Symptoms of primary Sjogrens Syndrome

Symptoms of primary Sjogrens Syndrome

What are the clinical manifestations of primary Sjogrens Syndrome?

Manifestations can be divided into sicca symptoms and extraglandular features, which are seen in 75% of patients and may precede the development of KCS.

Clinical Manifestations of Primary Sjogren’s Syndrome

Sicca SymptomsPrevalence (%)
Xerophthalmia90–95
Xerostomia90–95
Dyspareunia40–60
Parotid gland enlargement40–60
Extraglandular features
Fatigue60–70
Arthralgias/arthritis45–60
Raynaud’s phenomenon13–33
Esophageal dysfunction30–35
Autoimmune thyroid disease14–33
Lymphadenopathy15–20
Lung involvement10–20
Kidney involvement5–10
Liver involvement5–10
Cutaneous vasculitis5–10
Lymphoma5–10
Peripheral neuropathy2–5
Central nervous system disease1–2
Myositis1–2
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