Autonomic abnormalities in primary Sjogrens Syndrome

Autonomic abnormalities in primary Sjogrens Syndrome

What are the autonomic abnormalities seen in primary Sjogrens Syndrome? 

This chronic autoimmune disorder, which affects women nine times as frequently as men, is characterized by highly specific autoantibodies, Ro (SS-A) and La (SS-B), directed against low-molecular-weight ribonuclear proteins.

Signs of all forms of peripheral neuropathy (sensory neuropathy, sensorimotor neuropathy, multiple mononeuropathies, sensory neuronopathy, cranial neuropathy, and entrapment syndromes) may be seen in 5% to 20% of patients with Sjögren’s syndrome.

Autonomic dysfunction, including Adie’s pupil, anhidrosis, urinary retention, orthostatic hypotension, and impaired cardiac parasympathetic function, may be superimposed on a generalized neuropathy.

It is hypothesized that antibodies to M3-receptors and antibodies to nicotinic ganglionic acetylcholine receptors may play a role in some autonomic manifestations in primary Sjögren’s syndrome.

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