Vismodegib

Vismodegib Brand Name – Erivedge

What is Vismodegib

Vismodegib is an oral hedgehog pathway inhibitor. It is indicated for the treatment of adults with metastatic basal cell carcinoma (BCC) or in patients with locally advanced BCC that has recurred following surgery.

Vismodegib is also indicated for patients with locally advanced BCC who are not candidates for surgery or radiation therapy.

Vismodegib may cause embryo-fetal death or severe birth defects when administered during pregnancy.

Indications

  • basal cell carcinoma

For the treatment of basal cell carcinoma (BCC)

for the treatment of metastatic BCC or locally advanced BCC that has recurred following surgery or in patients who are not candidates for surgery or radiation

Side Effects

  1. alopecia
  2. amenorrhea
  3. anorexia
  4. anorexia
  5. arthralgia
  6. arthralgia
  7. azotemia
  8. constipation
  9. diarrhea
  10. diarrhea
  11. dysgeusia
  12. fatigue
  13. fatigue
  14. fetal death
  15. growth inhibition
  16. hepatotoxicity
  17. hypokalemia
  18. hyponatremia
  19. muscle cramps
  20. muscle cramps
  21. nausea
  22. nausea
  23. new primary malignancy
  24. teratogenesis
  25. vomiting
  26. weight loss
  27. weight loss

Monitoring Parameters

  • pregnancy testing

Contraindications

  • blood donation
  • breast-feeding
  • children
  • contraception requirements
  • growth inhibition
  • infants
  • infertility
  • intrauterine fetal death
  • male-mediated teratogenicity
  • neonates
  • precocious puberty
  • pregnancy
  • pregnancy testing
  • reproductive risk

Interactions

  • Clozapine
  • grapefruit juice
  • Warfarin
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