Vincristine Liposomal

Vincristine Liposomal Brand Name

Marqibo

What is Vincristine Liposomal

Liposomal vincristine is a sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine sulfate, a vinca alkaloid agent.

It is indicated for the treatment of adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies.

Neurologic toxicity (e.g., peripheral neuropathy and paralytic ileus) and myelosuppression have been reported with liposomal vincristine therapy.

Indications

  • acute lymphocytic leukemia (ALL)

For the treatment of Philadelphia chromosome-negative acute lymphocytic leukemia (ALL) in second or greater relapse or that has progressed after 2 or more anti-leukemia therapies

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. arthralgia
  5. asthenia
  6. cardiac arrest
  7. constipation
  8. diarrhea
  9. elevated hepatic enzymes
  10. erythema
  11. fatigue
  12. fever
  13. hepatic failure
  14. hyperbilirubinemia
  15. hyperesthesia
  16. hyperkalemia
  17. hyperphosphatemia
  18. hyperuricemia
  19. hypocalcemia
  20. hypoesthesia
  21. hyporeflexia
  22. hypotension
  23. ileus
  24. infection
  25. injection site reaction
  26. insomnia
  27. musculoskeletal pain
  28. myalgia
  29. nausea
  30. neutropenia
  31. paresthesias
  32. peripheral neuropathy
  33. phlebitis
  34. respiratory arrest
  35. skin irritation
  36. thrombocytopenia
  37. tissue necrosis
  38. tumor lysis syndrome (TLS)
  39. weakness

Monitoring Parameters

  • CBC with differential
  • LFTs
  • neurologic function
  • pregnancy testing
  • serum creatinine
  • serum electrolytes
  • serum uric acid

Contraindications

  • anemia
  • breast-feeding
  • constipation
  • contraception requirements
  • ensure correct formulation selection
  • GI obstruction
  • hepatic disease
  • ileus
  • infertility
  • intrathecal administration
  • male-mediated teratogenicity
  • neurological disease
  • neutropenia
  • peripheral neuropathy
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thrombocytopenia
  • tumor lysis syndrome (TLS)

Vincristine liposomal is contraindicated for use by patients with hypersensitivity to vincristine sulfate or any of the other product components.

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Alpha interferons
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amiodarone
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amprenavir
  • Antacids
  • Anticoagulants
  • Antithrombin III
  • Apalutamide
  • Apixaban
  • Aprepitant, Fosaprepitant
  • Argatroban
  • Armodafinil
  • Asparaginase Erwinia chrysanthemi
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Betamethasone
  • Betrixaban
  • Bexarotene
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Boceprevir
  • Bortezomib
  • Bosutinib
  • Brigatinib
  • Budesonide
  • Budesonide; Formoterol
  • Butabarbital
  • Cabozantinib
  • Caffeine
  • Calcium Carbonate; Magnesium Hydroxide
  • Capmatinib
  • Carbamazepine
  • Carvedilol
  • Ceritinib
  • Chloramphenicol
  • Choline Salicylate; Magnesium Salicylate
  • Ciclesonide
  • Cimetidine
  • Clarithromycin
  • Clozapine
  • Cobicistat
  • Colchicine
  • Colchicine; Probenecid
  • Conivaptan
  • Corticosteroids
  • Corticotropin, ACTH
  • Cortisone
  • Crizotinib
  • Cyclosporine
  • Dabigatran
  • Dabrafenib
  • Dalteparin
  • Danaparoid
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Desirudin
  • Desmopressin
  • Dexamethasone
  • Dextromethorphan; Quinidine
  • Diazoxide
  • Dichlorphenamide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Dronedarone
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Echinacea
  • Edoxaban
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enoxaparin
  • Enzalutamide
  • Erdafitinib
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Esomeprazole; Naproxen
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etodolac
  • Etravirine
  • Famotidine; Ibuprofen
  • Febuxostat
  • Felbamate
  • Fenoprofen
  • Filgrastim, G-CSF
  • Fludrocortisone
  • Flunisolide
  • Flurbiprofen
  • Flutamide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fondaparinux
  • Formoterol; Mometasone
  • Fosamprenavir
  • Fosphenytoin
  • Gadobenate Dimeglumine
  • Ganciclovir
  • Glecaprevir; Pibrentasvir
  • grapefruit juice
  • Heparin
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Idelalisib
  • Imatinib
  • Indinavir
  • Indomethacin
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Isavuconazonium
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Istradefylline
  • Itraconazole
  • Ixabepilone
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • L-Asparaginase Escherichia coli
  • Lansoprazole; Naproxen
  • Lapatinib
  • Ledipasvir; Sofosbuvir
  • Lepirudin
  • Letermovir
  • Live Vaccines
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Magnesium Hydroxide
  • Magnesium Salicylate
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Mephobarbital
  • Methadone
  • Methohexital
  • Methotrexate
  • Methyldopa
  • Methylprednisolone
  • Mifepristone
  • Mitomycin
  • Mitotane
  • Modafinil
  • Mometasone
  • Nabumetone
  • Nafcillin
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nelfinavir
  • Neratinib
  • Netupitant, Fosnetupitant; Palonosetron
  • Nifedipine
  • Nilotinib
  • Octreotide
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Oritavancin
  • Osimertinib
  • Oxaprozin
  • Oxcarbazepine
  • Palifermin
  • Pazopanib
  • Pegaspargase
  • Pegfilgrastim
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Penicillamine
  • Pentobarbital
  • Pentosan
  • Perampanel
  • Phenobarbital
  • Phenytoin
  • Piroxicam
  • Posaconazole
  • Prednisolone
  • Prednisone
  • Primidone
  • Propafenone
  • Protease inhibitors
  • Quinidine
  • Quinine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Rifaximin
  • Ritonavir
  • Rivaroxaban
  • Rolapitant
  • Salsalate
  • Saquinavir
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Simeprevir
  • Sorafenib
  • St. John’s Wort, Hypericum perforatum
  • Sulindac
  • Tbo-Filgrastim
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temsirolimus
  • Teniposide
  • Testosterone
  • Thalidomide
  • Thiopental
  • Ticagrelor
  • Tinzaparin
  • Tipranavir
  • Tolmetin
  • Trandolapril; Verapamil
  • Triamcinolone
  • Trientine
  • Trifluoperazine
  • Tuberculin Purified Protein Derivative, PPD
  • Tucatinib
  • Valganciclovir
  • Valproic Acid, Divalproex Sodium
  • Vasopressin, ADH
  • Vemurafenib
  • Verapamil
  • Voriconazole
  • Warfarin
  • Zafirlukast
  • Zalcitabine, ddC
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