Acamprosate Brand Name – Acamprosate
What is Acamprosate
Acamprosate is used as an adjunct to comprehensive management programs and psychosocial support to help alcoholics maintain abstinence following ethanol withdrawal.
Acamprosate is structurally related to endogenous homotaurine, a structural analogue of gamma-aminobutyric acid (GABA) and the amino acid taurine.
The FDA approved acamprosate in July 2004.
Indications
- alcohol dependence
Side Effects
- abdominal pain
- acne vulgaris
- agitation
- alopecia
- amblyopia
- amnesia
- anemia
- angina
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- ascites
- asthenia
- atopic dermatitis
- back pain
- bone fractures
- bronchospasm
- cardiomyopathy
- chest pain (unspecified)
- chills
- cholecystitis
- cirrhosis
- colitis
- confusion
- constipation
- cough
- depression
- diabetes mellitus
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- ecchymosis
- ejaculation dysfunction
- elevated hepatic enzymes
- encephalopathy
- eosinophilia
- epistaxis
- eructation
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- gastritis
- GI bleeding
- goiter
- gout
- hallucinations
- headache
- hearing loss
- heart failure
- hematemesis
- hematuria
- hepatitis
- hostility
- hyperbilirubinemia
- hyperesthesia
- hyperglycemia
- hyperhidrosis
- hyperkinesis
- hypersalivation
- hypertension
- hyperuricemia
- hyponatremia
- hypotension
- hypothyroidism
- impotence (erectile dysfunction)
- increased urinary frequency
- infection
- influenza
- insomnia
- leukopenia
- libido decrease
- libido increase
- lymphadenopathy
- lymphocytosis
- maculopapular rash
- malaise
- mania
- melena
- menorrhagia
- migraine
- muscle cramps
- myalgia
- myocardial infarction
- myopathy
- nausea
- nephrolithiasis
- neuropathic pain
- nocturia
- oral ulceration
- orthostatic hypotension
- palpitations
- pancreatitis
- paranoia
- paresthesias
- peptic ulcer
- peripheral edema
- peripheral vasodilation
- pharyngitis
- phlebitis
- photophobia
- photosensitivity
- polyuria
- pruritus
- psoriasis
- psychosis
- pulmonary embolism
- rash
- renal failure (unspecified)
- rhinitis
- seizures
- sinus tachycardia
- suicidal ideation
- syncope
- thrombocytopenia
- tinnitus
- torticollis
- tremor
- urinary incontinence
- urinary urgency
- urticaria
- vaginitis
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- withdrawal
- xerosis
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- depression
- driving or operating machinery
- ethanol intoxication
- geriatric
- infants
- neonates
- pregnancy
- renal failure
- renal impairment
- suicidal ideation
- sulfite hypersensitivity
Interactions
- Bupropion; Naltrexone
- Naltrexone
