AbobotulinumtoxinA Brand Name – Dysport
What is AbobotulinumtoxinA
AbobotulinumtoxinA is a botulinum toxin type A-hemagglutinin complex approved for the treatment of cervical dystonia and glabellar lines in adults, and for the treatment of spasticity in both pediatric and adult patients.
Like other botulinum toxin type A formulations, abobotulinumtoxinA is an intramuscular toxin produced from fermentation of Clostridium botulinum type A.
Indications
- blepharospasm
- cervical dystonia
- facial wrinkles
- hyperhidrosis
- spasticity
Side Effects
- anaphylactoid reactions
- antibody formation
- arthralgia
- asthenia
- back pain
- blurred vision
- constipation
- contact dermatitis
- cough
- depression
- diarrhea
- diplopia
- distant spread of toxin effects
- dizziness
- dysarthria
- dysphagia
- dysphonia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- headache
- hematuria
- hyperglycemia
- hypertension
- hypertonia
- hypertriglyceridemia
- hypoesthesia
- infection
- influenza
- injection site reaction
- insomnia
- musculoskeletal pain
- myalgia
- myasthenia
- nausea
- ocular irritation
- ocular pain
- ocular pruritus
- paresis
- peripheral edema
- pharyngitis
- photophobia
- ptosis
- respiratory arrest
- seizures
- serum sickness
- sinusitis
- syncope
- urinary incontinence
- urticaria
- vertigo
- visual impairment
- weakness
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- albumin hypersensitivity
- amyotrophic lateral sclerosis (ALS)
- autonomic neuropathy
- breast-feeding
- cardiac disease
- cerebral palsy
- children
- diabetes mellitus
- distant spread of toxin effects
- driving or operating machinery
- dysphagia
- geriatric
- infection
- inflammation
- milk protein hypersensitivity
- myasthenia gravis
- myopathy
- neuromuscular disease
- pregnancy
- requires an experienced clinician
- respiratory insufficiency
- surgery
- viral infection
- visual impairment
Interactions
- Amikacin
- Anticholinergics
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Capreomycin
- Capsaicin; Metaxalone
- Carisoprodol
- Chlordiazepoxide; Clidinium
- Chlorzoxazone
- Cisatracurium
- Cyclobenzaprine
- Dantrolene
- Dicyclomine
- Doxacurium
- Flavoxate
- Gentamicin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indacaterol; Glycopyrrolate
- Kanamycin
- Mepenzolate
- Metaxalone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Mivacurium
- Neomycin
- Neuromuscular blockers
- Orphenadrine
- Oxybutynin
- Pancuronium
- Paromomycin
- Polymyxins
- Propantheline
- Rapacuronium
- Rocuronium
- Scopolamine
- Skeletal Muscle Relaxants
- Solifenacin
- Streptomycin
- Succinylcholine
- Tapentadol
- Tobramycin
- Trihexyphenidyl
- Trospium
- Tubocurarine
- Vecuronium
