Abemaciclib Brand Name – VERZENIO
What is Abemaciclib
Abemaciclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6).
It is approved in combination with fulvestrant for the treatment of women with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy.
Additionally, it is approved as monotherapy for women and men with HR-positive, HER2-negative advanced or metastatic breast cancer with disease progression following endocrine therapy and prior chemotherapy in the metastatic setting.
Diarrhea is the most common adverse reaction; instruct patients to begin antidiarrheal therapy at the first sign of loose stools. Neutropenia, hepatotoxicity, and thromboembolism may also occur.
Indications
- breast cancer
For the treatment of hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer
for initial endocrine-based treatment of HR-positive, HER2-negative advanced or metastatic breast cancer, in combination with an aromatase inhibitor
Side Effects
- abdominal pain
- abdominal pain
- alopecia
- anemia
- anemia
- anorexia
- anorexia
- arthralgia
- asthenia
- asthenia
- bone fractures
- conjunctivitis
- constipation
- constipation
- cough
- dehydration
- dehydration
- diarrhea
- diarrhea
- dizziness
- dizziness
- dysgeusia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- fatigue
- fever
- fever
- headache
- headache
- hepatotoxicity
- infection
- infection
- influenza
- interstitial lung disease
- interstitial lung disease
- leukopenia
- leukopenia
- lymphopenia
- nausea
- nausea
- neutropenia
- neutropenia
- peripheral edema
- pharyngitis
- pneumonitis
- pneumonitis
- pruritus
- pulmonary embolism
- pulmonary fibrosis
- QT prolongation
- rash
- rash
- renal failure (unspecified)
- sinusitis
- stomatitis
- stomatitis
- stroke
- thrombocytopenia
- thrombocytopenia
- thromboembolism
- thrombosis
- vomiting
- vomiting
- weight loss
- weight loss
- xerostomia
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
Contraindications
- breast-feeding
- chronic lung disease (CLD)
- contraception requirements
- diarrhea
- hepatic disease
- hepatotoxicity
- infertility
- neutropenia
- pneumonitis
- pregnancy
- pregnancy testing
- reproductive risk
- thromboembolic disease
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Brigatinib
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Colony Stimulating Factors
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Fedratinib
- Filgrastim, G-CSF
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Mephobarbital
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Pegfilgrastim
- Pentobarbital
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Ritonavir
- Saquinavir
- Secobarbital
- St. John’s Wort, Hypericum perforatum
- Telithromycin
- Thiopental
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Verapamil
- Voriconazole