Abciximab

Abciximab Brand Name – ReoPro

What is Abciximab

Abciximab was the first FDA-approved platelet glycoprotein IIb/IIIa inhibitor. It is the Fab fragment of the chimeric monoclonal antibody 7E3.

The substitution of human IgG for the murine IgG molecule produces a Fab fragment that causes fewer allergic and thrombocytopenic complications.

Abciximab was FDA-approved in December 1994. In November 1997, the FDA expanded the indications for abciximab to a broader range of patients undergoing PCI, including those with unstable angina not responding to conventional therapy.

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. antibody formation
  7. anxiety
  8. asthenia
  9. AV block
  10. back pain
  11. bleeding
  12. bleeding
  13. bradycardia
  14. bronchospasm
  15. bullous rash
  16. chest pain (unspecified)
  17. coma
  18. confusion
  19. diabetes mellitus
  20. diarrhea
  21. diplopia
  22. dizziness
  23. dyspepsia
  24. dysuria
  25. gastroesophageal reflux
  26. GI bleeding
  27. headache
  28. hematemesis
  29. hematuria
  30. hemoptysis
  31. hyperhidrosis
  32. hyperkalemia
  33. hypertonia
  34. hypoesthesia
  35. hypotension
  36. ileus
  37. increased urinary frequency
  38. injection site reaction
  39. intracranial bleeding
  40. leukocytosis
  41. myalgia
  42. nausea
  43. pallor
  44. palpitations
  45. peripheral edema
  46. petechiae
  47. phlebitis
  48. platelet dysfunction
  49. pleural effusion
  50. prolonged bleeding time
  51. prostatitis
  52. pruritus
  53. pulmonary embolism
  54. retroperitoneal bleeding
  55. stroke
  56. thrombocytopenia
  57. thrombocytopenia
  58. thromboembolism
  59. urinary incontinence
  60. urinary retention
  61. ventricular tachycardia
  62. visual impairment
  63. vomiting
  64. xerostomia

Monitoring Parameters

  • activated partial thromboplastin time (APTT)
  • clotting time
  • hemoglobin/hematocrit
  • platelet count
  • thrombin time

Contraindications

  • abciximab hypersensitivity
  • aneurysm
  • anticoagulant therapy
  • arteriovenous malformation
  • bleeding
  • breast-feeding
  • children
  • coagulopathy
  • dextran therapy
  • geriatric
  • GI bleeding
  • human anti-chimeric antibody (HACA)
  • human anti-murine antibody (HAMA)
  • hypertension
  • infants
  • intracranial mass
  • intramuscular injections
  • murine protein hypersensitivity
  • pregnancy
  • stroke
  • surgery
  • thrombocytopenia
  • thrombolytic therapy
  • trauma
  • vasculitis
  • venipuncture

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Ado-Trastuzumab emtansine
  • ADP receptor antagonists
  • Altretamine
  • Aminolevulinic Acid
  • Anagrelide
  • Antimetabolites
  • Antithrombin III
  • Antithymocyte Globulin
  • Apixaban
  • Argatroban
  • Arsenic Trioxide
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Betrixaban
  • Bexarotene
  • Bivalirudin
  • Chlorambucil
  • Cilostazol
  • Cladribine
  • Clofarabine
  • Collagenase
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Danazol
  • Dasatinib
  • Defibrotide
  • Denileukin Diftitox
  • Desirudin
  • Desvenlafaxine
  • Dipyridamole
  • Drotrecogin Alfa
  • Duloxetine
  • Edoxaban
  • Enoxaparin
  • Estramustine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fludarabine
  • Folate analogs
  • Fondaparinux
  • Garlic, Allium sativum
  • Ginger, Zingiber officinale
  • Ginkgo, Ginkgo biloba
  • Green Tea
  • Heparin
  • Ibritumomab Tiuxetan
  • Ibrutinib
  • Icosapent ethyl
  • Iloprost
  • Imatinib
  • Inotersen
  • Intravenous Lipid Emulsions
  • Lepirudin
  • Levomilnacipran
  • Lomustine, CCNU
  • Mercaptopurine, 6-MP
  • Methoxsalen
  • Methylsulfonylmethane, MSM
  • Milnacipran
  • Mycophenolate
  • Nelarabine
  • Nonsteroidal antiinflammatory drugs
  • Obinutuzumab
  • Pegaspargase
  • Pentosan
  • Pentostatin
  • Pentoxifylline
  • Phentermine; Topiramate
  • Photosensitizing agents (topical)
  • Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
  • Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
  • Purine analogs
  • Rivaroxaban
  • Selective serotonin reuptake inhibitors
  • Selumetinib
  • Sodium Hyaluronate, Hyaluronic Acid
  • Sulfinpyrazone
  • Thioguanine, 6-TG
  • Thrombolytic Agents
  • Tinzaparin
  • Tipranavir
  • Topiramate
  • Trazodone
  • Treprostinil
  • Tretinoin, ATRA
  • Venlafaxine
  • Verteporfin
  • Vilazodone
  • Vorapaxar
  • Vorinostat
  • Vortioxetine
  • Warfarin
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