Acetaminophen and Caffeine

Acetaminophen and Caffeine Brand Name

Excedrin Mild Headache | Excedrin Quick Tabs | Excedrin Tension Headache | Excedrin Tension Headache Express | Goody’s Headache Relief

What is Acetaminophen and Caffeine

Acetaminophen; caffeine is an oral analgesic indicated for the relief of mild pain due to cold and flu, dental pain, headache, myalgia, osteoarthritis, or sore throat.

Caffeine is included to enhance analgesic efficacy.

Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function.

It is effective in the relief of both acute and chronic pain and may be preferred over nonsteroidal anti-inflammatory drugs (NSAIDs) in certain patients due to fewer hematologic, gastrointestinal, and renal effects.

Acetaminophen is the analgesic/antipyretic of choice for episodic use in patients with underlying renal disease; however, chronic use in this population is discouraged.

Acetaminophen has a history of safe and effective use; however, unintentional or intentional misuse of acetaminophen is the leading cause of acute hepatic failure in the U.S.

Indications

• dental pain
• headache
• mild pain
• myalgia
• osteoarthritis

For the relief of mild pain due to cold and flu, dental pain, headache, myalgia, osteoarthritis, or sore throat

Side Effects

1. acute generalized exanthematous pustulosis (AGEP)
2. agranulocytosis
3. anaphylactic shock
4. anaphylactoid reactions
5. anemia
6. angioedema
7. anorexia
8. anxiety
9. constipation
10. contact dermatitis
11. diarrhea
12. dyspepsia
13. elevated hepatic enzymes
14. erythema
15. exfoliative dermatitis
16. gastroesophageal reflux
17. headache
18. hearing loss
19. hemolysis
20. hemolytic anemia
21. hepatic encephalopathy
22. hepatic failure
23. hepatic necrosis
24. hepatotoxicity
25. hypercalciuria
26. hyperglycemia
27. hypoglycemia
28. hypoprothrombinemia
29. increased urinary frequency
30. insomnia
31. interstitial nephritis
32. irritability
33. jaundice
34. maculopapular rash
35. malaise
36. nausea
37. neutropenia
38. palpitations
39. pancytopenia
40. polyuria
41. purpura
42. rash
43. renal failure (unspecified)
44. renal papillary necrosis
45. renal tubular necrosis
46. rhabdomyolysis
47. seizures
48. sinus tachycardia
49. Stevens-Johnson syndrome
50. thrombocytopenia
51. thrombocytosis
52. toxic epidermal necrolysis
53. tremor
54. urticaria
55. vomiting
56. withdrawal

Monitoring Parameters

• LFTs
• serum creatinine/BUN: in chronic use or acute toxicity

Contraindications

• acetaminophen hypersensitivity
• alcoholism
• anxiety
• breast-feeding
• cardiac disease
• diabetes mellitus
• ethanol intoxication
• G6PD deficiency
• gastroesophageal reflux disease (GERD)
• geriatric
• hepatic disease
• hepatitis
• hepatotoxicity
• hyperthyroidism
• hypovolemia
• insomnia
• malnutrition
• potential for overdose or poisoning
• pregnancy
• renal disease
• renal failure
• renal impairment
• seizure disorder
• tachycardia
• tobacco smoking

Interactions

• Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Pseudoephedrine
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Adenosine
• Albuterol
• Albuterol; Ipratropium
• Amantadine
• Amiodarone
• Amobarbital
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Anagrelide
• Antacids
• Aprepitant, Fosaprepitant
• Arformoterol
• Armodafinil
• Articaine; Epinephrine
• Aspirin, ASA
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Aspirin, ASA; Omeprazole
• Aspirin, ASA; Oxycodone
• Aspirin, ASA; Pravastatin
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benzodiazepines
• Benzphetamine
• Beta-agonists
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Boceprevir
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide; Formoterol
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Bupropion
• Bupropion; Naltrexone
• Busulfan
• Butabarbital
• Caffeine
• Cannabidiol
• Capmatinib
• Carbamazepine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cetirizine; Pseudoephedrine
• Charcoal
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloroprocaine
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Cholestyramine
• Choline Salicylate; Magnesium Salicylate
• Cimetidine
• Ciprofloxacin
• Clozapine
• Codeine; Phenylephrine; Promethazine
• Dapsone
• Darifenacin
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Desloratadine; Pseudoephedrine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmethylphenidate
• Dextroamphetamine
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Diethylpropion
• Diflunisal
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Phenylephrine
• Dipyridamole
• Disulfiram
• Dobutamine
• Dopamine
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Dyphylline
• Dyphylline; Guaifenesin
• Echinacea
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eltrombopag
• Ephedrine
• Epinephrine
• Erythromycin
• Erythromycin; Sulfisoxazole
• Esketamine
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Exenatide
• Fesoterodine
• Fexofenadine; Pseudoephedrine
• Fluconazole
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• Formoterol
• Formoterol; Mometasone
• Givosiran
• Glycopyrrolate; Formoterol
• grapefruit juice
• Green Tea
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guaifenesin; Pseudoephedrine
• Hydantoins
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydroxyprogesterone
• Ibuprofen; Pseudoephedrine
• Imatinib
• Indacaterol
• Indacaterol; Glycopyrrolate
• Insulin Glargine; Lixisenatide
• Isavuconazonium
• Isocarboxazid
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isoproterenol
• Ketoconazole
• Ketoprofen
• Lamivudine, 3TC; Zidovudine, ZDV
• Lamotrigine
• Lanthanum Carbonate
• Levalbuterol
• Lidocaine
• Lidocaine; Prilocaine
• Linezolid
• Lisdexamfetamine
• Lithium
• Lixisenatide
• Lomitapide
• Lopinavir; Ritonavir
• Loratadine; Pseudoephedrine
• Magnesium Salicylate
• Melatonin
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Mestranol; Norethindrone
• Metaproterenol
• Methamphetamine
• Methohexital
• Methylphenidate
• Metyrapone
• Mexiletine
• Midodrine
• Mipomersen
• Mitotane
• Modafinil
• Monoamine oxidase inhibitors
• Naproxen; Pseudoephedrine
• Non-Ionic Contrast Media
• Norepinephrine
• Obeticholic Acid
• Olodaterol
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Oxybutynin
• Peginterferon Alfa-2b
• Pemoline
• Penicillin G Benzathine; Penicillin G Procaine
• Penicillin G Procaine
• Pentobarbital
• Phendimetrazine
• Phenelzine
• Phenobarbital
• Phentermine
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Pirbuterol
• Pneumococcal Vaccine, Polyvalent
• Posaconazole
• Pramlintide
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Procarbazine
• Pseudoephedrine
• Racepinephrine
• Ramelteon
• Rasagiline
• Regadenoson
• Rifabutin
• Rifampin
• Ritodrine
• Ritonavir
• Ropivacaine
• Rucaparib
• Salmeterol
• Salsalate
• Secobarbital
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Sodium Bicarbonate
• Sodium Oxybate
• Solifenacin
• Solriamfetol
• St. John’s Wort, Hypericum perforatum
• Sulfinpyrazone
• Suvorexant
• Tasimelteon
• Telaprevir
• Telotristat Ethyl
• Terbinafine
• Terbutaline
• Teriflunomide
• Tetracaine
• Theophylline, Aminophylline
• Thiabendazole
• Thiopental
• Tiotropium; Olodaterol
• Tizanidine
• tobacco
• Tolterodine
• Trandolapril; Verapamil
• Tranylcypromine
• Trimetrexate
• Umeclidinium; Vilanterol
• Vemurafenib
• Verapamil
• Warfarin
• Yohimbine
• Zaleplon
• Zidovudine, ZDV
• Zileuton
• Zolmitriptan
• Zolpidem