Acamprosate

Acamprosate Brand Name – Acamprosate

What is Acamprosate

Acamprosate is used as an adjunct to comprehensive management programs and psychosocial support to help alcoholics maintain abstinence following ethanol withdrawal.

Acamprosate is structurally related to endogenous homotaurine, a structural analogue of gamma-aminobutyric acid (GABA) and the amino acid taurine.

The FDA approved acamprosate in July 2004.

Indications

  • alcohol dependence

Side Effects

  1. abdominal pain
  2. acne vulgaris
  3. agitation
  4. alopecia
  5. amblyopia
  6. amnesia
  7. anemia
  8. angina
  9. anorexia
  10. anxiety
  11. appetite stimulation
  12. arthralgia
  13. ascites
  14. asthenia
  15. atopic dermatitis
  16. back pain
  17. bone fractures
  18. bronchospasm
  19. cardiomyopathy
  20. chest pain (unspecified)
  21. chills
  22. cholecystitis
  23. cirrhosis
  24. colitis
  25. confusion
  26. constipation
  27. cough
  28. depression
  29. diabetes mellitus
  30. diarrhea
  31. diplopia
  32. dizziness
  33. drowsiness
  34. dysgeusia
  35. dyspepsia
  36. dysphagia
  37. dyspnea
  38. ecchymosis
  39. ejaculation dysfunction
  40. elevated hepatic enzymes
  41. encephalopathy
  42. eosinophilia
  43. epistaxis
  44. eructation
  45. esophagitis
  46. exfoliative dermatitis
  47. fever
  48. flatulence
  49. gastritis
  50. GI bleeding
  51. goiter
  52. gout
  53. hallucinations
  54. headache
  55. hearing loss
  56. heart failure
  57. hematemesis
  58. hematuria
  59. hepatitis
  60. hostility
  61. hyperbilirubinemia
  62. hyperesthesia
  63. hyperglycemia
  64. hyperhidrosis
  65. hyperkinesis
  66. hypersalivation
  67. hypertension
  68. hyperuricemia
  69. hyponatremia
  70. hypotension
  71. hypothyroidism
  72. impotence (erectile dysfunction)
  73. increased urinary frequency
  74. infection
  75. influenza
  76. insomnia
  77. leukopenia
  78. libido decrease
  79. libido increase
  80. lymphadenopathy
  81. lymphocytosis
  82. maculopapular rash
  83. malaise
  84. mania
  85. melena
  86. menorrhagia
  87. migraine
  88. muscle cramps
  89. myalgia
  90. myocardial infarction
  91. myopathy
  92. nausea
  93. nephrolithiasis
  94. neuropathic pain
  95. nocturia
  96. oral ulceration
  97. orthostatic hypotension
  98. palpitations
  99. pancreatitis
  100. paranoia
  101. paresthesias
  102. peptic ulcer
  103. peripheral edema
  104. peripheral vasodilation
  105. pharyngitis
  106. phlebitis
  107. photophobia
  108. photosensitivity
  109. polyuria
  110. pruritus
  111. psoriasis
  112. psychosis
  113. pulmonary embolism
  114. rash
  115. renal failure (unspecified)
  116. rhinitis
  117. seizures
  118. sinus tachycardia
  119. suicidal ideation
  120. syncope
  121. thrombocytopenia
  122. tinnitus
  123. torticollis
  124. tremor
  125. urinary incontinence
  126. urinary urgency
  127. urticaria
  128. vaginitis
  129. vertigo
  130. visual impairment
  131. vomiting
  132. weight gain
  133. weight loss
  134. withdrawal
  135. xerosis

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • children
  • depression
  • driving or operating machinery
  • ethanol intoxication
  • geriatric
  • infants
  • neonates
  • pregnancy
  • renal failure
  • renal impairment
  • suicidal ideation
  • sulfite hypersensitivity

Interactions

  • Bupropion; Naltrexone
  • Naltrexone
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