What is Tafamidis

Tafamidis, a selective transthyretin (TTR) stabilizer, is indicated for the treatment of the cardiomyopathy of wild type or hereditary transthyretin-mediated amyloidosis in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization.

A significant reduction in all-cause mortality and cardiovascular-related hospitalization occurred with tafamidis therapy (20 mg once daily and 80 mg once daily) compared to placebo in a randomized, multicenter, international study that enrolled 441 patients with wild type or hereditary transthyretin-mediated amyloid cardiomyopathy (p = 0.0006).

Tafamidis was associated with a 30% relative reduction in the risk of death and a 32% decrease in risk of cardiovascular-related hospitalization compared to placebo. Incidence of adverse effects was similar between tafamidis and placebo.

Brand Names

  • Vyndamax
  • Vyndaqel


  • transthyretin amyloid cardiomyopathy

For the treatment of wild type or hereditary transthyretin amyloid cardiomyopathy in adults to reduce cardiovascular mortality and cardiovascular-related hospitalization

Side Effects

In a clinical trial involving 441 patients with transthyretin amyloid cardiomyopathy, the incidences of adverse reactions and adverse reaction-related study discontinuation were similar between patients that received tafamidis 20 mg once daily, tafamidis 80 mg (four 20 mg capsules), and placebo.

Monitoring Parameters

  • laboratory monitoring not necessary


  • breast-feeding
  • contraception requirements
  • pregnancy


  • Abacavir; Dolutegravir; Lamivudine
  • Alpelisib
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Emtricitabine; Tenofovir alafenamide
  • Emtricitabine; Tenofovir disoproxil fumarate
  • Glecaprevir; Pibrentasvir
  • Glyburide
  • Glyburide; Metformin
  • Imatinib
  • Irinotecan
  • Irinotecan Liposomal
  • Lamivudine; Tenofovir Disoproxil Fumarate
  • Ledipasvir; Sofosbuvir
  • Methotrexate
  • Ombitasvir; Paritaprevir; Ritonavir
  • Ozanimod
  • Pazopanib
  • Prazosin
  • Rimegepant
  • Rosuvastatin
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sulfasalazine
  • Talazoparib
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Topotecan
  • Ubrogepant
  • Vemurafenib

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top