Acetaminophen and Diphenhydramine

Acetaminophen and Diphenhydramine Brand Names

Aceta-Gesic | Bayer PM | Excedrin PM | Excedrin PM Express | Goody’s PM | Mapap PM | Midol PM | Percogesic | Percogesic Extra Strength | Tylenol Cold | Tylenol Cold Nighttime | Tylenol Day/Night Pack | Tylenol PM Extra Strength | Tylenol PM Extra Strength Rapid Release | Tylenol Severe Allergy | Tylenol Sore Throat Nighttime

What is Acetaminophen and Diphenhydramine

Acetaminophen and diphenhydramine are used together in an oral preparation either to provide temporary relief of occasional headache or mild aches and pain in patients with insomnia (sleeplessness) or to provide temporary relief of the symptoms of allergic respiratory conditions.

Acetaminophen is a non-narcotic, non-salicylate analgesic with similar potency to NSAIDs. Diphenhydramine is a sedating antihistamine (H1-blocker) of the ethanolamine class with strong anticholinergic activity commonly used to block histaminic responses and to facilitate sleep.

Acetaminophen; diphenhydramine has a significant potential for toxicity in overdose secondary to acetaminophen-induced hepatotoxicity and diphenhydramine-induced CNS depression.

Use with caution in patients with pre-existing hepatic impairment and in others with conditions that may result in an increased susceptibility to or likelihood of overdose.

Indications

  1. allergic conjunctivitis
  2. allergic rhinitis
  3. headache
  4. insomnia
  5. mild pain
  6. musculoskeletal pain
  7. ocular pruritus
  8. rhinorrhea
  9. sneezing

For the treatment of symptoms associated with allergic rhinitis (hay fever) or other respiratory allergies, such as allergic conjunctivitis with or without ocular pruritus, rhinorrhea, sneezing, sore throat, and pruritus of the nose or throat

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agitation
  4. agranulocytosis
  5. anaphylactic shock
  6. anaphylactoid reactions
  7. angioedema
  8. anorexia
  9. appetite stimulation
  10. asthenia
  11. bleeding
  12. blurred vision
  13. confusion
  14. constipation
  15. cyanosis
  16. diarrhea
  17. dizziness
  18. drowsiness
  19. dysarthria
  20. elevated hepatic enzymes
  21. erythema
  22. exfoliative dermatitis
  23. fatigue
  24. fever
  25. GI bleeding
  26. headache
  27. hemolytic anemia
  28. hepatic encephalopathy
  29. hepatic necrosis
  30. hypoprothrombinemia
  31. hypotension
  32. insomnia
  33. interstitial nephritis
  34. irritability
  35. jaundice
  36. maculopapular rash
  37. methemoglobinemia
  38. mydriasis
  39. nausea
  40. ocular hypertension
  41. palpitations
  42. pancytopenia
  43. photosensitivity
  44. pruritus
  45. rash
  46. renal papillary necrosis
  47. renal tubular necrosis
  48. restlessness
  49. seizures
  50. sinus tachycardia
  51. thrombocytopenia
  52. thrombocytosis
  53. tolerance
  54. toxic epidermal necrolysis
  55. urinary retention
  56. urticaria
  57. vomiting
  58. weakness
  59. withdrawal
  60. xerophthalmia
  61. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acetaminophen hypersensitivity
  • alcoholism
  • anemia
  • bladder obstruction
  • bone marrow suppression
  • breast-feeding
  • bronchitis
  • cardiac disease
  • children
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • cystic fibrosis
  • driving or operating machinery
  • emphysema
  • ethanol intoxication
  • G6PD deficiency
  • geriatric
  • GI obstruction
  • hepatic disease
  • hepatitis
  • ileus
  • immunosuppression
  • infants
  • malnutrition
  • neonates
  • neutropenia
  • potential for overdose or poisoning
  • pregnancy
  • prostatic hypertrophy
  • renal disease
  • tobacco smoking
  • urinary retention
  • visual disturbance

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aldesleukin, IL-2
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amikacin
  • Aminoglycosides
  • Amlodipine; Celecoxib
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Antacids
  • Anticholinergics
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir; Cobicistat
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzphetamine
  • Bethanechol
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Busulfan
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capecitabine
  • Capsaicin; Metaxalone
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Celecoxib
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Charcoal
  • Chloroprocaine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Clobazam
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Dapsone
  • Daratumumab; Hyaluronidase
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dutasteride; Tamsulosin
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Eltrombopag
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Entacapone
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etomidate
  • Exenatide
  • Ezogabine
  • Fenofibric Acid
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Gentamicin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyprogesterone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Imatinib
  • Insulin Glargine; Lixisenatide
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ivacaftor
  • Kanamycin
  • Ketamine
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamotrigine
  • Lanthanum Carbonate
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lidocaine
  • Lidocaine; Prilocaine
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Lomitapide
  • Lopinavir; Ritonavir
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Luliconazole
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Magnesium Salicylate
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Methohexital
  • Metoclopramide
  • Metoprolol
  • Metyrapone
  • Metyrosine
  • Minocycline
  • Mipomersen
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Opiate Agonists
  • Oritavancin
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Papaverine
  • Paromomycin
  • Paroxetine
  • Peginterferon Alfa-2b
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Pimozide
  • Pitolisant
  • Plazomicin
  • Pneumococcal Vaccine, Polyvalent
  • Posaconazole
  • Pramipexole
  • Pramlintide
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Quinidine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Rifabutin
  • Rifampin
  • Risperidone
  • Ritonavir
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Rolapitant
  • Ropinirole
  • Ropivacaine
  • Rotigotine
  • Safinamide
  • Salsalate
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sincalide
  • Sodium Bicarbonate
  • Sodium Iodide
  • Solifenacin
  • St. John’s Wort, Hypericum perforatum
  • Streptomycin
  • Sufentanil
  • Sulfinpyrazone
  • Suvorexant
  • Tacrine
  • Tamsulosin
  • Tapentadol
  • Tasimelteon
  • Telaprevir
  • Telotristat Ethyl
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • tobacco
  • Tobramycin
  • Tolcapone
  • Topiramate
  • Tramadol
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trimetrexate
  • Trospium
  • Vemurafenib
  • Vigabatrin
  • Vilazodone
  • Warfarin
  • Zaleplon
  • Ziconotide
  • Zidovudine, ZDV
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856