelines.

Side Effects

  1. abdominal pain
  2. amnesia
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. anorexia
  7. arrhythmia exacerbation
  8. arthralgia
  9. atrial fibrillation
  10. back pain
  11. bradycardia
  12. bullous rash
  13. chest pain (unspecified)
  14. cholestasis
  15. cirrhosis
  16. Co-Enzyme Q-10 deficiency
  17. confusion
  18. constipation
  19. diabetes mellitus
  20. diaphoresis
  21. diarrhea
  22. dizziness
  23. drowsiness
  24. dysarthria
  25. dyspepsia
  26. dysphagia
  27. dyspnea
  28. edema
  29. elevated hepatic enzymes
  30. erythema multiforme
  31. fatigue
  32. fever
  33. flatulence
  34. flushing
  35. gingival hyperplasia
  36. gynecomastia
  37. headache
  38. hepatic failure
  39. hepatic necrosis
  40. hepatitis
  41. hyperglycemia
  42. hypoesthesia
  43. hypotension
  44. immune-mediated necrotizing myopathy
  45. interstitial lung disease
  46. jaundice
  47. leukopenia
  48. maculopapular rash
  49. malaise
  50. memory impairment
  51. muscle paralysis
  52. myalgia
  53. myasthenia
  54. myoglobinuria
  55. myopathy
  56. nausea
  57. orthostatic hypotension
  58. palpitations
  59. pancreatitis
  60. paresthesias
  61. peripheral edema
  62. peripheral neuropathy
  63. peripheral vasodilation
  64. pharyngitis
  65. pruritus
  66. purpura
  67. rash
  68. renal failure (unspecified)
  69. rhabdomyolysis
  70. sinus tachycardia
  71. Stevens-Johnson syndrome
  72. stroke
  73. syncope
  74. thrombocytopenia
  75. toxic epidermal necrolysis
  76. tremor
  77. urticaria
  78. vasculitis
  79. ventricular tachycardia
  80. vertigo
  81. vomiting
  82. weakness

Monitoring Parameters

  • blood pressure
  • creatine phosphokinase (CPK)
  • heart rate
  • LFTs
  • serum cholesterol profile

Contraindications

  • acute myocardial infarction
  • alcoholism
  • aortic stenosis
  • bradycardia
  • breast-feeding
  • cardiogenic shock
  • children
  • cholestasis
  • contraception requirements
  • coronary artery disease
  • diabetes mellitus
  • dihydropyridine hypersensitivity
  • electrolyte imbalance
  • endocrine disease
  • geriatric
  • heart failure
  • hepatic disease
  • hepatic encephalopathy
  • hepatitis
  • hypertension
  • infants
  • infection
  • jaundice
  • myopathy
  • neonates
  • organ transplant
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk
  • rhabdomyolysis
  • seizure disorder
  • stroke
  • surgery
  • trauma
  • ventricular dysfunction

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
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  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
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