Typhoid Vaccine

What is Typhoid Vaccine

Typhoid vaccine is available as a sterile solution containing purified Vi polysaccharide extracted from the bacterial capsule of Salmonella typhi for intramuscular use (Typhim Vi) or a live attenuated vaccine for oral use (Vivotif).

These preparations are used to promote active immunity to typhoid fever for individuals who are at risk of infection.

Routine vaccination with typhoid vaccine is not recommended in the US.

Selective vaccination is recommended for persons who travel to areas where there is a recognized risk of exposure to S. typhi, persons with intimate exposure to a documented S. typhi carrier, and persons who frequently work with S. typhi in microbiology laboratories.

Brand Names

  • Typhim Vi
  • Vivotif (PaxVax, Inc.)
  • Vivotif Berna

Indications

  • typhoid prophylaxis

For primary immunization against typhoid disease cause by Salmonella typhi (typhoid prophylaxis) in persons at risk of infection

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angioedema
  5. arthralgia
  6. asthenia
  7. diarrhea
  8. dyspnea
  9. erythema
  10. fever
  11. glomerulonephritis
  12. headache
  13. hypotension
  14. injection site reaction
  15. lymphadenopathy
  16. malaise
  17. myalgia
  18. nausea
  19. neutropenia
  20. pruritus
  21. rash
  22. seizures
  23. serum sickness
  24. syncope
  25. tremor
  26. urticaria
  27. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • agammaglobulinemia
  • anticoagulant therapy
  • breast-feeding
  • chemotherapy
  • children
  • coagulopathy
  • corticosteroid therapy
  • diarrhea
  • fever
  • hemophilia
  • human immunodeficiency virus (HIV) infection
  • hypogammaglobulinemia
  • immunosuppression
  • infants
  • infection
  • intravenous administration
  • leukemia
  • lymphoma
  • neonates
  • neoplastic disease
  • pregnancy
  • radiation therapy
  • severe combined immunodeficiency (SCID)
  • subcutaneous administration
  • thrombocytopenia
  • vitamin K deficiency
  • vomiting
  • yeast hypersensitivity

Interactions

  • Abatacept
  • Adalimumab
  • Aldesleukin, IL-2
  • Alefacept
  • Alemtuzumab
  • Alkylating agents
  • Alpha interferons
  • Altretamine
  • Anakinra
  • Anthracyclines
  • Antimetabolites
  • Antithymocyte Globulin
  • Antitumor antibiotics
  • Atovaquone; Proguanil
  • Axicabtagene Ciloleucel
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Belatacept
  • Belimumab
  • Bexarotene
  • Blinatumomab
  • Brodalumab
  • Busulfan
  • Canakinumab
  • Carmustine, BCNU
  • Certolizumab pegol
  • Chlorambucil
  • Cisplatin
  • Clofarabine
  • Cortisone
  • Cyclophosphamide
  • Cyclosporine
  • Cytarabine, ARA-C
  • Dacarbazine, DTIC
  • Daclizumab
  • Deflazacort
  • Dexamethasone
  • Docetaxel
  • Dupilumab
  • Efalizumab
  • Emapalumab
  • Erythromycin; Sulfisoxazole
  • Estramustine
  • Etanercept
  • Everolimus
  • Fingolimod
  • Floxuridine
  • Fludrocortisone
  • Fluorouracil, 5-FU
  • Folate analogs
  • Golimumab
  • Guselkumab
  • Hydrocortisone
  • Ifosfamide
  • Imatinib
  • Infliximab
  • Interferon Gamma-1b
  • Ixabepilone
  • Ixekizumab
  • Leflunomide
  • Lenalidomide
  • Lomustine, CCNU
  • Mechlorethamine, Nitrogen Mustard
  • Mefloquine
  • Melphalan
  • Methylprednisolone
  • Mitoxantrone
  • Muromonab-CD3
  • Mycophenolate
  • Natalizumab
  • Nelarabine
  • Nilotinib
  • Obinutuzumab
  • Ocrelizumab
  • Ofatumumab
  • Ozanimod
  • Paclitaxel
  • Penicillins
  • Prednisolone
  • Prednisone
  • Procarbazine
  • Purine analogs
  • Pyrimethamine; Sulfadoxine
  • Rilonacept
  • Risankizumab
  • Rituximab
  • Rituximab; Hyaluronidase
  • Sarilumab
  • Secukinumab
  • Siltuximab
  • Siponimod
  • Sirolimus
  • Streptozocin
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Tacrolimus
  • Temozolomide
  • Temsirolimus
  • Teriflunomide
  • Thiotepa
  • Tildrakizumab
  • Tisagenlecleucel
  • Tocilizumab
  • Tofacitinib
  • Tositumomab
  • Triamcinolone
  • Ustekinumab
  • Vedolizumab
  • Venetoclax
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
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