Vincristine Liposomal Brand Name
Marqibo
What is Vincristine Liposomal
Liposomal vincristine is a sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine sulfate, a vinca alkaloid agent.
It is indicated for the treatment of adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies.
Neurologic toxicity (e.g., peripheral neuropathy and paralytic ileus) and myelosuppression have been reported with liposomal vincristine therapy.
Indications
- acute lymphocytic leukemia (ALL)
For the treatment of Philadelphia chromosome-negative acute lymphocytic leukemia (ALL) in second or greater relapse or that has progressed after 2 or more anti-leukemia therapies
Side Effects
- abdominal pain
- anemia
- anorexia
- arthralgia
- asthenia
- cardiac arrest
- constipation
- diarrhea
- elevated hepatic enzymes
- erythema
- fatigue
- fever
- hepatic failure
- hyperbilirubinemia
- hyperesthesia
- hyperkalemia
- hyperphosphatemia
- hyperuricemia
- hypocalcemia
- hypoesthesia
- hyporeflexia
- hypotension
- ileus
- infection
- injection site reaction
- insomnia
- musculoskeletal pain
- myalgia
- nausea
- neutropenia
- paresthesias
- peripheral neuropathy
- phlebitis
- respiratory arrest
- skin irritation
- thrombocytopenia
- tissue necrosis
- tumor lysis syndrome (TLS)
- weakness
Monitoring Parameters
- CBC with differential
- LFTs
- neurologic function
- pregnancy testing
- serum creatinine
- serum electrolytes
- serum uric acid
Contraindications
- anemia
- breast-feeding
- constipation
- contraception requirements
- ensure correct formulation selection
- GI obstruction
- hepatic disease
- ileus
- infertility
- intrathecal administration
- male-mediated teratogenicity
- neurological disease
- neutropenia
- peripheral neuropathy
- pregnancy
- pregnancy testing
- reproductive risk
- thrombocytopenia
- tumor lysis syndrome (TLS)
Vincristine liposomal is contraindicated for use by patients with hypersensitivity to vincristine sulfate or any of the other product components.
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Alpha interferons
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Antacids
- Anticoagulants
- Antithrombin III
- Apalutamide
- Apixaban
- Aprepitant, Fosaprepitant
- Argatroban
- Armodafinil
- Asparaginase Erwinia chrysanthemi
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Betrixaban
- Bexarotene
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bivalirudin
- Boceprevir
- Bortezomib
- Bosutinib
- Brigatinib
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Cabozantinib
- Caffeine
- Calcium Carbonate; Magnesium Hydroxide
- Capmatinib
- Carbamazepine
- Carvedilol
- Ceritinib
- Chloramphenicol
- Choline Salicylate; Magnesium Salicylate
- Ciclesonide
- Cimetidine
- Clarithromycin
- Clozapine
- Cobicistat
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Corticosteroids
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- Cortisone
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- Cyclosporine
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- Dabrafenib
- Dalteparin
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- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deflazacort
- Delavirdine
- Desirudin
- Desmopressin
- Dexamethasone
- Dextromethorphan; Quinidine
- Diazoxide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Echinacea
- Edoxaban
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enoxaparin
- Enzalutamide
- Erdafitinib
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esomeprazole; Naproxen
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etodolac
- Etravirine
- Famotidine; Ibuprofen
- Febuxostat
- Felbamate
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Flutamide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Gadobenate Dimeglumine
- Ganciclovir
- Glecaprevir; Pibrentasvir
- grapefruit juice
- Heparin
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Imatinib
- Indinavir
- Indomethacin
- Interferon Alfa-2a
- Interferon Alfa-2b
- Interferon Alfa-2b; Ribavirin
- Interferon Alfa-n3
- Interferon Alfacon-1
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Istradefylline
- Itraconazole
- Ixabepilone
- Ketoconazole
- Ketoprofen
- Ketorolac
- L-Asparaginase Escherichia coli
- Lansoprazole; Naproxen
- Lapatinib
- Ledipasvir; Sofosbuvir
- Lepirudin
- Letermovir
- Live Vaccines
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Magnesium Salicylate
- Meclofenamate Sodium
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- Meloxicam
- Mephobarbital
- Methadone
- Methohexital
- Methotrexate
- Methyldopa
- Methylprednisolone
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- Mitomycin
- Mitotane
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- Nabumetone
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nelfinavir
- Neratinib
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- Nilotinib
- Octreotide
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osimertinib
- Oxaprozin
- Oxcarbazepine
- Palifermin
- Pazopanib
- Pegaspargase
- Pegfilgrastim
- Peginterferon Alfa-2a
- Peginterferon Alfa-2b
- Penicillamine
- Pentobarbital
- Pentosan
- Perampanel
- Phenobarbital
- Phenytoin
- Piroxicam
- Posaconazole
- Prednisolone
- Prednisone
- Primidone
- Propafenone
- Protease inhibitors
- Quinidine
- Quinine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Rivaroxaban
- Rolapitant
- Salsalate
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Simeprevir
- Sorafenib
- St. John’s Wort, Hypericum perforatum
- Sulindac
- Tbo-Filgrastim
- Telaprevir
- Telithromycin
- Telotristat Ethyl
- Temsirolimus
- Teniposide
- Testosterone
- Thalidomide
- Thiopental
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- Tinzaparin
- Tipranavir
- Tolmetin
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- Triamcinolone
- Trientine
- Trifluoperazine
- Tuberculin Purified Protein Derivative, PPD
- Tucatinib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Vasopressin, ADH
- Vemurafenib
- Verapamil
- Voriconazole
- Warfarin
- Zafirlukast
- Zalcitabine, ddC
