Trolamine Salicylate

What is Trolamine Salicylate

Trolamine salicylate is an external analgesic and a chemical sunscreen agent. In 1983, the FDA classified trolamine salicylate as having unproven effectiveness and safety as an external analgesic.

One randomized double-blind crossover study of 25 patients with symptomatic osteoarthritis of the knee reported that trolamine salicylate 10% cream was no more effective than placebo.

However, in 1994, one manufacturer asked the FDA to reinvestigate trolamine salicylate based on data from unpublished studies which report trolamine salicylate to be effective in relieving the stiffness and pain associated with arthritis.

Further investigation is needed into the efficacy of trolamine salicylate as a topical analgesic. Trolamine salicylate is also used in sunscreen products as a UVB sunblock

Indications & Dosage

  • mild pain
  • musculoskeletal pain

For the topical treatment of mild pain including musculoskeletal pain and/or joint pain

Side Effects

  • contact dermatitis
  • folliculitis
  • skin irritation

Possible adverse reactions of trolamine salicylate include allergic contact dermatitis, folliculitis, photoallergic contact dermatitis, skin irritation, or skin rash.

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • infants
  • neonates
  • ophthalmic administration
  • pregnancy
  • salicylate hypersensitivity

Interactions

There are no drug interactions associated with Trolamine Salicylate products.

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