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Acetaminophen Caffeine Phenyltoloxamine Salicylamide Brand Names
Cafgesic | Combiflex | Durabac
What is Acetaminophen Caffeine Phenyltoloxamine Salicylamide
Acetaminophen Caffeine Phenyltoloxamine Salicylamide is a prescription combination product used for the temporary relief of mild to moderate pain and discomfort associated with simple headache, musculoskeletal pain, spasms, neuralgia, sinusitis, minor menstrual cramps, the common cold or grippe, toothache, and rheumatism or arthritis.
Indications
- common cold
- dental pain
- headache
- mild pain
- moderate pain
- muscle spasm
- osteoarthritis
- rheumatoid arthritis
- sinusitis
Side Effects
- abdominal pain
- acneiform rash
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- aplastic anemia
- asthenia
- AV block
- azotemia
- bleeding
- blurred vision
- bronchial secretions
- bronchospasm
- confusion
- constipation
- cyanosis
- dehydration
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dyspepsia
- ecchymosis
- elevated hepatic enzymes
- encephalopathy
- erythema
- erythema nodosum
- excitability
- exfoliative dermatitis
- fever
- flushing
- hallucinations
- headache
- heart failure
- hemolysis
- hemolytic anemia
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hypercalciuria
- hyperglycemia
- hypernatremia
- hypertension
- hyperuricemia
- hyperventilation
- hypoglycemia
- hypokalemia
- hypoprothrombinemia
- hypotension
- insomnia
- interstitial nephritis
- irritability
- jaundice
- lethargy
- leukocytosis
- leukopenia
- maculopapular rash
- methemoglobinemia
- mydriasis
- myocarditis
- nasal dryness
- nausea
- palpitations
- pancytopenia
- physiological dependence
- polydipsia
- polyuria
- proteinuria
- pruritus
- pulmonary edema
- purpura
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- respiratory depression
- restlessness
- Reye’s syndrome
- seizures
- sinus tachycardia
- thrombocytopenia
- thrombocytosis
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- toxic epidermal necrolysis
- tremor
- urinary retention
- urticaria
- visual impairment
- vomiting
- weakness
- wheezing
- xerophthalmia
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN: in chronic use or acute toxicity
Contraindications
- acetaminophen hypersensitivity
- acute bronchospasm
- alcoholism
- anemia
- angina
- anticoagulant therapy
- asthma
- bladder obstruction
- breast-feeding
- bronchitis
- cardiac arrhythmias
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- coagulopathy
- constipation
- contact lenses
- driving or operating machinery
- emphysema
- esophagitis
- G6PD deficiency
- gastritis
- geriatric
- GI bleeding
- GI disease
- GI obstruction
- GI perforation
- hemophilia
- hepatic disease
- hepatitis
- hypertension
- hypoprothrombinemia
- ileus
- increased intraocular pressure
- infants
- influenza
- MAOI therapy
- myocardial infarction
- nasal polyps
- neonates
- peptic ulcer disease
- pregnancy
- prostatic hypertrophy
- pulmonary disease
- pyloric stenosis
- renal disease
- renal failure
- renal impairment
- Reye’s syndrome
- salicylate hypersensitivity
- thrombolytic therapy
- thrombotic thrombocytopenic purpura (TTP)
- tobacco smoking
- ulcerative colitis
- urinary retention
- varicella
- viral infection
- vitamin K deficiency
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pentazocine
- Acetaminophen; Pseudoephedrine
- Acetazolamide
- Aclidinium; Formoterol
- Acrivastine; Pseudoephedrine
- Adenosine
- Albuterol
- Albuterol; Ipratropium
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Amantadine
- Ambenonium Chloride
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminoglycosides
- Amiodarone
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anagrelide
- Angiotensin-converting enzyme inhibitors
- Antacids
- Anticholinergics
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Aprepitant, Fosaprepitant
- Ardeparin
- Arformoterol
- Armodafinil
- Articaine; Epinephrine
- Ascorbic Acid, Vitamin C
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Bacitracin
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzodiazepines
- Benzphetamine
- Beta-agonists
- Beta-blockers
- Betaxolol
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide; Formoterol
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Busulfan
- Butabarbital
- Butorphanol
- Caffeine
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Canagliflozin
- Canagliflozin; Metformin
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capmatinib
- Capreomycin
- Capsaicin; Metaxalone
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carisoprodol
- Carteolol
- Carvedilol
- Cefixime
- Cefotetan
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Charcoal
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Chlorzoxazone
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cimetidine
- Ciprofloxacin
- Citalopram
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clobazam
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- COMT inhibitors
- Corticosteroids
- Cyclosporine
- Dabigatran
- Dalteparin
- Dantrolene
- Dapagliflozin
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Dapsone
- Daratumumab; Hyaluronidase
- Darifenacin
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Desloratadine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Disulfiram
- Dobutamine
- Dopamine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Dronabinol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Dyphylline
- Dyphylline; Guaifenesin
- Echinacea
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enoxaparin
- Entacapone
- Ephedrine
- Epinephrine
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Ertugliflozin; Sitagliptin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Escitalopram
- Esketamine
- Esmolol
- Esomeprazole; Naproxen
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethotoin
- Etodolac
- Etomidate
- Exenatide
- Famotidine; Ibuprofen
- Fenoprofen
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Flibanserin
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Furosemide
- Galantamine
- Gallium Ga 68 Dotatate
- Givosiran
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide; Metformin
- Glyburide; Metformin
- Glycopyrrolate; Formoterol
- grapefruit juice
- Green Tea
- Griseofulvin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Halogenated Anesthetics
- Heparin
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Imatinib
- Immune Globulin IV, IVIG, IGIV
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Inotersen
- Insulin Glargine; Lixisenatide
- Insulins
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lamotrigine
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lasmiditan
- Lemborexant
- Levalbuterol
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levomethadyl
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin
- Linagliptin; Metformin
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lixisenatide
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine
- Loratadine; Pseudoephedrine
- Low Molecular Weight Heparins
- Loxapine
- Lurasidone
- Macimorelin
- Magnesium Salicylate
- Magnesium Salts
- Mannitol
- Maprotiline
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Melatonin
- Meloxicam
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mestranol; Norethindrone
- Metaproterenol
- Metaxalone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methazolamide
- Methocarbamol
- Methohexital
- Methotrexate
- Methyclothiazide
- Methylphenidate
- Metoclopramide
- Metolazone
- Metoprolol
- Metyrapone
- Metyrosine
- Mexiletine
- Midodrine
- Minocycline
- Mipomersen
- Mirtazapine
- Mitotane
- Modafinil
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Mycophenolate
- Nabilone
- Nabumetone
- Nadolol
- Nalbuphine
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nitazoxanide
- Non-Ionic Contrast Media
- Norepinephrine
- Obeticholic Acid
- Olodaterol
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Orphenadrine
- Oxaprozin
- Oxybutynin
- Paliperidone
- Paroxetine
- Peginterferon Alfa-2b
- Pemoline
- Penbutolol
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Pentosan
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Phendimetrazine
- Phenelzine
- Phenobarbital
- Phentermine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Pioglitazone
- Pirbuterol
- Piroxicam
- Pitolisant
- Pneumococcal Vaccine, Polyvalent
- Polymyxins
- Posaconazole
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Pramipexole
- Pramlintide
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procarbazine
- Propofol
- Propranolol
- Pseudoephedrine
- Psyllium
- Quinapril
- Racepinephrine
- Ramelteon
- Ramipril
- Rasagiline
- Regadenoson
- Repaglinide
- Rifabutin
- Rifampin
- Risperidone
- Ritodrine
- Ritonavir
- Rituximab; Hyaluronidase
- Rivaroxaban
- Rivastigmine
- Ropinirole
- Ropivacaine
- Rosiglitazone
- Rucaparib
- Safinamide
- Salicylic Acid
- Salmeterol
- Salsalate
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Selegiline
- Serotonin norepinephrine reuptake inhibitors
- Sertraline
- Simvastatin; Sitagliptin
- Sincalide
- Sitagliptin
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Iodide
- Sodium Oxybate
- Sodium Thiosulfate; Salicylic Acid
- Solifenacin
- Solriamfetol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sulfinpyrazone
- Sulfonamides
- Sulindac
- Suvorexant
- Tacrine
- Tacrolimus
- Tasimelteon
- Telaprevir
- Telavancin
- Telotristat Ethyl
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terbinafine
- Terbutaline
- Teriflunomide
- Tetracaine
- Thalidomide
- Theophylline, Aminophylline
- Thiabendazole
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Thrombin Inhibitors
- Thrombolytic Agents
- Timolol
- Tinzaparin
- Tiotropium; Olodaterol
- Tizanidine
- tobacco
- Tolcapone
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Treprostinil
- Triamterene
- Tricyclic antidepressants
- Trimethobenzamide
- Trimetrexate
- Trospium
- Umeclidinium; Vilanterol
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Varicella-Zoster Virus Vaccine, Live
- Vemurafenib
- Verapamil
- Vigabatrin
- Vilazodone
- Vortioxetine
- Warfarin
- Yohimbine
- Zaleplon
- Ziconotide
- Zidovudine, ZDV
- Zileuton
- Zolmitriptan
- Zolpidem