Amlodipine and Celecoxib Brand Name– CONSENSI
What is Amlodipine and Celecoxib
Amlodipine and celecoxib is an oral combination of a calcium channel blocker and nonsteroidal anti-inflammatory drug (NSAID), indicated for patients for whom treatment with amlodipine for hypertension and celecoxib for osteoarthritis are appropriate.
Amlodipine and celecoxib is inappropriate for short-term or intermittent treatment or for any condition other than hypertension in patients taking celecoxib.
Celecoxib, like all nonsteroidal anti-inflammatory drugs (NSAIDs), may exacerbate heart failure and hypertension and may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke as well as gastrointestinal adverse effects including bleeding, ulceration, and perforation of the stomach or intestines.
Careful patient selection and use of the lowest effective dose for the shortest possible duration are recommended.
If analgesic therapy is no longer needed, amlodipine; celecoxib may be discontinued for alternative antihypertensive monotherapy, such as amlodipine monotherapy.
Indications
- hypertension
- osteoarthritis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anosmia
- anxiety
- aplastic anemia
- arrhythmia exacerbation
- arthralgia
- aseptic meningitis
- asthenia
- ataxia
- atrial fibrillation
- azotemia
- back pain
- bradycardia
- bronchospasm
- chest pain (unspecified)
- chills
- cholelithiasis
- colitis
- conjunctivitis
- constipation
- contact dermatitis
- cough
- cyanosis
- cystitis
- depression
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- epistaxis
- eructation
- erythema
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- flushing
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI obstruction
- GI perforation
- gingival hyperplasia
- gynecomastia
- headache
- hearing loss
- heart failure
- hematuria
- hemorrhoids
- hepatic failure
- hepatitis
- hot flashes
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypernatremia
- hypertension
- hypertonia
- hypoesthesia
- hypoglycemia
- hypokalemia
- hyponatremia
- hypotension
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- infertility
- insomnia
- interstitial nephritis
- intracranial bleeding
- jaundice
- laryngitis
- leukopenia
- libido decrease
- maculopapular rash
- malaise
- melena
- methemoglobinemia
- migraine
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- nephrolithiasis
- nightmares
- nocturia
- ocular pain
- odynophagia
- orthostatic hypotension
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- peripheral edema
- peripheral neuropathy
- pharyngitis
- phlebitis
- photosensitivity
- polydipsia
- proteinuria
- pruritus
- pulmonary embolism
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- rhinitis
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- synovitis
- tenesmus
- thrombocytopenia
- thromboembolism
- thrombosis
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vasculitis
- ventricular fibrillation
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- xerosis
- xerostomia
Monitoring Parameters
- blood pressure
- CBC
- heart rate
- LFTs
- serum creatinine/BUN
- stool guaiac
Contraindications
- acute bronchospasm
- acute myocardial infarction
- alcoholism
- anemia
- angina
- anticoagulant therapy
- aortic stenosis
- asthma
- Black patients
- bone marrow suppression
- breast-feeding
- cardiac arrhythmias
- cerebrovascular disease
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- corticosteroid therapy
- dehydration
- geriatric
- GI bleeding
- GI disease
- GI perforation
- heart failure
- hepatic disease
- hypertension
- hypovolemia
- immunosuppression
- infertility
- jaundice
- labor
- myocardial infarction
- nasal polyps
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- renal failure
- renal impairment
- reproductive risk
- salicylate hypersensitivity
- serious rash
- stroke
- sulfonamide hypersensitivity
- tachycardia
- thromboembolism
- tobacco smoking
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetohexamide
- Acrivastine; Pseudoephedrine
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alpelisib
- Alpha-blockers
- Alprostadil
- Alteplase
- Altretamine
- Ambenonium Chloride
- Amifostine
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
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- Amphotericin B lipid complex (ABLC)
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- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
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- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
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- Dextromethorphan; Promethazine
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- Diethylpropion
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- Empagliflozin; Linagliptin; Metformin
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- Emtricitabine; Tenofovir alafenamide
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- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
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- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
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- Ethosuximide
- Ethotoin
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- Fluvoxamine
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- Hydrocodone
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- Phenelzine
- Phenoxybenzamine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Physostigmine
- Pimozide
- Pindolol
- Piroxicam
- Platelet Inhibitors
- Pneumococcal Vaccine, Polyvalent
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polymyxin B
- Polymyxins
- Posaconazole
- Potassium
- Pralatrexate
- Prasugrel
- Prazosin
- Prednisolone
- Prednisone
- Probenecid
- Procainamide
- Procaine
- Procarbazine
- Promethazine
- Propafenone
- Propofol
- Propoxyphene
- Propranolol
- Protease inhibitors
- Protriptyline
- Pseudoephedrine
- Pyridostigmine
- Quinapril
- Quinidine
- Quinine
- Quinolones
- Ramipril
- Rasagiline
- Remifentanil
- Reserpine
- Reteplase, r-PA
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rivaroxaban
- Rivastigmine
- Rofecoxib
- Rucaparib
- Sacubitril; Valsartan
- Salsalate
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Sertraline
- Sevoflurane
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sincalide
- Sirolimus
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Streptokinase
- Streptomycin
- Streptozocin
- Sufentanil
- Sulfasalazine
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Tacrine
- Tacrolimus
- Tamsulosin
- Telaprevir
- Telavancin
- Telbivudine
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temozolomide
- Temsirolimus
- Tenecteplase
- Teniposide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terazosin
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiazide diuretics
- Thioguanine, 6-TG
- Thioridazine
- Thiothixene
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Timolol
- Tinzaparin
- Tipranavir
- Tirofiban
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tositumomab
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamcinolone
- Triamterene
- Trimipramine
- Tucatinib
- Urea
- Urokinase
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vancomycin
- Vasodilators
- Vemurafenib
- Venlafaxine
- Verapamil
- Verteporfin
- Vilazodone
- Vinblastine
- Vinorelbine
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Warfarin
- Yohimbine
- Zafirlukast
- Ziprasidone
