Acalabrutinib

Acalabrutinib Brand Name – CALQUENCE

What is Acalabrutinib

Acalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved for the treatment of mantle cell lymphoma in adult patients who have received at least 1 prior therapy and as a single-agent or in combination with obinutuzumab in adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma. 

Indications

  • chronic lymphocytic leukemia (CLL)
  • macroglobulinemia
  • mantle cell lymphoma (MCL)
  • small lymphocytic lymphoma (SLL)

Side Effects

  1. abdominal pain
  2. anemia
  3. arthralgia
  4. asthenia
  5. atrial fibrillation
  6. atrial flutter
  7. back pain
  8. bleeding
  9. bone pain
  10. constipation
  11. diarrhea
  12. diarrhea
  13. ecchymosis
  14. elevated hepatic enzymes
  15. epistaxis
  16. fatigue
  17. headache
  18. hematoma
  19. hemoptysis
  20. hepatitis B exacerbation
  21. hyperbilirubinemia
  22. hypertension
  23. hyperuricemia
  24. infection
  25. intracranial bleeding
  26. lethargy
  27. lymphocytosis
  28. menorrhagia
  29. musculoskeletal pain
  30. myalgia
  31. nausea
  32. nephrotoxicity
  33. neutropenia
  34. new primary malignancy
  35. petechiae
  36. pharyngitis
  37. progressive multifocal leukoencephalopathy
  38. rash
  39. sinusitis
  40. skin cancer
  41. thrombocytopenia
  42. tracheitis
  43. vomiting

Monitoring Parameters

  • CBC with differential
  • ECG
  • LFTs
  • pregnancy testing
  • skin cancer screening exam

Contraindications

  • anemia
  • anticoagulant therapy
  • bleeding
  • breast-feeding
  • cardiac arrhythmias
  • contraception requirements
  • dental work
  • fungal infection
  • geriatric
  • hepatic disease
  • hepatitis B exacerbation
  • hypertension
  • infection
  • intracranial bleeding
  • neutropenia
  • new primary malignancy
  • pregnancy
  • pregnancy testing
  • progressive multifocal leukoencephalopathy
  • reproductive risk
  • sunlight (UV) exposure
  • surgery
  • thrombocytopenia
  • viral infection

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Alpelisib
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Antacids
  • Apalutamide
  • Aprepitant, Fosaprepitant
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Brigatinib
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Carbamazepine
  • Ceritinib
  • Chloramphenicol
  • Cimetidine
  • Ciprofloxacin
  • Clarithromycin
  • Cobicistat
  • Conivaptan
  • Crizotinib
  • Cyclosporine
  • Danazol
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Dexlansoprazole
  • Diltiazem
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Dronedarone
  • Duvelisib
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Enzalutamide
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Famotidine
  • Famotidine; Ibuprofen
  • Fedratinib
  • Fluconazole
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Glecaprevir; Pibrentasvir
  • grapefruit juice
  • H2-blockers
  • Idelalisib
  • Imatinib
  • Indinavir
  • Irinotecan
  • Irinotecan Liposomal
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Ledipasvir; Sofosbuvir
  • Lefamulin
  • Letermovir
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Magnesium Hydroxide
  • Mephobarbital
  • Methotrexate
  • Mifepristone
  • Mitotane
  • Mitoxantrone
  • Nefazodone
  • Nelfinavir
  • Netupitant, Fosnetupitant; Palonosetron
  • Nicardipine
  • Nilotinib
  • Nizatidine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ozanimod
  • Pantoprazole
  • Pazopanib
  • Phenobarbital
  • Phenytoin
  • Posaconazole
  • Primidone
  • Quinine
  • Rabeprazole
  • Ranitidine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Rimegepant
  • Ritonavir
  • Rosuvastatin
  • Saquinavir
  • Sodium Bicarbonate
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • St. John’s Wort, Hypericum perforatum
  • Sulfasalazine
  • Talazoparib
  • Telithromycin
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Tipranavir
  • Topotecan
  • Trandolapril; Verapamil
  • Tucatinib
  • Ubrogepant
  • Verapamil
  • Voriconazole
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