Acetaminophen Guaifenesin Phenylephrine

Acetaminophen Guaifenesin Phenylephrine Brand Names

Duratuss A | Mucinex Fast-Max | Mucinex Sinus-Max | Sudafed PE Head Congestion + Mucus | Sudafed PE Pressure + Pain + Mucus | Sudafed PE Triple Action | Theraflu Cold and Chest Congestion | Tylenol Cold Head Congestion Severe | Tylenol Sinus | Tylenol Sinus Congestions & Pain Severe Daytime | Tylenol Sinus Severe Congestion

What is Acetaminophen Guaifenesin Phenylephrine

Acetaminophen Guaifenesin Phenylephrine are used together to provide temporary relief from symptoms such as mild pain, cough, nasal congestion, headache, sore throat, and fever associated with the common cold or flu, hay fever or allergies, sinusitis, and eustachian tube congestion.

The combination is also used as adjunctive treatment of serious otitis media and for symptomatic relief of respiratory conditions associated with a dry, nonproductive cough and tenacious mucus plugs in the respiratory tract.

Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function. Acetaminophen is the preferred analgesic/antipyretic for patients in whom aspirin is contraindicated (e.g., those who have a history of gastric ulcer or a coagulation disorder).

In addition, acetaminophen has been recommended by the American Lung Association as the first line treatment for aches and pains associated with the flu.

Guaifenesin loosens and thins sputum and bronchial secretions to ease expectoration.

Guaifenesin is especially useful for dry, non-productive coughs which tend to injure the respiratory mucous membranes. Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Acetaminophen Guaifenesin Phenylephrine products are available without a prescription (OTC).

Indications

1. common cold
2. cough
3. fever
4. headache
5. mild pain
6. nasal congestion

For the temporary relief of common cold and flu symptoms such as fever, mild pain and aches, sore throat, headache, nasal congestion, sinus congestion and pressure; helps to loosen phlegm (mucus) and thin bronchial secretions to make cough more productive

Side Effects

1. abdominal pain
2. acute generalized exanthematous pustulosis (AGEP)
3. agranulocytosis
4. anaphylactic shock
5. anaphylactoid reactions
6. angina
7. angioedema
8. anxiety
9. arrhythmia exacerbation
10. blurred vision
11. bowel ischemia
12. colitis
13. contact dermatitis
14. diarrhea
15. dizziness
16. elevated hepatic enzymes
17. erythema
18. exfoliative dermatitis
19. fever
20. headache
21. hemolysis
22. hemolytic anemia
23. hepatic encephalopathy
24. hepatic failure
25. hepatic necrosis
26. hypertension
27. hypoprothrombinemia
28. insomnia
29. interstitial nephritis
30. intracranial bleeding
31. jaundice
32. maculopapular rash
33. methemoglobinemia
34. myocardial infarction
35. myocarditis
36. nausea
37. nephrolithiasis
38. neutropenia
39. ocular hypertension
40. oliguria
41. palpitations
42. pancytopenia
43. pruritus
44. psychosis
45. purpura
46. rash
47. renal failure (unspecified)
48. renal papillary necrosis
49. renal tubular necrosis
50. restlessness
51. seizures
52. sinus tachycardia
53. stroke
54. thrombocytopenia
55. thrombocytosis
56. toxic epidermal necrolysis
57. tremor
58. urticaria
59. ventricular tachycardia
60. vomiting

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acetaminophen hypersensitivity
• acute myocardial infarction
• alcoholism
• anemia
• angina
• asthma
• AV block
• bone marrow suppression
• bradycardia
• breast-feeding
• bronchitis
• bundle-branch block
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• coronary artery disease
• diabetes mellitus
• emphysema
• fever
• G6PD deficiency
• geriatric
• heart failure
• hepatic disease
• hepatitis
• hypertension
• hyperthyroidism
• immunosuppression
• infants
• infection
• labor
• MAOI therapy
• neonates
• neutropenia
• obstetric delivery
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• renal disease
• renal failure
• renal impairment
• tachycardia
• thyroid disease
• thyrotoxicosis
• tobacco smoking
• urinary retention

Interactions

• Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
• Acarbose
• Acebutolol
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• Acetaminophen; Butalbital
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