Abatacept

Abatacept Brand Name

Orencia

What is Abatacept

Abatacept is a fully human recombinant fusion protein categorized as a costimulatory or second-signal blocker of T cell activation. Abatacept disrupts the activation pathway of T cells causing a disturbance in key mechanisms of inflammation.

Abatacept has been shown useful for a variety of inflammatory conditions, and is given intravenously or by subcutaneous injection.

The drug is used in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in adult patients not adequately responding to tumor necrosis factor (TNF) antagonists; the drug may be used as monotherapy or can be used with non-biologic DMARDs.

Indications

  • polyarticular juvenile idiopathic arthritis
  • psoriatic arthritis
  • rheumatoid arthritis

For the treatment of moderate to severe rheumatoid arthritis to reduce signs and symptoms of the disease, to induce a major clinical response, to inhibit the progression of structural damage, and to improve physical function

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. antibody formation
  5. back pain
  6. cough
  7. diarrhea
  8. dizziness
  9. dyspepsia
  10. dyspnea
  11. erythema
  12. fever
  13. flushing
  14. headache
  15. hematoma
  16. hypertension
  17. hypotension
  18. infection
  19. influenza
  20. infusion-related reactions
  21. nausea
  22. new primary malignancy
  23. pharyngitis
  24. pruritus
  25. psoriasis
  26. rash
  27. rhinitis
  28. sinusitis
  29. urticaria
  30. vasculitis
  31. wheezing

Monitoring Parameters

  • hepatitis B serology
  • tuberculin skin test

Contraindications

  • agranulocytosis
  • asthma
  • bone marrow suppression
  • breast-feeding
  • children
  • chronic obstructive pulmonary disease (COPD)
  • corticosteroid therapy
  • cystic fibrosis
  • diabetes mellitus
  • emphysema
  • geriatric
  • hepatitis
  • hyperglycemia
  • immunosuppression
  • infants
  • infection
  • maltose hypersensitivity
  • neoplastic disease
  • pregnancy
  • respiratory infection
  • sepsis
  • tobacco smoking
  • tuberculosis
  • vaccination

Interactions

  • Adalimumab
  • Anakinra
  • Antithymocyte Globulin
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azathioprine
  • Baricitinib
  • Basiliximab
  • Certolizumab pegol
  • Corticosteroids
  • Cyclophosphamide
  • Cyclosporine
  • Efalizumab
  • Etanercept
  • Golimumab
  • Halothane
  • Infliximab
  • Live Vaccines
  • Muromonab-CD3
  • Rituximab
  • Rituximab; Hyaluronidase
  • Sarilumab
  • Scopolamine
  • Tocilizumab
  • Tofacitinib
  • Tumor Necrosis Factor modifiers
  • Upadacitinib
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