How is celiac disease diagnosed

How is celiac disease diagnosed

The gold standard is jejunal biopsy showing villous atrophy.

However, autoantibody testing is very helpful in screening individuals prior to biopsy.

On a gluten-rich diet in people who are not IgA-deficient, IgA antibodies against tissue transglutaminase have a high sensitivity (95%) and specificity (90%) for celiac disease. Due to poor specificity, antigliadin antibodies are no longer used to screen for celiac disease.

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