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Acetaminophen and Diphenhydramine Brand Names
Aceta-Gesic | Bayer PM | Excedrin PM | Excedrin PM Express | Goody’s PM | Mapap PM | Midol PM | Percogesic | Percogesic Extra Strength | Tylenol Cold | Tylenol Cold Nighttime | Tylenol Day/Night Pack | Tylenol PM Extra Strength | Tylenol PM Extra Strength Rapid Release | Tylenol Severe Allergy | Tylenol Sore Throat Nighttime
What is Acetaminophen and Diphenhydramine
Acetaminophen and diphenhydramine are used together in an oral preparation either to provide temporary relief of occasional headache or mild aches and pain in patients with insomnia (sleeplessness) or to provide temporary relief of the symptoms of allergic respiratory conditions.
Acetaminophen is a non-narcotic, non-salicylate analgesic with similar potency to NSAIDs. Diphenhydramine is a sedating antihistamine (H1-blocker) of the ethanolamine class with strong anticholinergic activity commonly used to block histaminic responses and to facilitate sleep.
Acetaminophen; diphenhydramine has a significant potential for toxicity in overdose secondary to acetaminophen-induced hepatotoxicity and diphenhydramine-induced CNS depression.
Use with caution in patients with pre-existing hepatic impairment and in others with conditions that may result in an increased susceptibility to or likelihood of overdose.
Indications
- allergic conjunctivitis
- allergic rhinitis
- headache
- insomnia
- mild pain
- musculoskeletal pain
- ocular pruritus
- rhinorrhea
- sneezing
For the treatment of symptoms associated with allergic rhinitis (hay fever) or other respiratory allergies, such as allergic conjunctivitis with or without ocular pruritus, rhinorrhea, sneezing, sore throat, and pruritus of the nose or throat
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- angioedema
- anorexia
- appetite stimulation
- asthenia
- bleeding
- blurred vision
- confusion
- constipation
- cyanosis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- elevated hepatic enzymes
- erythema
- exfoliative dermatitis
- fatigue
- fever
- GI bleeding
- headache
- hemolytic anemia
- hepatic encephalopathy
- hepatic necrosis
- hypoprothrombinemia
- hypotension
- insomnia
- interstitial nephritis
- irritability
- jaundice
- maculopapular rash
- methemoglobinemia
- mydriasis
- nausea
- ocular hypertension
- palpitations
- pancytopenia
- photosensitivity
- pruritus
- rash
- renal papillary necrosis
- renal tubular necrosis
- restlessness
- seizures
- sinus tachycardia
- thrombocytopenia
- thrombocytosis
- tolerance
- toxic epidermal necrolysis
- urinary retention
- urticaria
- vomiting
- weakness
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acetaminophen hypersensitivity
- alcoholism
- anemia
- bladder obstruction
- bone marrow suppression
- breast-feeding
- bronchitis
- cardiac disease
- children
- closed-angle glaucoma
- constipation
- contact lenses
- cystic fibrosis
- driving or operating machinery
- emphysema
- ethanol intoxication
- G6PD deficiency
- geriatric
- GI obstruction
- hepatic disease
- hepatitis
- ileus
- immunosuppression
- infants
- malnutrition
- neonates
- neutropenia
- potential for overdose or poisoning
- pregnancy
- prostatic hypertrophy
- renal disease
- tobacco smoking
- urinary retention
- visual disturbance
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aldesleukin, IL-2
- Alfentanil
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amikacin
- Aminoglycosides
- Amlodipine; Celecoxib
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Antacids
- Anticholinergics
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Artemether; Lumefantrine
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir; Cobicistat
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzphetamine
- Bethanechol
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Busulfan
- Butabarbital
- Butorphanol
- Cannabidiol
- Capecitabine
- Capsaicin; Metaxalone
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Carisoprodol
- Celecoxib
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Charcoal
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Clobazam
- Clozapine
- Cobicistat
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclobenzaprine
- Dantrolene
- Dapsone
- Daratumumab; Hyaluronidase
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desloratadine
- Desloratadine; Pseudoephedrine
- Deutetrabenazine
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Dutasteride; Tamsulosin
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Entacapone
- Esketamine
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etomidate
- Exenatide
- Ezogabine
- Fenofibric Acid
- Fentanyl
- Flibanserin
- Fluoxetine; Olanzapine
- Fluphenazine
- Fospropofol
- Gabapentin
- Galantamine
- Gentamicin
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyprogesterone
- Ibuprofen; Oxycodone
- Iloperidone
- Imatinib
- Insulin Glargine; Lixisenatide
- Isavuconazonium
- Isocarboxazid
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ivacaftor
- Kanamycin
- Ketamine
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lanthanum Carbonate
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Lithium
- Lixisenatide
- Lofexidine
- Lomitapide
- Lopinavir; Ritonavir
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Luliconazole
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salicylate
- Magnesium Salts
- Maprotiline
- Meclizine
- Melatonin
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Metaxalone
- Methadone
- Methamphetamine
- Methocarbamol
- Methohexital
- Metoclopramide
- Metoprolol
- Metyrapone
- Metyrosine
- Minocycline
- Mipomersen
- Mirabegron
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Opiate Agonists
- Oritavancin
- Orphenadrine
- Oxycodone
- Oxymorphone
- Paliperidone
- Papaverine
- Paromomycin
- Paroxetine
- Peginterferon Alfa-2b
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Pimozide
- Pitolisant
- Plazomicin
- Pneumococcal Vaccine, Polyvalent
- Posaconazole
- Pramipexole
- Pramlintide
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Quetiapine
- Quinidine
- Ramelteon
- Rasagiline
- Remifentanil
- Rifabutin
- Rifampin
- Risperidone
- Ritonavir
- Rituximab; Hyaluronidase
- Rivastigmine
- Rolapitant
- Ropinirole
- Ropivacaine
- Rotigotine
- Safinamide
- Salsalate
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sincalide
- Sodium Bicarbonate
- Sodium Iodide
- Solifenacin
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sufentanil
- Sulfinpyrazone
- Suvorexant
- Tacrine
- Tamsulosin
- Tapentadol
- Tasimelteon
- Telaprevir
- Telotristat Ethyl
- Tetrabenazine
- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Thiopental
- Thioridazine
- Thiothixene
- Tizanidine
- tobacco
- Tobramycin
- Tolcapone
- Topiramate
- Tramadol
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trimethobenzamide
- Trimetrexate
- Trospium
- Vemurafenib
- Vigabatrin
- Vilazodone
- Warfarin
- Zaleplon
- Ziconotide
- Zidovudine, ZDV
- Ziprasidone
- Zolmitriptan
- Zolpidem