Altretamine

Altretamine Brand Name– Hexalen

What is Altretamine

Altretamine is a synthetic antineoplastic agent effective in the treatment of some ovarian tumors resistant to alkylating agents.

It is an s-triazine derivative and is commercially available as an oral capsule.

Its unique mechanism of action is not related to any other commercially available antineoplastic.

Altretamine is also known as hexamethylmelamine, often abbreviated HMM.

Indications

  • ovarian cancer

For the palliative treatment of recurrent or persistent ovarian cancer as a single agent following first-line combination chemotherapy

Side Effects

  1. alopecia
  2. anemia
  3. anorexia
  4. ataxia
  5. azotemia
  6. bone marrow suppression
  7. confusion
  8. depression
  9. dizziness
  10. elevated hepatic enzymes
  11. fatigue
  12. leukopenia
  13. nausea
  14. neurotoxicity
  15. peripheral neuropathy
  16. pruritus
  17. rash
  18. seizures
  19. thrombocytopenia
  20. vertigo
  21. vomiting

Monitoring Parameters

  • CBC with differential
  • neurologic function
  • platelet count

Contraindications

  • bone marrow suppression
  • breast-feeding
  • children
  • dental disease
  • dental work
  • herpes infection
  • infection
  • intramuscular injections
  • MAOI therapy
  • neurotoxicity
  • neutropenia
  • pregnancy
  • radiation therapy
  • requires an experienced clinician
  • thrombocytopenia
  • vaccination
  • varicella
  • viral infection

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Aldesleukin, IL-2
  • Alpha interferons
  • Alteplase
  • Amlodipine; Celecoxib
  • Amobarbital
  • Anticoagulants
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Argatroban
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Bacillus Calmette-Guerin Vaccine, BCG
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betamethasone
  • Betrixaban
  • Bivalirudin
  • Budesonide
  • Budesonide; Formoterol
  • Butabarbital
  • Carbamazepine
  • Celecoxib
  • Ciclesonide
  • Cimetidine
  • Clozapine
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Deflazacort
  • Desirudin
  • Dexamethasone
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Digoxin
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Echinacea
  • Edoxaban
  • Enoxaparin
  • Esomeprazole; Naproxen
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Filgrastim, G-CSF
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fondaparinux
  • Formoterol; Mometasone
  • Fosphenytoin
  • Heparin
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indomethacin
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Isocarboxazid
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lepirudin
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Mephobarbital
  • Methohexital
  • Methylprednisolone
  • Mometasone
  • Monoamine oxidase inhibitors
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nonsteroidal antiinflammatory drugs
  • Oxaprozin
  • Palifermin
  • Pegfilgrastim
  • Penicillamine
  • Pentobarbital
  • Pentosan
  • Phenelzine
  • Phenobarbital
  • Phenytoin
  • Piroxicam
  • Platelet Inhibitors
  • Prednisolone
  • Prednisone
  • Primidone
  • Pyridoxine, Vitamin B6
  • Rasagiline
  • Reteplase, r-PA
  • Rifampin
  • Rivaroxaban
  • Rofecoxib
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Secobarbital
  • Selegiline
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Streptokinase
  • Sulindac
  • Tbo-Filgrastim
  • Tenecteplase
  • Thiopental
  • Thrombolytic Agents
  • Tinzaparin
  • Tolmetin
  • Tranylcypromine
  • Triamcinolone
  • Tuberculin Purified Protein Derivative, PPD
  • Typhoid Vaccine
  • Urokinase
  • Valdecoxib
  • Varicella-Zoster Virus Vaccine, Live
  • Warfarin
  • Yellow Fever Vaccine, Live
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