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Abatacept Brand Name
Orencia
What is Abatacept
Abatacept is a fully human recombinant fusion protein categorized as a costimulatory or second-signal blocker of T cell activation. Abatacept disrupts the activation pathway of T cells causing a disturbance in key mechanisms of inflammation.
Abatacept has been shown useful for a variety of inflammatory conditions, and is given intravenously or by subcutaneous injection.
The drug is used in rheumatoid arthritis (RA) and psoriatic arthritis (PsA) in adult patients not adequately responding to tumor necrosis factor (TNF) antagonists; the drug may be used as monotherapy or can be used with non-biologic DMARDs.
Indications
- polyarticular juvenile idiopathic arthritis
- psoriatic arthritis
- rheumatoid arthritis
For the treatment of moderate to severe rheumatoid arthritis to reduce signs and symptoms of the disease, to induce a major clinical response, to inhibit the progression of structural damage, and to improve physical function
Side Effects
- abdominal pain
- anaphylactic shock
- anaphylactoid reactions
- antibody formation
- back pain
- cough
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- erythema
- fever
- flushing
- headache
- hematoma
- hypertension
- hypotension
- infection
- influenza
- infusion-related reactions
- nausea
- new primary malignancy
- pharyngitis
- pruritus
- psoriasis
- rash
- rhinitis
- sinusitis
- urticaria
- vasculitis
- wheezing
Monitoring Parameters
- hepatitis B serology
- tuberculin skin test
Contraindications
- agranulocytosis
- asthma
- bone marrow suppression
- breast-feeding
- children
- chronic obstructive pulmonary disease (COPD)
- corticosteroid therapy
- cystic fibrosis
- diabetes mellitus
- emphysema
- geriatric
- hepatitis
- hyperglycemia
- immunosuppression
- infants
- infection
- maltose hypersensitivity
- neoplastic disease
- pregnancy
- respiratory infection
- sepsis
- tobacco smoking
- tuberculosis
- vaccination
Interactions
- Adalimumab
- Anakinra
- Antithymocyte Globulin
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azathioprine
- Baricitinib
- Basiliximab
- Certolizumab pegol
- Corticosteroids
- Cyclophosphamide
- Cyclosporine
- Efalizumab
- Etanercept
- Golimumab
- Halothane
- Infliximab
- Live Vaccines
- Muromonab-CD3
- Rituximab
- Rituximab; Hyaluronidase
- Sarilumab
- Scopolamine
- Tocilizumab
- Tofacitinib
- Tumor Necrosis Factor modifiers
- Upadacitinib
