AbobotulinumtoxinA

AbobotulinumtoxinA Brand Name – Dysport

What is AbobotulinumtoxinA

AbobotulinumtoxinA is a botulinum toxin type A-hemagglutinin complex approved for the treatment of cervical dystonia and glabellar lines in adults, and for the treatment of spasticity in both pediatric and adult patients.

Like other botulinum toxin type A formulations, abobotulinumtoxinA is an intramuscular toxin produced from fermentation of Clostridium botulinum type A.

Indications

  1. blepharospasm
  2. cervical dystonia
  3. facial wrinkles
  4. hyperhidrosis
  5. spasticity

Side Effects

  1. anaphylactoid reactions
  2. antibody formation
  3. arthralgia
  4. asthenia
  5. back pain
  6. blurred vision
  7. constipation
  8. contact dermatitis
  9. cough
  10. depression
  11. diarrhea
  12. diplopia
  13. distant spread of toxin effects
  14. dizziness
  15. dysarthria
  16. dysphagia
  17. dysphonia
  18. dyspnea
  19. edema
  20. elevated hepatic enzymes
  21. erythema
  22. fatigue
  23. fever
  24. headache
  25. hematuria
  26. hyperglycemia
  27. hypertension
  28. hypertonia
  29. hypertriglyceridemia
  30. hypoesthesia
  31. infection
  32. influenza
  33. injection site reaction
  34. insomnia
  35. musculoskeletal pain
  36. myalgia
  37. myasthenia
  38. nausea
  39. ocular irritation
  40. ocular pain
  41. ocular pruritus
  42. paresis
  43. peripheral edema
  44. pharyngitis
  45. photophobia
  46. ptosis
  47. respiratory arrest
  48. seizures
  49. serum sickness
  50. sinusitis
  51. syncope
  52. urinary incontinence
  53. urticaria
  54. vertigo
  55. visual impairment
  56. weakness
  57. xerophthalmia
  58. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • albumin hypersensitivity
  • amyotrophic lateral sclerosis (ALS)
  • autonomic neuropathy
  • breast-feeding
  • cardiac disease
  • cerebral palsy
  • children
  • diabetes mellitus
  • distant spread of toxin effects
  • driving or operating machinery
  • dysphagia
  • geriatric
  • infection
  • inflammation
  • milk protein hypersensitivity
  • myasthenia gravis
  • myopathy
  • neuromuscular disease
  • pregnancy
  • requires an experienced clinician
  • respiratory insufficiency
  • surgery
  • viral infection
  • visual impairment

Interactions

  • Amikacin
  • Anticholinergics
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Atracurium
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Baclofen
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Capreomycin
  • Capsaicin; Metaxalone
  • Carisoprodol
  • Chlordiazepoxide; Clidinium
  • Chlorzoxazone
  • Cisatracurium
  • Cyclobenzaprine
  • Dantrolene
  • Dicyclomine
  • Doxacurium
  • Flavoxate
  • Gentamicin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Homatropine; Hydrocodone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indacaterol; Glycopyrrolate
  • Kanamycin
  • Mepenzolate
  • Metaxalone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Mivacurium
  • Neomycin
  • Neuromuscular blockers
  • Orphenadrine
  • Oxybutynin
  • Pancuronium
  • Paromomycin
  • Polymyxins
  • Propantheline
  • Rapacuronium
  • Rocuronium
  • Scopolamine
  • Skeletal Muscle Relaxants
  • Solifenacin
  • Streptomycin
  • Succinylcholine
  • Tapentadol
  • Tobramycin
  • Trihexyphenidyl
  • Trospium
  • Tubocurarine
  • Vecuronium
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