Zafirlukast

What is Zafirlukast

Zafirlukast is an oral leukotriene receptor antagonist for the treatment of asthma. Leukotriene receptor antagonists primarily help to control the inflammatory process of asthma, thus helping to prevent asthma symptoms.

Zafirlukast has been effective in controlling persistent asthma symptoms in adults and children >= 5 years of age as monotherapy or in combination with inhaled corticosteroids or beta-agonists.

Consistent improvements in lung function (i.e., FEV1) and decreased use of inhaled beta-2 agonists for rescue therapy are seen with the use of zafirlukast in the treatment of mild-to-moderate asthma.

Leukotriene antagonists are considered an alternate, but not preferred, treatment to the use of inhaled corticosteroids (ICSs) for mild persistent asthma (step 2 care) according to the 2007 guidelines of the Expert Panel of the National Asthma Education and Prevention Program.

Brand Name

Accolate

Indications & Dosage

  • allergic rhinitis
  • asthma
  • exercise-induced bronchospasm prophylaxis

For the chronic treatment and prevention of the symptoms of asthma, either as monotherapy or as add-on therapy in patients whose persistent mild-moderate asthma is inadequately controlled with inhaled corticosteroids.

Side Effects

  1. abdominal pain
  2. agitation
  3. agranulocytosis
  4. angioedema
  5. anxiety
  6. arthralgia
  7. asthenia
  8. back pain
  9. chest pain (unspecified)
  10. Churg-Strauss syndrome
  11. clastogenesis
  12. depression
  13. diarrhea
  14. dizziness
  15. dyspepsia
  16. dyspnea
  17. ecchymosis
  18. elevated hepatic enzymes
  19. eosinophilia
  20. eosinophilic pneumonia
  21. fatigue
  22. fever
  23. hallucinations
  24. headache
  25. hepatic failure
  26. hepatitis
  27. hyperbilirubinemia
  28. infection
  29. insomnia
  30. irritability
  31. jaundice
  32. lethargy
  33. malaise
  34. myalgia
  35. nausea
  36. peripheral neuropathy
  37. pharyngitis
  38. pruritus
  39. rash
  40. restlessness
  41. seizures
  42. sinusitis
  43. suicidal ideation
  44. tremor
  45. urticaria
  46. vasculitis
  47. vesicular rash
  48. vomiting
  49. weakness

Monitoring Parameters

  • LFTs

Contraindications

  • acute bronchospasm
  • breast-feeding
  • children
  • corticosteroid withdrawal
  • depression
  • females
  • geriatric
  • hepatic disease
  • hepatic encephalopathy
  • hepatitis
  • infants
  • jaundice
  • neonates
  • pregnancy
  • status asthmaticus
  • suicidal ideation
  • vasculitis

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alprazolam
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Artemether; Lumefantrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Avanafil
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzhydrocodone; Acetaminophen
  • Bepridil
  • Boceprevir
  • Bosentan
  • Bromocriptine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Bupivacaine; Lidocaine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Caffeine; Ergotamine
  • Cannabidiol
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Celecoxib
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cilostazol
  • Cinacalcet
  • Cisapride
  • Clarithromycin
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cobimetinib
  • Conivaptan
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Corticosteroids
  • Cyclosporine
  • Dapagliflozin; Saxagliptin
  • Darifenacin
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diclofenac
  • Diclofenac; Misoprostol
  • Dienogest; Estradiol valerate
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Disopyramide
  • Dofetilide
  • Dolutegravir; Rilpivirine
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Drospirenone; Estradiol
  • Dutasteride; Tamsulosin
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Eltrombopag
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Felodipine
  • Ergonovine
  • Ergotamine
  • Erlotinib
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estropipate
  • Eszopiclone
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Felodipine
  • Fentanyl
  • Fesoterodine
  • Flibanserin
  • Flurazepam
  • Fluvastatin
  • food
  • Fosphenytoin
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halofantrine
  • Haloperidol
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Isavuconazonium
  • Isradipine
  • Ivabradine
  • Ixabepilone
  • Lemborexant
  • Lesinurad
  • Lesinurad; Allopurinol
  • Levomethadyl
  • Lidocaine
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Losartan
  • Lovastatin
  • Lovastatin; Niacin
  • Lumacaftor; Ivacaftor
  • Lurasidone
  • Maraviroc
  • Mefloquine
  • Meloxicam
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Methadone
  • Methylergonovine
  • Methysergide
  • Midazolam
  • Nateglinide
  • Nebivolol; Valsartan
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nisoldipine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oritavancin
  • Oxybutynin
  • Oxycodone
  • Paclitaxel
  • Paricalcitol
  • Pazopanib
  • Perindopril; Amlodipine
  • Phenytoin
  • Pimozide
  • Pioglitazone
  • Pirfenidone
  • Piroxicam
  • Propafenone
  • Quazepam
  • Quetiapine
  • Quinidine
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Repaglinide
  • Rilpivirine
  • Riluzole
  • Riociguat
  • Ritonavir
  • Rivaroxaban
  • Rofecoxib
  • Romidepsin
  • Rosiglitazone
  • Ruxolitinib
  • Sacubitril; Valsartan
  • Saquinavir
  • Saxagliptin
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Suvorexant
  • Tadalafil
  • Tamsulosin
  • Telaprevir
  • Telithromycin
  • Terbinafine
  • Theophylline, Aminophylline
  • Tolbutamide
  • Tolterodine
  • Trandolapril; Verapamil
  • Triazolam
  • Ubrogepant
  • Ulipristal
  • Valdecoxib
  • Valsartan
  • Vemurafenib
  • Verapamil
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Vorapaxar
  • Voriconazole
  • Warfarin
  • Zonisamide
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