Acetaminophen Brand Names
7T Gummy ES | Acephen | Aceta | Actamin | Adult Pain Relief | Anacin Aspirin Free | Apra | Children’s Acetaminophen | Children’s Pain & Fever | Comtrex Sore Throat Relief | ED-APAP | ElixSure Fever/Pain | Feverall | Genapap | Genebs | Goody’s Back & Body Pain | Infantaire | Infants’ Acetaminophen | LIQUID PAIN RELIEF | Little Fevers | Little Remedies Infant Fever + Pain Reliever | Mapap | Mapap Arthritis Pain | Mapap Infants | Mapap Junior | M-PAP | Nortemp | Ofirmev | Pain & Fever | Pain and Fever | PAIN RELIEF | PAIN RELIEF Extra Strength | Panadol | PediaCare Children’s Fever Reducer/Pain Reliever | PediaCare Children’s Smooth Metls Fever Reducer/Pain Reliever | PediaCare Infant’s Fever Reducer/Pain Reliever | Pediaphen | PHARBETOL | Q-Pap | Q-Pap Extra Strength | Silapap | Triaminic Fever Reducer and Pain Reliever | Triaminic Infant Fever Reducer and Pain Reliever | Tylenol | Tylenol 8 Hour | Tylenol Arthritis Pain | Tylenol Children’s | Tylenol Children’s Pain+Fever | Tylenol CrushableTablet | Tylenol Extra Strength | Tylenol Infants’ | Tylenol Infants Pain + Fever | Tylenol Junior Strength | Tylenol Sore Throat | XS No Aspirin | XS Pain Reliever
What is Acetaminophen
Acetaminophen (APAP, paracetamol) is a para-aminophenol analgesic and the active metabolite of phenacetin.
Due to the toxic effects of phenacetin at therapeutic doses and the availability of acetaminophen, phenacetin is no longer used.
Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function.
Acetaminophen was first used in clinical medicine in the 1890s. It is effective in the relief of both acute and chronic pain and may be preferred over NSAIDs due to fewer hematologic, gastrointestinal, and renal effects.
Acetaminophen is the preferred analgesic/antipyretic for patients in whom aspirin is contraindicated and in those with underlying renal disease for episodic, though not chronic, use.
Indications
- arthralgia
- dental pain
- dysmenorrhea
- fever
- headache
- migraine
- mild pain
- moderate pain
- musculoskeletal pain
- myalgia
- osteoarthritis
- severe pain
Side Effects
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anorexia
- anxiety
- constipation
- contact dermatitis
- diarrhea
- dyspnea
- elevated hepatic enzymes
- erythema
- exfoliative dermatitis
- fatigue
- fever
- headache
- hearing loss
- heart failure
- hemolysis
- hemolytic anemia
- hepatic encephalopathy
- hepatic failure
- hepatic necrosis
- hepatotoxicity
- hypertension
- hypoalbuminemia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- hypoprothrombinemia
- hypotension
- injection site reaction
- insomnia
- interstitial nephritis
- jaundice
- maculopapular rash
- malaise
- muscle cramps
- myocarditis
- nausea
- neutropenia
- oliguria
- pancytopenia
- peripheral edema
- pleural effusion
- pruritus
- pulmonary edema
- purpura
- renal failure (unspecified)
- renal papillary necrosis
- renal tubular necrosis
- rhabdomyolysis
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- trismus
- urticaria
- vomiting
- wheezing
Monitoring Parameters
- LFTs
- serum creatinine/BUN: in chronic use or acute toxicity
Contraindications
- acetaminophen hypersensitivity
- alcoholism
- bone marrow suppression
- breast-feeding
- children
- diabetes mellitus
- ethanol intoxication
- G6PD deficiency
- geriatric
- hepatic disease
- hepatitis
- hepatotoxicity
- hypertension
- hypovolemia
- immunosuppression
- infants
- infection
- malnutrition
- neonates
- neutropenia
- phenylketonuria
- potential for overdose or poisoning
- pregnancy
- renal disease
- renal failure
- renal impairment
- tobacco smoking
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Amobarbital
- Antacids
- Aprepitant, Fosaprepitant
- Articaine; Epinephrine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Busulfan
- Butabarbital
- Carbamazepine
- Charcoal
- Chloroprocaine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Dapsone
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Diflunisal
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eltrombopag
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Exenatide
- Hydantoins
- Hydroxyprogesterone
- Imatinib
- Insulin Glargine; Lixisenatide
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lanthanum Carbonate
- Lidocaine
- Lidocaine; Prilocaine
- Lixisenatide
- Lomitapide
- Lopinavir; Ritonavir
- Magnesium Salicylate
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Methohexital
- Metyrapone
- Mipomersen
- Mitotane
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentobarbital
- Phenobarbital
- Pneumococcal Vaccine, Polyvalent
- Posaconazole
- Pramlintide
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Rifabutin
- Rifampin
- Ritonavir
- Ropivacaine
- Salsalate
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- St. John’s Wort, Hypericum perforatum
- Sulfinpyrazone
- Telaprevir
- Telotristat Ethyl
- Tetracaine
- Thiopental
- Tizanidine
- tobacco
- Trimetrexate
- Vemurafenib
- Warfarin
- Zidovudine, ZDV
- Zolmitriptan