Rheumatic manifestations in celiac disease

Rheumatic manifestations in celiac disease

What rheumatic manifestations have been described in patients with celiac disease (gluten sensitive enteropathy)?

• Arthritis (∼25%)—symmetric, nonerosive polyarthritis involving predominantly large joints (knees and ankles > hips and shoulders). May precede enteropathic symptoms in 50% of cases. Notably an oligoarthritis and sacroiliitis have also been reported. The arthritis responds to a gluten-free diet in 40% to 60% of cases.

• Metabolic bone disease occurs in most and can be complicated by secondary hyperparathyroidism and even osteomalacia due to steatorrhea from severe enteropathy causing vitamin D deficiency. Some of these patients are mistakenly diagnosed as fibromyalgia with irritable bowel syndrome.

• Dermatitis herpetiformis is present in 15%–25% of individuals with celiac disease and usually responds to a gluten-free diet. Dapsone can also be used.


Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

Scroll to Top