Tiludronate

What is Tiludronate

NOTE: This drug is discontinued in the U.S.

Tiludronate was a bisphosphonate used in the treatment of Paget’s disease.

Guidelines for Paget’s disease preferentially recommend other potent bisphosphonates for this indication.

Tiludronate was never approved in the U.S. for osteoporosis treatment or prevention as studies failed to produce convincing evidence of efficacy for reducing fracture risk in these patients versus placebo.

Tiludronate was approved by the FDA in 1997, but was discontinued from marketing in the U.S. in 2011.

Brand Name

Skelid

Indications

  • Paget’s disease

For the treatment of Paget’s disease

Side Effects

  1. abdominal pain
  2. anorexia
  3. anxiety
  4. arthralgia
  5. asthenia
  6. atrial fibrillation
  7. back pain
  8. bone fractures
  9. bone pain
  10. cataracts
  11. chest pain (unspecified)
  12. conjunctivitis
  13. constipation
  14. cough
  15. diarrhea
  16. dizziness
  17. dyspepsia
  18. dysphagia
  19. edema
  20. esophageal ulceration
  21. esophagitis
  22. fatigue
  23. flatulence
  24. flushing
  25. gastritis
  26. headache
  27. hyperhidrosis
  28. hypertension
  29. infection
  30. insomnia
  31. myalgia
  32. nausea
  33. ocular inflammation
  34. ocular pain
  35. odynophagia
  36. osteonecrosis
  37. paresthesias
  38. peptic ulcer
  39. peripheral edema
  40. pharyngitis
  41. pruritus
  42. pyrosis (heartburn)
  43. rash
  44. rhinitis
  45. sinusitis
  46. Stevens-Johnson syndrome
  47. syncope
  48. uveitis
  49. vertigo
  50. visual impairment
  51. vomiting
  52. xerostomia

Monitoring Parameters

  • serum 25(OH)hydroxyvitamin D concentrations
  • serum alkaline phosphatase
  • serum calcium
  • serum creatinine/BUN
  • serum phosphate

Contraindications

  • achalasia
  • anemia
  • breast-feeding
  • chemotherapy
  • children
  • coagulopathy
  • corticosteroid therapy
  • dental disease
  • dental work
  • dysphagia
  • esophageal stricture
  • esophagitis
  • gastritis
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI disease
  • hiatal hernia
  • hyperparathyroidism
  • hypocalcemia
  • inability to stand or sit upright
  • infection
  • phosphonate hypersensitivity
  • pregnancy
  • renal failure
  • renal impairment
  • vitamin D deficiency

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amlodipine; Celecoxib
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Celecoxib
  • Chromium
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diflunisal
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Esomeprazole; Naproxen
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Etodolac
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Flurbiprofen
  • food
  • Hetastarch; Dextrose; Electrolytes
  • Hydrocodone; Ibuprofen
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Indomethacin
  • Iron
  • Iron Salts
  • Ketoprofen
  • Ketorolac
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Magnesium
  • Magnesium Citrate
  • Magnesium Salts
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Meloxicam
  • Nabumetone
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nonsteroidal antiinflammatory drugs
  • Omeprazole; Sodium Bicarbonate
  • Oxaprozin
  • Piroxicam
  • Polycarbophil
  • Polysaccharide-Iron Complex
  • Rofecoxib
  • Sodium Bicarbonate
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sulindac
  • Tolmetin
  • Valdecoxib
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