Vaccinia Vaccine

What is Vaccinia Vaccine

The vaccine used for prophylaxis against smallpox is called vaccinia vaccine and is a parenteral preparation of live, laboratory-derived vaccinia virus. Vaccinia virus is used because it is antigenically similar to the variola virus. The smallpox vaccine does not contain smallpox virus (variola) and cannot spread or cause smallpox.

Most estimates suggest immunity from the vaccinia vaccine lasts 3 to 5 years. Immunity can be boosted effectively with a single revaccination. Prior infection with the disease grants lifelong immunity. Post-exposure vaccination may be effective if given within 4 days of exposure to smallpox.

Vaccinia vaccination is generally considered very safe; serious complications are rare but include a risk of fatality in roughly 1—2 per million persons receiving primary vaccination and 0.25 deaths/million persons receiving revaccination.

Brand Name

Dryvax

Indications & Dosage

  • monkeypox prophylaxis
  • variola (smallpox) prophylaxis

Side Effects

  1. angina
  2. arthralgia
  3. back pain
  4. cardiomyopathy
  5. chest pain (unspecified)
  6. chills
  7. coma
  8. constipation
  9. diarrhea
  10. dizziness
  11. drowsiness
  12. eczema vaccinatum
  13. encephalopathy
  14. erythema
  15. erythema multiforme
  16. fatigue
  17. fetal death
  18. fever
  19. folliculitis
  20. generalized vaccinia
  21. Guillain-Barre syndrome
  22. headache
  23. injection site reaction
  24. lymphadenopathy
  25. maculopapular rash
  26. malaise
  27. meningitis
  28. muscle paralysis
  29. myalgia
  30. myelitis
  31. myocardial infarction
  32. myocarditis
  33. nausea
  34. paresthesias
  35. pericardial effusion
  36. pericarditis
  37. photophobia
  38. pruritus
  39. rash
  40. seizures
  41. Stevens-Johnson syndrome
  42. urticaria
  43. vaccinia necrosum (progressive vaccinia)
  44. vertigo
  45. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acne vulgaris
  • acquired immunodeficiency syndrome (AIDS)
  • albumin hypersensitivity
  • angina
  • atopy
  • autoimmune disease
  • blood donation
  • bone marrow suppression
  • breast-feeding
  • burns
  • cardiac disease
  • cardiomyopathy
  • children
  • coronary artery disease
  • diabetes mellitus
  • eczema
  • encephalopathy
  • exfoliative dermatitis
  • glycerin hypersensitivity
  • heart failure
  • herpes infection
  • human immunodeficiency virus (HIV) infection
  • hypercholesterolemia
  • hyperglycemia
  • hypertension
  • immunosuppression
  • infants
  • infection
  • latex hypersensitivity
  • mannitol hypersensitivity
  • myocardial infarction
  • myocarditis
  • neomycin hypersensitivity
  • neonates
  • ocular disease
  • pericarditis
  • polymyxin hypersensitivity
  • pregnancy
  • psoriasis
  • severe combined immunodeficiency (SCID)
  • streptomycin hypersensitivity
  • stroke
  • syphilis
  • systemic lupus erythematosus (SLE)
  • tetracyclines hypersensitivity
  • tobacco smoking
  • tuberculosis
  • varicella

Interactions

  • Abatacept
  • Adalimumab
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Alkylating agents
  • Alpha interferons
  • Altretamine
  • Anakinra
  • Anthracyclines
  • Antimetabolites
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Axicabtagene Ciloleucel
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Belatacept
  • Belimumab
  • Bexarotene
  • Blinatumomab
  • Brodalumab
  • Busulfan
  • Canakinumab
  • Carmustine, BCNU
  • Certolizumab pegol
  • Chlorambucil
  • Cisplatin
  • Clofarabine
  • Cortisone
  • Cyclophosphamide
  • Cyclosporine
  • Cytarabine, ARA-C
  • Dacarbazine, DTIC
  • Daclizumab
  • Deflazacort
  • Dexamethasone
  • Docetaxel
  • Dupilumab
  • Efalizumab
  • Emapalumab
  • Estramustine
  • Etanercept
  • Everolimus
  • Fingolimod
  • Floxuridine
  • Fludrocortisone
  • Fluorouracil, 5-FU
  • Folate analogs
  • Golimumab
  • Guselkumab
  • Hydrocortisone
  • Ifosfamide
  • Imatinib
  • Infliximab
  • Interferon Gamma-1b
  • Ixabepilone
  • Ixekizumab
  • Leflunomide
  • Lenalidomide
  • Lomustine, CCNU
  • Mechlorethamine, Nitrogen Mustard
  • Melphalan
  • Methylprednisolone
  • Mitoxantrone
  • Muromonab-CD3
  • Mycophenolate
  • Natalizumab
  • Nelarabine
  • Nilotinib
  • Obinutuzumab
  • Ocrelizumab
  • Ofatumumab
  • Ozanimod
  • Paclitaxel
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Purine analogs
  • Rilonacept
  • Risankizumab
  • Rituximab
  • Rituximab; Hyaluronidase
  • Sarilumab
  • Secukinumab
  • Siltuximab
  • Siponimod
  • Sirolimus
  • Streptozocin
  • Tacrolimus
  • Temozolomide
  • Temsirolimus
  • Teriflunomide
  • Thiotepa
  • Tildrakizumab
  • Tisagenlecleucel
  • Tocilizumab
  • Tofacitinib
  • Tositumomab
  • Triamcinolone
  • Ustekinumab
  • Vedolizumab
  • Venetoclax
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top