Vinorelbine Brand Name
Navelbine
What is Vinorelbine
Vinorelbine is a semi-synthetic vinca alkaloid derived from the Catharanthus roseus or Madagascar periwinkle plant.
It acts as a microtubule inhibitor, causing cellular instability and preventing mitosis at metaphase.
Microtubules are responsible for intracellular transport, maintenance of cell shape, polarity, cell signaling, and mitosis. During mitosis, microtubules form the mitotic spindle that transports daughter chromosomes to separate poles of the dividing cell.
Vinorelbine is more potent and less neurotoxic than vinblastine and vincristine.
Vinorelbine is indicated for the treatment of non-small cell lung cancer (NSCLC) as monotherapy and in combination with cisplatin. The primary dose-limiting toxicity is neutropenia.
Monitor complete blood counts prior to each dose; an adjustment to the dose of vinorelbine may be necessary for neutropenia. Vinorelbine is also a vesicant; monitor closely for signs of extravasation.
Indications
- breast cancer
- desmoid tumor
- head and neck cancer
- Hodgkin lymphoma
- non-small cell lung cancer (NSCLC)
- ovarian cancer
Side Effects
- abdominal pain
- acute respiratory distress syndrome (ARDS)
- alopecia
- alopecia
- anaphylactoid reactions
- anemia
- anemia
- angioedema
- anorexia
- arthralgia
- asthenia
- asthenia
- back pain
- bone marrow suppression
- bronchospasm
- chest pain (unspecified)
- constipation
- constipation
- diarrhea
- diarrhea
- dysgeusia
- dysphagia
- dyspnea
- dyspnea
- elevated hepatic enzymes
- elevated hepatic enzymes
- erythema
- esophagitis
- fatigue
- fever
- flushing
- GI obstruction
- GI perforation
- headache
- hearing loss
- hemorrhagic cystitis
- hyperbilirubinemia
- hyperbilirubinemia
- hyperesthesia
- hypertension
- hyponatremia
- hyporeflexia
- hypotension
- ileus
- infection
- injection site reaction
- injection site reaction
- lethargy
- leukopenia
- leukopenia
- malaise
- myalgia
- myasthenia
- myocardial infarction
- nausea
- nausea
- neurotoxicity
- neurotoxicity
- neutropenia
- neutropenia
- ototoxicity
- palmar-plantar erythrodysesthesia (hand and foot syndrome)
- pancreatitis
- paresthesias
- peripheral neuropathy
- peripheral neuropathy
- peripheral vasodilation
- phlebitis
- phlebitis
- pneumonitis
- pruritus
- pulmonary edema
- pulmonary embolism
- pulmonary toxicity
- radiation recall reaction
- rash
- SIADH
- sinus tachycardia
- thrombocytopenia
- thrombocytopenia
- thrombosis
- tissue necrosis
- urticaria
- vomiting
- vomiting
- weakness
- weakness
- weight loss
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
Contraindications
- anemia
- autonomic neuropathy
- bone marrow suppression
- breast-feeding
- children
- constipation
- contraception requirements
- extravasation
- GI obstruction
- GI perforation
- hepatic disease
- ileus
- infants
- infection
- infertility
- intrathecal administration
- male-mediated teratogenicity
- neurotoxicity
- neutropenia
- ocular exposure
- peripheral neuropathy
- pneumonitis
- pregnancy
- pregnancy testing
- pulmonary disease
- pulmonary toxicity
- reproductive risk
- thrombocytopenia
Interactions
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alpha interferons
- Amiodarone
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Atazanavir
- Atazanavir; Cobicistat
- Betrixaban
- Bicalutamide
- Bivalirudin
- Ceritinib
- Chloramphenicol
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabigatran
- Dalfopristin; Quinupristin
- Dalteparin
- Danaparoid
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Desirudin
- Diltiazem
- Dronedarone
- Duvelisib
- Echinacea
- Edoxaban
- Elbasvir; Grazoprevir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enoxaparin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Everolimus
- Febuxostat
- Fedratinib
- Filgrastim, G-CSF
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Fondaparinux
- Fosamprenavir
- Fostamatinib
- Gadobenate Dimeglumine
- Ganciclovir
- grapefruit juice
- Heparin
- Idelalisib
- Imatinib
- Indinavir
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Istradefylline
- Itraconazole
- Ketoconazole
- Lapatinib
- Larotrectinib
- Lefamulin
- Lepirudin
- Letermovir
- Live Vaccines
- Lopinavir; Ritonavir
- Mifepristone
- Mitomycin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nicardipine
- Nilotinib
- Ombitasvir; Paritaprevir; Ritonavir
- Palbociclib
- Palifermin
- Pazopanib
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentosan
- Perindopril; Amlodipine
- Posaconazole
- Quinine
- Ranolazine
- Ribociclib
- Ribociclib; Letrozole
- Ritonavir
- Rivaroxaban
- Rucaparib
- Saquinavir
- Selpercatinib
- Simeprevir
- Streptogramins
- Tbo-Filgrastim
- Telithromycin
- Ticagrelor
- Tinzaparin
- Tipranavir
- Trandolapril; Verapamil
- Tuberculin Purified Protein Derivative, PPD
- Tucatinib
- Valganciclovir
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
