How is celiac disease diagnosed
The gold standard is jejunal biopsy showing villous atrophy.
However, autoantibody testing is very helpful in screening individuals prior to biopsy.
On a gluten-rich diet in people who are not IgA-deficient, IgA antibodies against tissue transglutaminase have a high sensitivity (95%) and specificity (90%) for celiac disease. Due to poor specificity, antigliadin antibodies are no longer used to screen for celiac disease.