Zileuton

What is Zileuton

Zileuton is an oral leukotriene modifier, specifically an inhibitor of leukotriene synthesis.

Zileuton inhibits the first enzyme in the lipoxygenase pathway, 5-lipoxygenase, and thereby limits the formation of potent leukotrienes (LTB4, LTC4, LTD4, and LTE4) which are implicated in the complicated inflammatory response that occurs in certain disease states.

Zileuton is indicated for the prophylaxis and chronic maintenance treatment of asthma in adult and pediatric patients 12 years of age and older.

Brand Name

  • Zyflo
  • Zyflo CR

Indications & Dosage

  • aspirin-induced asthma
  • asthma
  • exercise-induced bronchospasm prophylaxis

For the prophylaxis and chronic maintenance treatment of asthma

Side Effects

  1. abdominal pain
  2. agitation
  3. anxiety
  4. arthralgia
  5. asthenia
  6. chest pain (unspecified)
  7. chills
  8. conjunctivitis
  9. constipation
  10. depression
  11. diarrhea
  12. dizziness
  13. drowsiness
  14. dyspepsia
  15. elevated hepatic enzymes
  16. fatigue
  17. fever
  18. flatulence
  19. hallucinations
  20. headache
  21. hepatitis
  22. hyperbilirubinemia
  23. hypertonia
  24. infection
  25. insomnia
  26. irritability
  27. jaundice
  28. leukopenia
  29. lymphadenopathy
  30. malaise
  31. myalgia
  32. nausea
  33. paresthesias
  34. pruritus
  35. rash
  36. restlessness
  37. seizures
  38. sinusitis
  39. suicidal ideation
  40. tremor
  41. vaginitis
  42. vomiting

Monitoring Parameters

  • LFTs

Contraindications

  • acute bronchospasm
  • alcoholism
  • behavioral changes
  • breast-feeding
  • children
  • geriatric
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • infants
  • jaundice
  • neonates
  • pregnancy
  • psychiatric event
  • status asthmaticus
  • suicidal ideation

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Alfentanil
  • Alosetron
  • Alprazolam
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Anagrelide
  • Aprepitant, Fosaprepitant
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Atazanavir
  • Atazanavir; Cobicistat
  • Azelastine; Fluticasone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bendamustine
  • Bepridil
  • Betamethasone
  • Boceprevir
  • Bosentan
  • Bromocriptine
  • Budesonide
  • Budesonide; Formoterol
  • Bupivacaine; Lidocaine
  • Buspirone
  • Caffeine
  • Caffeine; Ergotamine
  • Carbamazepine
  • Ceritinib
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Ciclesonide
  • Cinacalcet
  • Ciprofloxacin
  • Cisapride
  • Clarithromycin
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Crizotinib
  • Cyclosporine
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Dexamethasone
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dihydroergotamine
  • Diltiazem
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Doxercalciferol
  • Dronedarone
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Elbasvir; Grazoprevir
  • Eltrombopag
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enalapril; Felodipine
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Estazolam
  • Ezetimibe; Simvastatin
  • Felodipine
  • Fludrocortisone
  • Flunisolide
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Formoterol; Mometasone
  • Fosamprenavir
  • Green Tea
  • Halofantrine
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocortisone
  • Idelalisib
  • Indinavir
  • Isavuconazonium
  • Isradipine
  • Levomethadyl
  • Lidocaine
  • Lomitapide
  • Lopinavir; Ritonavir
  • Lovastatin
  • Lovastatin; Niacin
  • Mefloquine
  • Melatonin
  • Methylergonovine
  • Methylprednisolone
  • Methysergide
  • Mexiletine
  • Midazolam
  • Mitotane
  • Mometasone
  • Nelfinavir
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Obeticholic Acid
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Oxybutynin
  • Paricalcitol
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pimozide
  • Pirfenidone
  • Pomalidomide
  • Posaconazole
  • Prednisolone
  • Prednisone
  • Propafenone
  • Propranolol
  • Protease inhibitors
  • Quazepam
  • Quinidine
  • Ramelteon
  • Rasagiline
  • Riluzole
  • Ritonavir
  • Rofecoxib
  • Ropinirole
  • Ropivacaine
  • Saquinavir
  • Sildenafil
  • Silodosin
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sirolimus
  • St. John’s Wort, Hypericum perforatum
  • Tacrine
  • Tacrolimus
  • Tadalafil
  • Tamsulosin
  • Tasimelteon
  • Telaprevir
  • Telotristat Ethyl
  • Terbinafine
  • Terfenadine
  • Theophylline, Aminophylline
  • Thiabendazole
  • Tipranavir
  • Tizanidine
  • Trandolapril; Verapamil
  • Triamcinolone
  • Triazolam
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Warfarin
  • Zonisamide
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